Open Access

Peptic ulcer induced by immune checkpoint inhibitors successfully treated with glucocorticoids: A report of three cases and a literature review

  • Authors:
    • Qingzhe Wang
    • Min Yu
    • Shuang Zhang
  • View Affiliations

  • Published online on: August 28, 2024     https://doi.org/10.3892/etm.2024.12699
  • Article Number: 410
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

In recent decades, immune checkpoint inhibitors (ICIs) have emerged as safer and less disruptive alternatives to conventional chemotherapy and radiotherapy for certain patients with tumours. ICIs serve a synergistic role alongside conventional therapies by manipulating the immune system to recognise and target tumour cells. However, excessive activation of the immune system can lead to immune‑related adverse events including pneumonia, myocarditis and colitis, which pose serious and even fatal risks. In the present case series, three patients with a thoracic tumour with an ICI‑induced peptic ulcer triggered by programmed cell death protein 1 antibodies (diagnosed by gastrointestinal endoscopy) are presented. These cases were successfully treated with corticosteroids. The diagnostic and treatment processes undertaken for these patients underscore the requirement to comprehensively understand the mechanism of ICI‑induced peptic ulcer. Moreover, the relevant literature was also reviewed in the present study. 
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November-2024
Volume 28 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Wang Q, Yu M and Zhang S: Peptic ulcer induced by immune checkpoint inhibitors successfully treated with glucocorticoids: A report of three cases and a literature review. Exp Ther Med 28: 410, 2024.
APA
Wang, Q., Yu, M., & Zhang, S. (2024). Peptic ulcer induced by immune checkpoint inhibitors successfully treated with glucocorticoids: A report of three cases and a literature review. Experimental and Therapeutic Medicine, 28, 410. https://doi.org/10.3892/etm.2024.12699
MLA
Wang, Q., Yu, M., Zhang, S."Peptic ulcer induced by immune checkpoint inhibitors successfully treated with glucocorticoids: A report of three cases and a literature review". Experimental and Therapeutic Medicine 28.5 (2024): 410.
Chicago
Wang, Q., Yu, M., Zhang, S."Peptic ulcer induced by immune checkpoint inhibitors successfully treated with glucocorticoids: A report of three cases and a literature review". Experimental and Therapeutic Medicine 28, no. 5 (2024): 410. https://doi.org/10.3892/etm.2024.12699