Open Access

Effects of extracellular vesicles for ischemic stroke: A meta‑analysis of preclinical studies

  • Authors:
    • Yuan Xie
    • Tianhao Deng
    • Le Xie
    • Yao Xie
    • Jiaqi Ma
    • Don Zhong
    • Xiongying Huang
    • Yingchen Li
  • View Affiliations

  • Published online on: May 16, 2024     https://doi.org/10.3892/etm.2024.12575
  • Article Number: 287
  • Copyright: © Xie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Ischemic stroke is a common occurrence worldwide, posing a severe threat to human health and leading to negative financial impacts. Currently available treatments still have numerous limitations. As research progresses, extracellular vesicles are being found to have therapeutic potential in ischemic stroke. In the present study, the literature on extracellular vesicle therapy in animal studies of ischemic stroke was screened by searching databases, including PubMed, Embase, Medline, Web of Science and the Cochrane Library. The main outcomes of the present study were the neurological function score, apoptotic rate and infarct volumes. The secondary outcomes were pro‑inflammatory factors, including tumor necrosis factor‑α (TNF‑α), interleukin (IL)‑1β and IL‑6. The study quality was assessed using the CAMARADES Checklist. Subgroup analyses were performed to evaluate factors influencing extracellular vesicle therapy. Review Man3ager5.3 was used for data analysis. A total of 20 relevant articles were included in the present meta‑analysis. The comprehensive analysis revealed that extracellular vesicles exerted a significant beneficial effect on neurobehavioral function, reducing the infarct volume and decreasing the apoptotic rate. Moreover, extracellular vesicles were found to promote nerve recovery by inhibiting pro‑inflammatory factors (TNF‑α, IL‑1β and IL‑6). On the whole, the present meta‑analysis examined the combined effects of extracellular vesicles on nerve function, infarct volume, apoptosis and inflammation, which provides a foundation for the clinical study of extracellular vesicles.
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July-2024
Volume 28 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Xie Y, Deng T, Xie L, Xie Y, Ma J, Zhong D, Huang X and Li Y: Effects of extracellular vesicles for ischemic stroke: A meta‑analysis of preclinical studies. Exp Ther Med 28: 287, 2024.
APA
Xie, Y., Deng, T., Xie, L., Xie, Y., Ma, J., Zhong, D. ... Li, Y. (2024). Effects of extracellular vesicles for ischemic stroke: A meta‑analysis of preclinical studies. Experimental and Therapeutic Medicine, 28, 287. https://doi.org/10.3892/etm.2024.12575
MLA
Xie, Y., Deng, T., Xie, L., Xie, Y., Ma, J., Zhong, D., Huang, X., Li, Y."Effects of extracellular vesicles for ischemic stroke: A meta‑analysis of preclinical studies". Experimental and Therapeutic Medicine 28.1 (2024): 287.
Chicago
Xie, Y., Deng, T., Xie, L., Xie, Y., Ma, J., Zhong, D., Huang, X., Li, Y."Effects of extracellular vesicles for ischemic stroke: A meta‑analysis of preclinical studies". Experimental and Therapeutic Medicine 28, no. 1 (2024): 287. https://doi.org/10.3892/etm.2024.12575