Open Access

Neural repair function of osteopontin in stroke and stroke‑related diseases (Review)

  • Authors:
    • Xin Sun
    • Chunhao Li
  • View Affiliations

  • Published online on: October 16, 2024     https://doi.org/10.3892/etm.2024.12749
  • Article Number: 459
  • Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Stroke, including hemorrhagic stroke and ischemic stroke, is a common disease of the central nervous system. It is characterized by a high mortality and disability rate and is closely associated with atherosclerosis, hypertension hyperglycemia, atrial fibrillation and unhealthy living habits. The continuous development of surgery and medications has decreased the mortality rate of patients with stroke and has greatly improved the disease prognosis. At present, the direction of clinical treatment and research has gradually shifted to the repair of nerve function after stroke. Osteopontin (OPN) is a widely distributed extracellular matrix protein. Due to its structural characteristics, OPN can be cut and modified into terminal fragments with different functions, which play different roles in various pathophysiological processes, such as formation of tumors, inflammation and autoimmune diseases. It has also become a potential diagnostic and therapeutic marker. In order to comprehensively analyze the specific role of OPN in nerve repair and its relationship with stroke and stroke‑related diseases, the following key words were used: ‘Osteopontin, stroke, atherosis, neuroplasticity, neural repair’. PubMed, Web of Science and Cochrane articles related to OPN were searched and summarized. The present review describes the OPN structure, isoforms, functions and its neural repair mechanism, and its association with the occurrence and development of stroke and related diseases was explored.
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December-2024
Volume 28 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Sun X and Li C: Neural repair function of osteopontin in stroke and stroke‑related diseases (Review). Exp Ther Med 28: 459, 2024.
APA
Sun, X., & Li, C. (2024). Neural repair function of osteopontin in stroke and stroke‑related diseases (Review). Experimental and Therapeutic Medicine, 28, 459. https://doi.org/10.3892/etm.2024.12749
MLA
Sun, X., Li, C."Neural repair function of osteopontin in stroke and stroke‑related diseases (Review)". Experimental and Therapeutic Medicine 28.6 (2024): 459.
Chicago
Sun, X., Li, C."Neural repair function of osteopontin in stroke and stroke‑related diseases (Review)". Experimental and Therapeutic Medicine 28, no. 6 (2024): 459. https://doi.org/10.3892/etm.2024.12749