Open Access

Molecular strategies for detecting chromosomal translocations in soft tissue tumors (Review)

  • Authors:
    • Margherita Cerrone
    • Monica Cantile
    • Francesca Collina
    • Laura Marra
    • Giuseppina Liguori
    • Renato Franco
    • Annarosaria De Chiara
    • Gerardo Botti
  • View Affiliations

  • Published online on: April 4, 2014     https://doi.org/10.3892/ijmm.2014.1726
  • Pages: 1379-1391
  • Copyright: © Cerrone et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Approximately one third of soft tissue tumors are characterized by chromosomal aberrations, in particular, translocations and amplifications, which appear to be highly specific. The identification of fusion transcripts not only supports the diagnosis, but provides the basis for the development of novel therapeutic strategies aimed at blocking the aberrant activity of chimeric proteins. Molecular biology, and in particular, cytogenetic and qualitative and quantitative polymerase chain reaction technologies, allow with high efficiency and specificity, the determination of specific fusion transcripts resulting from chromosomal translocations, as well as the analysis of gene amplifications. In this review, various molecular techniques that allow the identification of translocations and consequent fusion transcripts generated are discussed in the broad spectrum of soft tissue tumors.
View Figures
View References

Related Articles

Journal Cover

June-2014
Volume 33 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Cerrone M, Cantile M, Collina F, Marra L, Liguori G, Franco R, De Chiara A and Botti G: Molecular strategies for detecting chromosomal translocations in soft tissue tumors (Review). Int J Mol Med 33: 1379-1391, 2014.
APA
Cerrone, M., Cantile, M., Collina, F., Marra, L., Liguori, G., Franco, R. ... Botti, G. (2014). Molecular strategies for detecting chromosomal translocations in soft tissue tumors (Review). International Journal of Molecular Medicine, 33, 1379-1391. https://doi.org/10.3892/ijmm.2014.1726
MLA
Cerrone, M., Cantile, M., Collina, F., Marra, L., Liguori, G., Franco, R., De Chiara, A., Botti, G."Molecular strategies for detecting chromosomal translocations in soft tissue tumors (Review)". International Journal of Molecular Medicine 33.6 (2014): 1379-1391.
Chicago
Cerrone, M., Cantile, M., Collina, F., Marra, L., Liguori, G., Franco, R., De Chiara, A., Botti, G."Molecular strategies for detecting chromosomal translocations in soft tissue tumors (Review)". International Journal of Molecular Medicine 33, no. 6 (2014): 1379-1391. https://doi.org/10.3892/ijmm.2014.1726