Hostile takeover: Manipulation of HIF-1 signaling in pathogen-associated cancers (Review)

  • Authors:
    • Caixia Zhu
    • Qing Zhu
    • Chong Wang
    • Liming Zhang
    • Fang Wei
    • Qiliang Cai
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  • Published online on: July 27, 2016     https://doi.org/10.3892/ijo.2016.3633
  • Pages: 1269-1276
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Abstract

Hypoxia-inducible factor (HIF)-1 is a central regulator in the adaptation process of cell response to hypoxia (low oxygen). Emerging evidence has demonstrated that HIF-1 plays an important role in the development and progression of many types of human diseases, including pathogen-associated cancers. In the present review, we summarize the recent understandings of how human pathogenic agents including viruses, bacteria and parasites deregulate cellular HIF-1 signaling pathway in their associated cancer cells, and highlight the common molecular mechanisms of HIF-1 signaling activated by these pathogenic infection, which could act as potential diagnostic markers and new therapeutic strategies against human infectious cancers.
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October-2016
Volume 49 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Zhu C, Zhu Q, Wang C, Zhang L, Wei F and Cai Q: Hostile takeover: Manipulation of HIF-1 signaling in pathogen-associated cancers (Review). Int J Oncol 49: 1269-1276, 2016.
APA
Zhu, C., Zhu, Q., Wang, C., Zhang, L., Wei, F., & Cai, Q. (2016). Hostile takeover: Manipulation of HIF-1 signaling in pathogen-associated cancers (Review). International Journal of Oncology, 49, 1269-1276. https://doi.org/10.3892/ijo.2016.3633
MLA
Zhu, C., Zhu, Q., Wang, C., Zhang, L., Wei, F., Cai, Q."Hostile takeover: Manipulation of HIF-1 signaling in pathogen-associated cancers (Review)". International Journal of Oncology 49.4 (2016): 1269-1276.
Chicago
Zhu, C., Zhu, Q., Wang, C., Zhang, L., Wei, F., Cai, Q."Hostile takeover: Manipulation of HIF-1 signaling in pathogen-associated cancers (Review)". International Journal of Oncology 49, no. 4 (2016): 1269-1276. https://doi.org/10.3892/ijo.2016.3633