Effect of resveratrol on cancer progression through the REG Ⅲ expression pathway in head and neck cancer cells
- Authors:
- Shinji Mikami
- Ichiro Ota
- Takashi Masui
- Asako Itaya‑Hironaka
- Ryogo Shobatake
- Hideyuki Okamoto
- Shin Takasawa
- Tadashi Kitahara
-
Affiliations: Department of Otolaryngology‑Head and Neck Surgery, Nara Medical University, Kashihara, Nara 634‑8522, Japan, Department of Biochemistry, Nara Medical University, Kashihara, Nara 634‑8522, Japan, Department of Otolaryngology, Nara City Hospital, Nara 630‑8305, Japan - Published online on: August 19, 2016 https://doi.org/10.3892/ijo.2016.3664
- Pages: 1553-1560
This article is mentioned in:
Abstract
Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar | |
Siegel R, Ma J, Zou Z and Jemal A: Cancer statistics, 2014. CA Cancer J Clin. 64:9–29. 2014. View Article : Google Scholar : PubMed/NCBI | |
Argiris A, Karamouzis MV, Raben D and Ferris RL: Head and neck cancer. Lancet. 371:1695–1709. 2008. View Article : Google Scholar : PubMed/NCBI | |
Pignon JP, le Maître A, Maillard E and Bourhis J; MACH-NC Collaborative Group. Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 93 randomised trials and 17,346 patients. Radiother Oncol. 92:4–14. 2009. View Article : Google Scholar : PubMed/NCBI | |
Ozer E, Grecula JC, Agrawal A, Rhoades CA, Young DC and Schuller DE: Long-term results of a multimodal intensification regimen for previously untreated advanced resectable squamous cell cancer of the oral cavity, oropharynx, or hypopharynx. Laryngoscope. 116:607–612. 2006. View Article : Google Scholar : PubMed/NCBI | |
Ang KK, Trotti A, Brown BW, Garden AS, Foote RL, Morrison WH, Geara FB, Klotch DW, Goepfert H and Peters LJ: Randomized trial addressing risk features and time factors of surgery plus radiotherapy in advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys. 51:571–578. 2001. View Article : Google Scholar : PubMed/NCBI | |
Cooper JS, Zhang Q, Pajak TF, Forastiere AA, Jacobs J, Saxman SB, Kish JA, Kim HE, Cmelak AJ, Rotman M, et al: Long-term follow-up of the RTOG 9501/intergroup phase III trial: Postoperative concurrent radiation therapy and chemotherapy in high-risk squamous cell carcinoma of the head and neck. Int J Radiat Oncol Biol Phys. 84:1198–1205. 2012. View Article : Google Scholar : PubMed/NCBI | |
Adelstein DJ, Saxton JP, Rybicki LA, Esclamado RM, Wood BG, Strome M, Lavertu P, Lorenz RR and Carroll MA: Multiagent concurrent chemoradiotherapy for locoregionally advanced squamous cell head and neck cancer: Mature results from a single institution. J Clin Oncol. 24:1064–1071. 2006. View Article : Google Scholar : PubMed/NCBI | |
Goldenberg D, Lee J, Koch WM, Kim MM, Trink B, Sidransky D and Moon CS: Habitual risk factors for head and neck cancer. Otolaryngol Head Neck Surg. 131:986–993. 2004. View Article : Google Scholar : PubMed/NCBI | |
Kumar B, Cordell KG, Lee JS, Worden FP, Prince ME, Tran HH, Wolf GT, Urba SG, Chepeha DB, Teknos TN, et al: EGFR, p16, HPV Titer, Bcl-xL and p53, sex, and smoking as indicators of response to therapy and survival in oropharyngeal cancer. J Clin Oncol. 26:3128–3137. 2008. View Article : Google Scholar : PubMed/NCBI | |
Worden FP, Kumar B, Lee JS, Wolf GT, Cordell KG, Taylor JM, Urba SG, Eisbruch A, Teknos TN, Chepeha DB, et al: Chemo-selection as a strategy for organ preservation in advanced oropharynx cancer: Response and survival positively associated with HPV16 copy number. J Clin Oncol. 26:3138–3146. 2008. View Article : Google Scholar : PubMed/NCBI | |
