Papillary adenoma of the lung: A case report and literature review

Chen,Li-Qian; Yang,Mai-Qing; Gao,Su-Mei; Wang,Zheng-Jiang; Xu,Hong-Tao

doi:10.3892/etm.2024.12658

Papillary adenoma of the lung: A case report and literature review

Authors:
- Li-Qian Chen
- Mai-Qing Yang
- Su-Mei Gao
- Zheng-Jiang Wang
- Hong-Tao Xu
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Affiliations: Department of Pathology, Weifang People's Hospital (First Affiliated Hospital of Shandong Second Medical University), Weifang, Shandong 261041, P.R. China, Department of Pathology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China
Published online on: July 16, 2024 https://doi.org/10.3892/etm.2024.12658
Article Number: 369
Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Papillary adenoma of the lung, a rare and benign tumor, is easily confused with other primary benign or malignant lung tumors and especially with lung adenocarcinoma that has a papillary growth pattern. Enhanced understanding and an accurate diagnosis of papillary adenomas of the lung are crucial for clinical treatment and prognostic assessment. A 61‑year‑old man who presented with an opportunistic finding in relation to a left lower lobe lung nodule during an examination was admitted to The First Hospital of China Medical University (Shenyang, China) for further treatment. Computed tomography (CT) revealed a well‑circumscribed left lower lobe nodule (diameter, ~1 cm), comprising branched papillae with a fibrovascular core and no other structural components. The tumor cells appeared relatively uniform in shape and well arranged with round or oval nuclei. No nucleoli or mitotic figures were observed. Immunohistochemically, the papillary structures of the tumor cells were strongly and diffusely positive for cytokeratin (CK), CK7, Napsin‑A and thyroid transcription factor 1. The Ki‑67 index was ~1%. A pathological diagnosis of primary papillary adenoma of the lung was made based on these findings. A left lower‑lobe wedge resection was performed and the patient's postoperative course was uneventful. Surgical resection is the preferred treatment. Papillary adenoma of the lung is very rare, and its clinical manifestations and CT images are non‑specific. It is important to avoid misdiagnosing of papillary adenoma of the lung as another type of lung tumor, especially adenocarcinoma. A clear understanding of the morphological and immunohistochemical features of papillary adenomas is important for the diagnosis of this rare lung tumor.

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