Abscopal effect with fever of unknown cause during radiotherapy: Two case reports and review of the literature

  • Authors:
    • Yoshiko Oshiro
    • Masashi Mizumoto
    • Takayuki Hisanaga
    • Ken Tanaka
    • Manabu Komine
    • Mizuki Takahashi
    • Koji Kikuchi
    • Hideyuki Sakurai
  • View Affiliations

  • Published online on: September 18, 2023     https://doi.org/10.3892/etm.2023.12209
  • Article Number: 510
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Abstract

The abscopal effect is a rare phenomenon that is defined as regression of tumor lesions distant from irradiation targets. At our department, two cases with an abscopal effect with fever of unknown cause (FUC) and an inflammatory response during radiotherapy were encountered. Radiotherapy is a local treatment; therefore, it rarely causes systemic side effects during radiotherapy, and if a patient develops a fever during radiotherapy, it is frequently considered tumor fever. We experienced 2 cases of FUC during irradiation followed by abscopal effect. The obvious relationship between the abscopal effect and the fever remains to be clarified. However, FUC during radiotherapy may be a hint to the abscopal effect, considering that immune response and cytokines are closely related to the abscopal effect.
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November-2023
Volume 26 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Oshiro Y, Mizumoto M, Hisanaga T, Tanaka K, Komine M, Takahashi M, Kikuchi K and Sakurai H: Abscopal effect with fever of unknown cause during radiotherapy: Two case reports and review of the literature. Exp Ther Med 26: 510, 2023.
APA
Oshiro, Y., Mizumoto, M., Hisanaga, T., Tanaka, K., Komine, M., Takahashi, M. ... Sakurai, H. (2023). Abscopal effect with fever of unknown cause during radiotherapy: Two case reports and review of the literature. Experimental and Therapeutic Medicine, 26, 510. https://doi.org/10.3892/etm.2023.12209
MLA
Oshiro, Y., Mizumoto, M., Hisanaga, T., Tanaka, K., Komine, M., Takahashi, M., Kikuchi, K., Sakurai, H."Abscopal effect with fever of unknown cause during radiotherapy: Two case reports and review of the literature". Experimental and Therapeutic Medicine 26.5 (2023): 510.
Chicago
Oshiro, Y., Mizumoto, M., Hisanaga, T., Tanaka, K., Komine, M., Takahashi, M., Kikuchi, K., Sakurai, H."Abscopal effect with fever of unknown cause during radiotherapy: Two case reports and review of the literature". Experimental and Therapeutic Medicine 26, no. 5 (2023): 510. https://doi.org/10.3892/etm.2023.12209