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Print ISSN: 1792-0981 Online ISSN: 1792-1015
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
July-2024 Volume 28 Issue 1

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Impact Factor: 2.3

Article Open Access

Impact of premorbid use of beta‑blockers on survival outcomes of patients with sepsis: A systematic review and meta‑analysis

Huan Chu, Fengmin Fei, Yao Su, Huifei Zhou
Article Number: 300
Published online on: 24 May 2024

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Case Report Open Access

Epileptic seizures as an initial symptom for Sturge‑Weber syndrome type III: A report of two cases

Yaping Wang, Guifu Geng, Wandong Hu, Huan Zhang, Yong Liu, Zaifen Gao, Hongwei Zhang, Jianguo Shi
Article Number: 299
Published online on: 24 May 2024

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Case Report Open Access

Exaggerated placental site in a cesarean scar: Misdiagnosed as gestational trophoblastic neoplasia: A case report

Zongbin Chen, Minghua Wang, Ping Yang, Bo Yao, Hanlin Shuai, Ping Li
Article Number: 298
Published online on: 23 May 2024

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Article Open Access

18‑α‑glycyrrhetinic acid induces apoptosis in gingival fibroblasts exposed to phenytoin

Reiri Takeuchi, Takatoshi Nomura, Manabu Yaguchi, Chieko Taguchi, Itaru Suzuki, Haruka Suzuki, Hiroko Matsumoto, Yuichiro Okada, Kazumune Arikawa, Takato Nomoto, Koichi Hiratsuka
Article Number: 297
Published online on: 22 May 2024

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Case Report Open Access

Groove pancreatitis presenting with upper gastrointestinal obstruction and abnormal renal function: A case report and literature review

Xiaoyuan Fan, Chihong Shi, Dewen Lu
Article Number: 296
Published online on: 22 May 2024

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Article Open Access

Sirtuin 5 alleviates apoptosis and autophagy stimulated by ammonium chloride in bovine mammary epithelial cells

Junhui He, Luping Feng, Hanlin Yang, Shikai Gao, Jinru Dong, Guangyang Lu, Luya Liu, Xinyi Zhang, Kai Zhong, Shuang Guo, Guangming Zha, Liqiang Han, Heping Li, Yueying Wang
Article Number: 295
Published online on: 22 May 2024

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Article Open Access

Detection of PD‑L1 expression and epithelial‑mesenchymal transition of circulating tumor cells in non‑small cell lung cancer

Jianping Jiang, Weiqiang Mo, Xue Lian, Dakui Cao, Haiying Cheng, Haiqin Wang
Article Number: 294
Published online on: 22 May 2024

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Article Open Access

Meteorin‑like/meteorin‑β protects against cardiac dysfunction after myocardial infarction in mice by inhibiting autophagy

Jiahong Shangguan, Gangqiong Liu, Lili Xiao, Wenjing Zhang, Xiaodan Zhu, Ling Li
Article Number: 293
Published online on: 22 May 2024

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Article Open Access

Analysis of gene expression in microglial apoptotic cell clearance following spinal cord injury based on machine learning algorithms

Lei Yan, Chu Chen, Lingling Wang, Hongxiang Hong, Chunshuai Wu, Jiayi Huang, Jiawei Jiang, Jiajia Chen, Guanhua Xu, Zhiming Cui
Article Number: 292
Published online on: 22 May 2024

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Case Report

Role of microsurgical techniques combined with Ilizarov techniques in limb salvage and functional reconstruction of thermal‑crush injuries of the hand: A case report

Jun Yang, Longbiao Yu, Fanbin Meng, Jingjing Wen, Yingfeng Xiao, Shengxiang Wan, Fei Yu, Zhegang Zhou
Article Number: 291
Published online on: 21 May 2024

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Article Open Access

Application of 3D‑printed porous titanium interbody fusion cage vs. polyether ether ketone interbody fusion cage in anterior cervical discectomy and fusion: A systematic review and meta‑analysis update