Shiboski CH, Schmidt BL and Jordan RC: Tongue and tonsil carcinoma: Increasing trends in the U.S. population ages 20–44 years. Cancer. 103:1843–1849. 2005. View Article : Google Scholar : PubMed/NCBI | |
Takasawa S: Regenerating gene (REG) product and its potential clinical usage. Expert Opin Ther Targets. 20:541–550. 2016. View Article : Google Scholar | |
Watanabe T, Yonekura H, Terazono K, Yamamoto H and Okamoto H: Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The reg protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene. J Biol Chem. 265:7432–7439. 1990.PubMed/NCBI | |
Fukui H, Kinoshita Y, Maekawa T, Okada A, Waki S, Hassan S, Okamoto H and Chiba T: Regenerating gene protein may mediate gastric mucosal proliferation induced by hypergastrinemia in rats. Gastroenterology. 115:1483–1493. 1998. View Article : Google Scholar : PubMed/NCBI | |
Higham AD, Bishop LA, Dimaline R, Blackmore CG, Dobbins AC, Varro A, Thompson DG and Dockray GJ: Mutations of RegIalpha are associated with enterochromaffin-like cell tumor development in patients with hypergastrinemia. Gastroenterology. 116:1310–1318. 1999. View Article : Google Scholar : PubMed/NCBI | |
Shinozaki S, Nakamura T, Iimura M, Kato Y, Iizuka B, Kobayashi M and Hayashi N: Upregulation of Reg 1α and GW112 in the epithelium of inflamed colonic mucosa. Gut. 48:623–629. 2001. View Article : Google Scholar : PubMed/NCBI | |
Ose T, Kadowaki Y, Fukuhara H, Kazumori H, Ishihara S, Udagawa J, Otani H, Takasawa S, Okamoto H and Kinoshita Y: Reg I-knockout mice reveal its role in regulation of cell growth that is required in generation and maintenance of the villous structure of small intestine. Oncogene. 26:349–359. 2007. View Article : Google Scholar | |
Zhang YW, Ding LS and Lai MD: Reg gene family and human diseases. World J Gastroenterol. 9:2635–2641. 2003. View Article : Google Scholar : PubMed/NCBI | |
Zhao J, Wang J, Wang H and Lai M: Reg proteins and their roles in inflammation and cancer of the human digestive system. Adv Clin Chem. 61:153–173. 2013. View Article : Google Scholar : PubMed/NCBI | |
Terazono K, Yamamoto H, Takasawa S, Shiga K, Yonemura Y, Tochino Y and Okamoto H: A novel gene activated in regenerating islets. J Biol Chem. 263:2111–2114. 1988.PubMed/NCBI | |
Moriizumi S, Watanabe T, Unno M, Nakagawara K, Suzuki Y, Miyashita H, Yonekura H and Okamoto H: Isolation, structural determination and expression of a novel reg gene, human regI β. Biochim Biophys Acta. 1217:199–202. 1994. View Article : Google Scholar : PubMed/NCBI | |
Sanchez D, Figarella C, Marchand-Pinatel S, Bruneau N and Guy-Crotte O: Preferential expression of reg I β gene in human adult pancreas. Biochem Biophys Res Commun. 284:729–737. 2001. View Article : Google Scholar : PubMed/NCBI | |
Hervieu V, Christa L, Gouysse G, Bouvier R, Chayvialle JA, Bréchot C and Scoazec JY: HIP/PAP, a member of the reg family, is expressed in glucagon-producing enteropancreatic endocrine cells and tumors. Hum Pathol. 37:1066–1075. 2006. View Article : Google Scholar : PubMed/NCBI | |
Drickamer K: Two distinct classes of carbohydrate-recognition domains in animal lectins. J Biol Chem. 263:9557–9560. 1988.PubMed/NCBI | |
