Cell division cycle associated 1 as a novel prognostic biomarker and therapeutic target for oral cancer

  • Authors:
    • Phung Manh Thang
    • Atsushi Takano
    • Yoshihiro Yoshitake
    • Masanori Shinohara
    • Yoshinori Murakami
    • Yataro Daigo
  • View Affiliations

  • Published online on: August 5, 2016     https://doi.org/10.3892/ijo.2016.3649
  • Pages: 1385-1393
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Abstract

Oral cavity carcinoma (OCC) is one of the most common causes of cancer-related death worldwide and has poor clinical outcome after standard therapies. Therefore, new prognostic biomarkers and therapeutic targets for OCC are urgently needed. We selected cell division cycle associated 1 (CDCA1) as a candidate OCC biomarker. Immunohistochemical analysis confirmed that CDCA1 protein was expressed in 67 of 99 OCC tissues (67.7%), but not in healthy oral epithelia. CDCA1 expression was significantly associated with poor prognosis in OCC patients (P=0.0244). Knockdown of CDCA1 by siRNAs significantly increased apoptosis of tumor cells. These data suggest that CDCA1 represents a novel prognostic biomarker and therapeutic target for OCC.
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October-2016
Volume 49 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Thang PM, Takano A, Yoshitake Y, Shinohara M, Murakami Y and Daigo Y: Cell division cycle associated 1 as a novel prognostic biomarker and therapeutic target for oral cancer. Int J Oncol 49: 1385-1393, 2016.
APA
Thang, P.M., Takano, A., Yoshitake, Y., Shinohara, M., Murakami, Y., & Daigo, Y. (2016). Cell division cycle associated 1 as a novel prognostic biomarker and therapeutic target for oral cancer. International Journal of Oncology, 49, 1385-1393. https://doi.org/10.3892/ijo.2016.3649
MLA
Thang, P. M., Takano, A., Yoshitake, Y., Shinohara, M., Murakami, Y., Daigo, Y."Cell division cycle associated 1 as a novel prognostic biomarker and therapeutic target for oral cancer". International Journal of Oncology 49.4 (2016): 1385-1393.
Chicago
Thang, P. M., Takano, A., Yoshitake, Y., Shinohara, M., Murakami, Y., Daigo, Y."Cell division cycle associated 1 as a novel prognostic biomarker and therapeutic target for oral cancer". International Journal of Oncology 49, no. 4 (2016): 1385-1393. https://doi.org/10.3892/ijo.2016.3649