Wan-Jing Zhai, Lun Liu, Yu-Hao Gao, Shi-Lei Qin, Peng-Fei Han, Yun-Feng Xu
Article Number: 290
Published online on: 21 May 2024

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Article Open Access

Long non‑coding RNAs MALAT1, NEAT1 and DSCR4 can be serum biomarkers in predicting urosepsis occurrence and reflect disease severity

Jianliang Shen, Liangming Pan, Wei Chen, Yechen Wu
Article Number: 289
Published online on: 21 May 2024

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Retraction Open Access

[Retracted] MicroRNA‑379 suppresses cell proliferation, migration and invasion in nasopharyngeal carcinoma by targeting tumor protein D52

Xiaojun Zhao, Jiusheng Chu
Article Number: 288
Published online on: 20 May 2024

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Article Open Access

Effects of extracellular vesicles for ischemic stroke: A meta‑analysis of preclinical studies

Yuan Xie, Tianhao Deng, Le Xie, Yao Xie, Jiaqi Ma, Don Zhong, Xiongying Huang, Yingchen Li
Article Number: 287
Published online on: 16 May 2024

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Article Open Access

Effects of mid‑gestational sevoflurane and magnesium sulfate on maternal oxidative stress, inflammation and fetal brain histopathology

Cagri Ozdemi̇r, Berrin Isik, Gulce Koca, Mehmet Arda Inan
Article Number: 286
Published online on: 16 May 2024

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Article Open Access

Serum miR‑29 is increased in mice with early liver fibrosis

Kana Matsumoto, Yuhei Ohsugi, Chisa Tayama, Momone Hayashi, Yumiko Kato, Mizuho Ohashi, Mitsuru Chiba
Article Number: 285
Published online on: 15 May 2024

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Article Open Access

Effect of previous caesarean section on reproductive and pregnancy outcomes after assisted reproductive technology: A systematic review and meta‑analysis

Dan Cao, Lifen Chen
Article Number: 284
Published online on: 15 May 2024

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Article Open Access

TMF suppresses chondrocyte hypertrophy in osteoarthritic cartilage by mediating the FOXO3a/BMPER pathway

Jishang Huang, Qun Ren, Linhui Jiao, Shuo Niu, Chenghong Liu, Juan Zhou, Longhuo Wu, Yadong Yang
Article Number: 283
Published online on: 15 May 2024

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Case Report Open Access

Coexistence of Parkinson's disease and myasthenia gravis: A case report and literature review

Zhijuan Mao, Qing Nie, Zheng Xue, Zhijun Li
Article Number: 282
Published online on: 13 May 2024

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Article Open Access

Predictive modeling for identifying infection risk following spinal surgery: Optimizing patient management

Ruiyu Wang, Jie Xiao, Qi Gao, Guangxin Xu, Tingting Ni, Jingcheng Zou, Tingting Wang, Ge Luo, Zhenzhen Cheng, Ying Wang, Xinchen Tao, Dawei Sun, Yuanyuan Yao, Min Yan
Article Number: 281
Published online on: 13 May 2024

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Retraction Open Access

[Retracted] MicroRNA‑451a prevents cutaneous squamous cell carcinoma progression via the 3‑phosphoinositide‑dependent protein kinase‑1‑mediated PI3K/AKT signaling pathway

Jixing Fu, Jianhua Zhao, Huamin Zhang, Xiaoli Fan, Wenjun Geng, Shaohua Qiao
Article Number: 280
Published online on: 13 May 2024

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Article Open Access

Evaluation of genetic polymorphisms in TNF‑α‑308G/A rs1800629 associated with susceptibility and severity of rheumatoid arthritis: A systematic review and meta‑analysis

Yun-Lu Wang, Xi-Yong Li, Lun Liu, Song-Feng Li, Peng-Fei Han, Xiao-Dong Li
Article Number: 279
Published online on: 13 May 2024

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Article Open Access

Predictive value of fluorometric method and tandem mass spectrometry for hyperphenylalaninemia and its subtypes in China: A systematic review and meta‑analysis

