Relationship between MTHFR gene polymorphism and risk of thrombosis in postoperative patients with colorectal cancer

  • Authors:
    • Wei Zhang
    • Li Chen
    • Gaoyang Cao
    • Fei Wang
    • Engeng Chen
  • View Affiliations

  • Published online on: November 3, 2023     https://doi.org/10.3892/etm.2023.12287
  • Article Number: 588
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Abstract

An association between the methylenetetrahydrofolate reductase (MTHFR) C667T genotype and the risk of colorectal cancer, as well as a link between MTHFR gene polymorphism and thrombosis, have been revealed. However, the connection between MTHFR gene polymorphism and the risk of thrombosis in patients with colorectal cancer has remained to be fully elucidated. The present study investigated the link between MTHFR gene polymorphism and basic clinical data, postoperative D‑dimer (DDi), postoperative thromboelastogram and postoperative thrombosis in 591 patients who underwent surgery for colorectal cancer. Postoperative DDi, thromboelastogram and postoperative thrombosis were not significantly different among patients with colorectal cancer and different MTHFR genotypes. While the results were ‘negative’, the present study may help physicians understand that it is not necessary to detect MTHFR polymorphism for therapeutic purposes. Regarding the danger of venous thrombosis, more focus should be placed on the standardized procedural enforcement system for deep vein thrombosis prevention for patients undergoing pelvic and abdominal surgery.
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December-2023
Volume 26 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhang W, Chen L, Cao G, Wang F and Chen E: Relationship between MTHFR gene polymorphism and risk of thrombosis in postoperative patients with colorectal cancer. Exp Ther Med 26: 588, 2023.
APA
Zhang, W., Chen, L., Cao, G., Wang, F., & Chen, E. (2023). Relationship between MTHFR gene polymorphism and risk of thrombosis in postoperative patients with colorectal cancer. Experimental and Therapeutic Medicine, 26, 588. https://doi.org/10.3892/etm.2023.12287
MLA
Zhang, W., Chen, L., Cao, G., Wang, F., Chen, E."Relationship between MTHFR gene polymorphism and risk of thrombosis in postoperative patients with colorectal cancer". Experimental and Therapeutic Medicine 26.6 (2023): 588.
Chicago
Zhang, W., Chen, L., Cao, G., Wang, F., Chen, E."Relationship between MTHFR gene polymorphism and risk of thrombosis in postoperative patients with colorectal cancer". Experimental and Therapeutic Medicine 26, no. 6 (2023): 588. https://doi.org/10.3892/etm.2023.12287