Dusetti NJ, Frigerio JM, Fox MF, Swallow DM, Dagorn JC and Iovanna JL: Molecular cloning, genomic organization, and chromosomal localization of the human pancreatitis-associated protein (PAP) gene. Genomics. 19:108–114. 1994. View Article : Google Scholar : PubMed/NCBI | |
Lasserre C, Simon MT, Ishikawa H, Diriong S, Nguyen VC, Christa L, Vernier P and Brechot C: Structural organization and chromosomal localization of a human gene (HIP/PAP) encoding a C-type lectin overexpressed in primary liver cancer. Eur J Biochem. 224:29–38. 1994. View Article : Google Scholar : PubMed/NCBI | |
Nata K, Liu Y, Xu L, Ikeda T, Akiyama T, Noguchi N, Kawaguchi S, Yamauchi A, Takahashi I, Shervani NJ, et al: Molecular cloning, expression and chromosomal localization of a novel human REG family gene, REG III. Gene. 340:161–170. 2004. View Article : Google Scholar : PubMed/NCBI | |
Hartupee JC, Zhang H, Bonaldo MF, Soares MB and Dieckgraefe BK: Isolation and characterization of a cDNA encoding a novel member of the human regenerating protein family: Reg IV. Biochim Biophys Acta. 1518:287–293. 2001. View Article : Google Scholar : PubMed/NCBI | |
Watanabe T, Yonemura Y, Yonekura H, Suzuki Y, Miyashita H, Sugiyama K, Moriizumi S, Unno M, Tanaka O and Kondo H: Pancreatic beta-cell replication and amelioration of surgical diabetes by Reg protein. Proc Natl Acad Sci USA. 91:3589–3592. 1994. View Article : Google Scholar : PubMed/NCBI | |
Asahara M, Mushiake S, Shimada S, Fukui H, Kinoshita Y, Kawanami C, Watanabe T, Tanaka S, Ichikawa A, Uchiyama Y, et al: Reg gene expression is increased in rat gastric enterochromaffin-like cells following water immersion stress. Gastroenterology. 111:45–55. 1996. View Article : Google Scholar : PubMed/NCBI | |
Macadam RC, Sarela AI, Farmery SM, Robinson PA, Markham AF and Guillou PJ: Death from early colorectal cancer is predicted by the presence of transcripts of the REG gene family. Br J Cancer. 83:188–195. 2000.PubMed/NCBI | |
Violette S, Festor E, Pandrea-Vasile I, Mitchell V, Adida C, Dussaulx E, Lacorte JM, Chambaz J, Lacasa M and Lesuffleur T: Reg IV, a new member of the regenerating gene family, is overexpressed in colorectal carcinomas. Int J Cancer. 103:185–193. 2003. View Article : Google Scholar | |
Oue N, Mitani Y, Aung PP, Sakakura C, Takeshima Y, Kaneko M, Noguchi T, Nakayama H and Yasui W: Expression and localization of Reg IV in human neoplastic and non-neoplastic tissues: Reg IV expression is associated with intestinal and neuroendocrine differentiation in gastric adenocarcinoma. J Pathol. 207:185–198. 2005. View Article : Google Scholar : PubMed/NCBI | |
Yonemura Y, Sakurai S, Yamamoto H, Endou Y, Kawamura T, Bandou E, Elnemr A, Sugiyama K, Sasaki T, Akiyama T, et al: REG gene expression is associated with the infiltrating growth of gastric carcinoma. Cancer. 98:1394–1400. 2003. View Article : Google Scholar : PubMed/NCBI | |
Dhar DK, Udagawa J, Ishihara S, Otani H, Kinoshita Y, Takasawa S, Okamoto H, Kubota H, Fujii T, Tachibana M, et al: Expression of regenerating gene I in gastric adenocarcinomas: Correlation with tumor differentiation status and patient survival. Cancer. 100:1130–1136. 2004. View Article : Google Scholar : PubMed/NCBI | |
Bishnupuri KS, Luo Q, Murmu N, Houchen CW, Anant S and Dieckgraefe BK: Reg IV activates the epidermal growth factor receptor/Akt/AP-1 signaling pathway in colon adenocarcinomas. Gastroenterology. 130:137–149. 2006. View Article : Google Scholar : PubMed/NCBI | |