Zhirong Shang, Pan Xie, Ke Pan, Jialin Liu, Wei Xu, Yue Hu, Li Tang, Qinghua Leng, Shuyu Liu, Chengchuan He
Article Number: 278
Published online on: 10 May 2024

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Article Open Access

Therapeutic potential of vitamin D3 in mitigating high glucose‑induced renal damage: Mechanistic insights into oxidative stress inhibition and TXNIP/NLRP3 signaling pathway blockade

Guanqing Li, Suhuan He, Tao Liu, Na Zheng
Article Number: 277
Published online on: 09 May 2024

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Article Open Access

Purpurogallin carboxylic acid exhibits synergistic effects with 5‑fluorouracil on liver cancer cells in vitro by targeting ABCG2

Pingping Zhao, Wei Liu, Shuqing Wang, Junjie Lun
Article Number: 276
Published online on: 08 May 2024

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Article Open Access

Protective effects of astaxanthin on particulate matter 2.5‑induced senescence in HaCaT keratinocytes via maintenance of redox homeostasis

Ao Xuan Zhen, Kyoung Ah Kang, Mei Jing Piao, Pincha Devage Sameera Madushan Fernando, Herath Mudiyanselage Udari Lakmini Herath, Jin Won Hyun
Article Number: 275
Published online on: 08 May 2024

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Retraction Open Access

[Retracted] Methylene blue relieves the development of osteoarthritis by upregulating lncRNA MEG3

Xinyi Li, Chaoliang Tang, Jin Wang, Peipei Guo, Chengyao Wang, Yanlin Wang, Zongze Zhang, Huisheng Wu
Article Number: 274
Published online on: 08 May 2024

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Case Report Open Access

Osimertinib‑induced erythromelalgia: A case report

Anna Bolzon, Alessia Guidotti, Mauro Alessandro Salvatore Alaibac
Article Number: 273
Published online on: 02 May 2024

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Retraction Open Access

[Retracted] Long non‑coding RNA receptor activator of nuclear factor‑κB ligand promotes cisplatin resistance in non‑small cell lung cancer cells

Zhongcheng Zhu, Xiaoyi Gong, Jing Li, Yufeng Shi, Mingyun Zhang
Article Number: 272
Published online on: 01 May 2024

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Review Open Access

Exploring the pathogenetic mechanisms of Mycoplasma pneumoniae (Review)

Vasiliki Epameinondas Georgakopoulou, Ioannis G. Lempesis, Pagona Sklapani, Nikolaos Trakas, Demetrios A. Spandidos
Article Number: 271
Published online on: 30 April 2024

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Journal Cover
March-2026 Volume 31 Issue 3

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Impact Factor: 2.3

Article Open Access

Effect of SGLT2 inhibitors on heart failure outcomes in patients with and without diabetes: A systematic review and meta‑analysis of randomized controlled trials

Duaa Abdullah Bafail, Noura Hamdi Alhalees
Article Number: 84
Published online on: 28 January 2026

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Article Open Access

Exploring the protective mechanisms and therapeutic potential of carnosic acid against acute respiratory distress syndrome through molecular docking, molecular dynamics and experimental verification

Quan Li, Lili Ding, Haijun Sun, Weichao Ding, Mengmeng Wang, Zhaorui Sun, Congxue Ma
Article Number: 83
Published online on: 28 January 2026

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Review

Exploring the roots of schizophrenia: Current research and future directions (Review)

Shuang Lv, Chunxia Luo
Article Number: 82
Published online on: 28 January 2026

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Correction Open Access

[Corrigendum] miR‑146a‑5p protects against renal injury in MRL/lpr mice via improvement of the Treg/Th17 imbalance by targeting the TRAF6/NF‑κB axis

Jiajia Teng, Feng Yang, Xiaoling Li
Article Number: 81
Published online on: 28 January 2026

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Retraction Open Access

[Retracted] MicroRNA‑24‑3p inhibition prevents cell growth of vascular smooth muscle cells by targeting Bcl‑2‑like protein 11

