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Evaluation of genetic polymorphisms in TNF‑α‑308G/A rs1800629 associated with susceptibility and severity of rheumatoid arthritis: A systematic review and meta‑analysis

  • Authors:
    • Yun-Lu Wang
    • Xi-Yong Li
    • Lun Liu
    • Song-Feng Li
    • Peng-Fei Han
    • Xiao-Dong Li
  • View Affiliations

  • Published online on: May 13, 2024     https://doi.org/10.3892/etm.2024.12567
  • Article Number: 279
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

To investigate the association of gene polymorphisms of TNF‑α‑308G/A rs1800629 with the susceptibility and severity of rheumatoid arthritis (RA), literature from PubMed, EMBASE, Web of Science and CNKI databases was searched. Two authors screened the literature independently, extracted data and evaluated the risk of bias of the included studies. According to the inclusion and exclusion criteria, five genetic models were established: The allelic model (A vs. G), dominant model (GA + AA vs. GG), recessive model (AA vs. GG + GA), co‑dominant model (AA vs. GG) and super‑dominant model (GG + AA vs. GA). Stata 17.0 software was used for the meta‑analysis. A total of 34 eligible studies with 12,611 subjects were included, including 6,030 cases in the RA group and 6,581 controls. Meta‑analysis calculations revealed that the genetic polymorphisms of TNF‑α‑308G/A rs1800629 were not significantly associated with susceptibility to RA, with an odds ratio and 95% confidence interval (CI) for each genetic model [A vs. G: 0.937 (0.762‑1.152); GA + AA vs. GG: 0.918 (0.733‑1.148); AA vs. GG + GA: 1.131 (0.709‑1.802); AA vs. GG: 1.097 (0.664‑1.813); and GG + AA vs. GA: 1.108 (0.894‑1.373)]. For the association between TNF‑α‑308G/A rs1800629 gene polymorphisms and the severity of RA, the results of subgroup analysis calculations showed that TNF‑α‑308G/A rs1800629 gene polymorphisms were associated with the severity of RA in European populations, with the gene model and 95% CI [GA + AA vs. GG: 0.503 (0.297‑0.853); and GG + AA vs. GA: 2.268 (1.434‑3.590)]. When assessing the confidence in the positive results of the present study through the false‑positive report probability, the positive results were observed to be reliable. No significant association was observed between genetic polymorphisms in TNF‑α‑308G/A rs1800629 and susceptibility to RA. However, a significant association exists with the severity of RA in European populations.
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July-2024
Volume 28 Issue 1

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Spandidos Publications style
Wang Y, Li X, Liu L, Li S, Han P and Li X: Evaluation of genetic polymorphisms in TNF‑α‑308G/A rs1800629 associated with susceptibility and severity of rheumatoid arthritis: A systematic review and meta‑analysis. Exp Ther Med 28: 279, 2024
APA
Wang, Y., Li, X., Liu, L., Li, S., Han, P., & Li, X. (2024). Evaluation of genetic polymorphisms in TNF‑α‑308G/A rs1800629 associated with susceptibility and severity of rheumatoid arthritis: A systematic review and meta‑analysis. Experimental and Therapeutic Medicine, 28, 279. https://doi.org/10.3892/etm.2024.12567
MLA
Wang, Y., Li, X., Liu, L., Li, S., Han, P., Li, X."Evaluation of genetic polymorphisms in TNF‑α‑308G/A rs1800629 associated with susceptibility and severity of rheumatoid arthritis: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 28.1 (2024): 279.
Chicago
Wang, Y., Li, X., Liu, L., Li, S., Han, P., Li, X."Evaluation of genetic polymorphisms in TNF‑α‑308G/A rs1800629 associated with susceptibility and severity of rheumatoid arthritis: A systematic review and meta‑analysis". Experimental and Therapeutic Medicine 28, no. 1 (2024): 279. https://doi.org/10.3892/etm.2024.12567