Interaction between angiotensin II and relaxin 2 in the progress of growth and spread of prostate cancer cells

  • Authors:
    • Kamila Domińska
    • Tomasz Ochędalski
    • Karolina Kowalska
    • Zuzanna Elżbieta Matysiak‑Burzyńska
    • Elżbieta Płuciennik
    • Agnieszka Wanda Piastowska-Ciesielska
  • View Affiliations

  • Published online on: March 24, 2016     https://doi.org/10.3892/ijo.2016.3458
  • Pages: 2619-2628
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Abstract

Deregulation of locally secreted hormones, such as angiotensin II (Ang II) and relaxin 2 (RLN2), has been linked to a higher risk of select cancers or a poor prognosis in patients. In this study, for the first time a common effect of Ang II and RLN2 in relation to various aspects of prostate cancer development and metastasis are presented. Four independent colorimetric assays were used to analyze cell viability and proliferation. The changes of cell adhesion to extracellular matrix proteins and invasion/aggressiveness ability of prostate cancer cells (LNCaP, PC3) before and after peptides treatment, were also investigated. The findings suggest that the both investigated systems, have an impact on cell growth/division or spread, to some degree via overlapping signal transduction pathways. Intermediate or sometimes poorer results were achieved by using a combination of both hormones than when each was used individually. It seems that Ang II and RLN2 can play a significant role in increasing the aggressiveness of prostate tumors by up-regulating BIRC5 expression and MMP-2 and MMP-9 secretion. In addition, we speculate that Ang II and RLN2 are involved in the transition from the androgen-dependent to the androgen-independent phenotype via modulation of the expression of androgen receptors.
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June-2016
Volume 48 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Domińska K, Ochędalski T, Kowalska K, Matysiak‑Burzyńska ZE, Płuciennik E and Piastowska-Ciesielska AW: Interaction between angiotensin II and relaxin 2 in the progress of growth and spread of prostate cancer cells. Int J Oncol 48: 2619-2628, 2016.
APA
Domińska, K., Ochędalski, T., Kowalska, K., Matysiak‑Burzyńska, Z.E., Płuciennik, E., & Piastowska-Ciesielska, A.W. (2016). Interaction between angiotensin II and relaxin 2 in the progress of growth and spread of prostate cancer cells. International Journal of Oncology, 48, 2619-2628. https://doi.org/10.3892/ijo.2016.3458
MLA
Domińska, K., Ochędalski, T., Kowalska, K., Matysiak‑Burzyńska, Z. E., Płuciennik, E., Piastowska-Ciesielska, A. W."Interaction between angiotensin II and relaxin 2 in the progress of growth and spread of prostate cancer cells". International Journal of Oncology 48.6 (2016): 2619-2628.
Chicago
Domińska, K., Ochędalski, T., Kowalska, K., Matysiak‑Burzyńska, Z. E., Płuciennik, E., Piastowska-Ciesielska, A. W."Interaction between angiotensin II and relaxin 2 in the progress of growth and spread of prostate cancer cells". International Journal of Oncology 48, no. 6 (2016): 2619-2628. https://doi.org/10.3892/ijo.2016.3458