Huanxin Zhang, Shizhen Xue, Yi Feng, Jun Shen, Jixian Zhao
Article Number: 80
Published online on: 26 January 2026

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Article Open Access

Efficacy and safety of unilateral biportal endoscopy vs. percutaneous endoscopic interlaminar approach in lumbar disc herniation: A meta‑analysis​

Yuhao Gao, Fangzheng He, Ji Wen, Shilei Qin, Pengfei Han, Yunfeng Xu
Article Number: 79
Published online on: 23 January 2026

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Case Report Open Access

Intralobar pulmonary sequestration coexisting with pulmonary cryptococcosis: A case report and literature review

Dan Cheng, Yue Wang, Jun Li, Dan Yu, Yunyun Wang, Jinbo Fan, Jiankun Wang, Liqun He
Article Number: 78
Published online on: 23 January 2026

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Article Open Access

Tumor‑associated macrophages suppress estrogen receptor‑β expression in triple‑negative breast cancer through the PI3K/AKT pathway

Qiulei Zhang, Di Guo, Gaoran Xu, Rong Xie, Yuqing Deng, Peng Fu, Jinnan Wan
Article Number: 77
Published online on: 21 January 2026

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Article Open Access

Development of a diagnostic model for esophageal achalasia assessed by esophageal high‑resolution manometry using artificial intelligence

Maiko Tabuchi, Yasuhiko Nakao, Hitomi Minami, Hiroko Inomata, Junya Shiota, Taro Akashi, Keiichi Hashiguchi, Moto Kitayama, Kayoko Matsushima, Naoyuki Yamaguchi, Yuko Akazawa, Hisamitsu Miyaaki
Article Number: 76
Published online on: 21 January 2026

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Case Report

Use of metagenomic next‑generation sequencing to diagnose Tropheryma whipplei infection‑related pneumonia: A case report

Yutu Luo, Haibing Ding, Jiahua Pan, Guangyang Xu
Article Number: 75
Published online on: 21 January 2026

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Article Open Access

Effect of rivaroxaban on DNA damage in an ischemia-reperfusion model: Evaluation of 8‑OHdG levels

Ceren Sayarer, Abidin Cenk Erdal, Tuğra Gençpinar, Özlem Gürsoy Doruk, Tuncay Küme
Article Number: 74
Published online on: 21 January 2026

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Correction Open Access

[Corrigendum] Hepatoprotective activity of chrysin is mediated through TNF‑α in chemically‑induced acute liver damage: An in vivo study and molecular modeling 

Anca Hermenean, Teodora Mariasiu, Inmaculada Navarro-González, Josefina Vegara-Meseguer, Eftimie Miuțescu, Sandipan Chakraborty, Horacio Pérez-Sánchez
Article Number: 73
Published online on: 21 January 2026

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Retraction Open Access

[Retracted] Gambogic acid suppresses colon cancer cell activity in vitro

Zailong Zhou, Jian Ma
Article Number: 72
Published online on: 19 January 2026

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Case Report

Identification of a novel KISS1R (GPR54) gene variant (c.505+2T>G) in a patient with congenital hypogonadotropic hypogonadism: A case report and literature review

Burak Menekse, Enes Ucgul, Abdullatif Bakir, Sema Hepsen, Ilknur Ozturk Unsal, Muhammed Kizilgul, Takako Araki, Erman Cakal
Article Number: 71
Published online on: 16 January 2026

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Case Report Open Access

Postoperative hypofractionated intensity-modulated proton therapy to control recurrent paraganglioma at the jugular foramen: A case report and literature review

Wei Wang, Yingxia Yuan, Jiwei Bai, Yue Zou, Dongxue Zhou, Jun Zhao, Shuyan Zhang, Zishen Wang, Jie Wang, Jingjing Kong, Lu Yang, Masashi Mizumoto, Hideyuki Sakurai, Shosei Shimizu
Article Number: 70
Published online on: 16 January 2026

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Article

Serum antithrombin III level predicts acute kidney injury in patients with traumatic brain injury

Ruoran Wang, Min He, Jianguo Xu
Article Number: 69
Published online on: 16 January 2026

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Retraction Open Access

[Retracted] β‑asarone relieves chronic unpredictable mild stress induced depression by regulating the extracellular signal‑regulated kinase signaling pathway

Haiying Dong, Weiliang Cong, Xiwen Guo, Yuhua Wang, Shengju Tong, Qiang Li, Chengchong Li
Article Number: 68
Published online on: 12 January 2026

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Case Report Open Access

Rare co‑occurrence of gastrointestinal stromal tumors and leiomyomas: A case report and review of the literature

Yu Zhang, Xiaoqiong Shi, Wenfu Xie, Meilin He, Shan Zhang, Xue Peng, Hao Lei, Xulei Li, Haiying Liu, Qiao Shu, Fangyuan Zou, Mingyong Wei
Article Number: 67
Published online on: 09 January 2026

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Article Open Access

No increased risk of hepatic enzyme abnormalities with non‑peptidic thrombopoietin receptor agonists in immune thrombocytopenia: A meta‑analysis of randomized controlled trials

Nan Shen, Rang Wu, Tiantian Lu, Song Liu, Yazhou Jiang, Jingjing Yan, Tao Ning, Chang Dong, Jianqin Li, Suyue Zhu
Article Number: 66
Published online on: 09 January 2026

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Case Report

Submucosal colonic fecalith mimicking a submucosal malignant tumor at the anastomotic site after colon cancer: A case report

Motoaki Yuhi, Masatsugu Hiraki, Shin Takesue, Mariko Hashiguchi, Megumi Nishiyama, Yoshiaki Egashira, Tatsuya Manabe, Hirokazu Noshiro
Article Number: 65
Published online on: 08 January 2026

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Article

Clinical characteristics of acute primary angle closure following COVID‑19 during the Omicron outbreak in China

Jianhui Zhang, Yingying Xue, Liu Zhang, Yuhong Wang, Shancheng Si
Article Number: 64
Published online on: 09 January 2026

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Retraction Open Access

[Retracted] Aberrant expression and mechanism of miR‑130b‑3p/phosphatase and tensin homolog in nephroblastoma in children

Yifeng Hu, Jingtie Yan
Article Number: 63
Published online on: 05 January 2026

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Case Report Open Access

Novel variants in STAG2 and PKD1 associate with multiple congenital malformations and autosomal dominant polycystic kidney disease in a Chinese family: A case report and literature review

Qi Yang, Qiang Zhang, Sheng Yi, Xunzhao Zhou, Yiyan Ruan, Shujie Zhang, Shang Yi, Qinle Zhang, Zailng Qin, Jingsi Luo
Article Number: 62
Published online on: 30 December 2025

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Journal Cover
April-2026 Volume 31 Issue 4

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Impact Factor: 2.3

Case Report

Sagittal sinus thrombosis in pregnancy: A case report

Zaheera Saadia, Misbah Ilyas, Jayd Saud Althwiny, Fai Alaqel, Alanoud Abdullah Alsufayri, Lujain Husain Almutairi
Article Number: 100
Published online on: 05 February 2026

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Article

Elevated PGE2 and COX‑2 expression in villous adenoma: Implications for electrolyte depletion syndrome

Shiki Fujino, Hiroyuki Fukuda, Katsuki Danno, Takashi Takeda, Masaya Higashiguchi, Kozo Noguchi, Takefumi Hirao, Aya Ito, Norikatsu Miyoshi, Yoshio Oka
Article Number: 99
Published online on: 04 February 2026

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Article Open Access

Wogonin as a potential therapeutic agent for psoriasis: Core target identification and validation

Yu Lu, Xiaomei Zhou, Yiyu Guo, Fengrui Zhang, Jirong Wang, Jinhong Ge, Yan Xiao, Dengke Yang
Article Number: 98
Published online on: 04 February 2026

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Expression of Concern Open Access

[Expression of Concern] Glibenclamide exacerbates adriamycin‑induced cardiotoxicity by activating oxidative stress‑induced endoplasmic reticulum stress in rats

Meng-Lin Liu, Meng-Long Wang, Jing-Jun Lv, Jie Wei, Jun Wan
Article Number: 97
Published online on: 04 February 2026

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Review

Key role of the autonomic nervous system in breast cancer (Review)

Min Wu, Zhiwu Zhang, Lu Zhou, Shiqi Liu, Qing Chen, Cui Guo, Shasha Zhao, Xuedan Chen
Article Number: 96
Published online on: 04 February 2026

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Review Open Access

Senescent hepatic stellate cells drive inflammation and disease progression in MASH (Review)

Zhiqi Han, Yiran She, Di Wu, Nuo Zhang, Zheyuan Liu, Zhongyuan Wang, Xiaoying Zhou, Shuo Li
Article Number: 95
Published online on: 04 February 2026

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Article Open Access

PUM2 knockdown regulates the expression and alternative splicing of genes associated with myocardial fibrosis in H9C2 cells

Zilong Zhang, Hangyu Zhou, Diliyaer Adili, Wei Zhu, Yong Liu, Wenzheng Zhou, Zhao Wang, Jie Li
Article Number: 94
Published online on: 04 February 2026

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Case Report

A novel human papillomavirus‑induced ‘doughnut wart’ lesion treated with 5‑aminolevulinic acid photodynamic therapy: A case report

Ke Li, Yitao Qian, Wenjing Zha, Lei Shi
Article Number: 93
Published online on: 04 February 2026

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Case Report Open Access

Comprehensive diagnosis and individualized treatment of multiple primary lung cancer: A case report

Guoxiong Zeng, Yunyan Zhou, Wang Wan, Biao Deng, Chunyuan Chen, Zhu Liang
Article Number: 92
Published online on: 03 February 2026

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Review Open Access

Pathophysiological mechanisms of fatigue and multidisciplinary management strategies (Review)

Hong Zhou, Wenwen Yu, Jiaming Lei, Runzhi Chang, Yingjia Cheng, Guorui Wang, Li Lin
Article Number: 91
Published online on: 03 February 2026

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Case Report Open Access

A rare upstream regulatory region mutation in APC presenting as classical familial adenomatous polyposis: A case report and literature review

Chi-Han Yang, Yen-Cheng Chen, Tsung-Kun Chang, Wei-Chih Su, Ching-Wen Huang, Hsiang-Lin Tsai, Jaw-Yuan Wang
Article Number: 90
Published online on: 02 February 2026

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Retraction Open Access

[Retracted] lncRNA MIAT promote cell invasion and migration in esophageal cancer

Weiguo Zhang, Qiang Chen, Caipeng Lei
Article Number: 89
Published online on: 02 February 2026

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Review Open Access

Mitochondria‑driven ferroptosis in intervertebral disc degeneration: A novel target in age‑related spinal diseases (Review)

Yang Hou, Xiaolei Yang, Duorun Qiu, Lei Liu, Jiangang Shi, Yongfei Guo
Article Number: 88
Published online on: 02 February 2026

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Case Report

Preoperative treatment with thyroid artery embolization in a patient with a giant retrosternal goiter causing severe tracheal compression: A case report

Jingxian Li, Fang Wang, Yuanshu Du, Yonghui Wang
Article Number: 87
Published online on: 02 February 2026

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Case Report Open Access

Gastric wall thickening and gastric outlet obstruction due to peritoneal metastasis in breast cancer: A case report

Bin He, Lin Ling Li, Ting Yu, Yu Tan, Ling Zhang
Article Number: 86
Published online on: 29 January 2026

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Article Open Access

Myrrh ameliorates endometriosis by enhancing ER stress‑related apoptotic cell death

Bo-Sung Kim, Minkyoung Cho, Jung Ho Han, Jung-Sook Jin, Sung-Jin Bae, Yunju Jo, Dongryeol Ryu, Yerim Joo, Seon Beom Kim, Jongkil Joo, Inhye Kim, Ki-Tae Ha
Article Number: 85
Published online on: 29 January 2026

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