Hayashi K, Motoyama S, Koyota S, Koizumi Y, Wang J, Takasawa S, Itaya-Hironaka A, Sakuramoto-Tsuchida S, Maruyama K, Saito H, et al: REG I enhances chemo- and radiosensitivity in squamous cell esophageal cancer cells. Cancer Sci. 99:2491–2495. 2008. View Article : Google Scholar : PubMed/NCBI | |
Zhou L, Zhang R, Wang L, Shen S, Okamoto H, Sugawara A, Xia L, Wang X, Noguchi N, Yoshikawa T, et al: Upregulation of REG Ialpha accelerates tumor progression in pancreatic cancer with diabetes. Int J Cancer. 127:1795–1803. 2010. View Article : Google Scholar : PubMed/NCBI | |
Fukui H, Fujii S, Takeda J, Kayahara T, Sekikawa A, Nanakin A, Suzuki K, Hisatsune H, Seno H, Sawada M, et al: Expression of reg I α protein in human gastric cancers. Digestion. 69:177–184. 2004. View Article : Google Scholar | |
Minamiya Y, Kawai H, Saito H, Ito M, Hosono Y, Motoyama S, Katayose Y, Takahashi N and Ogawa J: REG1A expression is an independent factor predictive of poor prognosis in patients with non-small cell lung cancer. Lung Cancer. 60:98–104. 2008. View Article : Google Scholar | |
Mauro V, Carette D, Chevallier D, Michiels JF, Segretain D, Pointis G and Sénégas-Balas F: Reg I protein in healthy and seminoma human testis. Histol Histopathol. 23:1195–1203. 2008.PubMed/NCBI | |
Kimura M, Naito H, Tojo T, Itaya-Hironaka A, Dohi Y, Yoshimura M, Nakagawara K, Takasawa S and Taniguchi S: REG Iα gene expression is linked with the poor prognosis of lung adenocarcinoma and squamous cell carcinoma patients via discrete mechanisms. Oncol Rep. 30:2625–2631. 2013.PubMed/NCBI | |
Masui T, Ota I, Itaya-Hironaka A, Takeda M, Kasai T, Yamauchi A, Sakuramoto-Tsuchida S, Mikami S, Yane K, Takasawa S, et al: Expression of REG III and prognosis in head and neck cancer. Oncol Rep. 30:573–578. 2013.PubMed/NCBI | |
Ota H, Tamaki S, Itaya-Hironaka A, Yamauchi A, Sakuramoto-Tsuchida S, Morioka T, Takasawa S and Kimura H: Attenuation of glucose-induced insulin secretion by intermittent hypoxia via down-regulation of CD38. Life Sci. 90:206–211. 2012. View Article : Google Scholar | |
Akiyama T, Takasawa S, Nata K, Kobayashi S, Abe M, Shervani NJ, Ikeda T, Nakagawa K, Unno M, Matsuno S, et al: Activation of Reg gene, a gene for insulin-producing β-cell regeneration: Poly(ADP-ribose) polymerase binds Reg promoter and regulates the transcription by autopoly(ADP-ribosyl)ation. Proc Natl Acad Sci USA. 98:48–53. 2001. | |
Nakagawa K, Takasawa S, Nata K, Yamauchi A, Itaya-Hironaka A, Ota H, Yoshimoto K, Sakuramoto-Tsuchida S, Miyaoka T, Takeda M, et al: Prevention of Reg I-induced β-cell apoptosis by IL-6/dexamethasone through activation of HGF gene regulation. Biochim Biophys Acta. 1833:2988–2995. 2013. View Article : Google Scholar : PubMed/NCBI | |
Yamauchi A, Itaya-Hironaka A, Sakuramoto-Tsuchida S, Takeda M, Yoshimoto K, Miyaoka T, Fujimura T, Tsujinaka H, Tsuchida C, Ota H, et al: Synergistic activations of REG Iα and REG Iβ promoters by IL-6 and glucocorticoids through JAK/STAT pathway in human pancreatic β cells. J Diabetes Res. 2015:1730582015. View Article : Google Scholar | |
Fujimura T, Fujimoto T, Itaya-Hironaka A, Miyaoka T, Yoshimoto K, Yamauchi A, Sakuramoto-Tsuchida S, Kondo S, Takeda M, Tsujinaka H, et al: Interleukin-6/STAT pathway is responsible for the induction of gene expression of REG Iα, a new auto-antigen in Sjögren’s syndrome patients, in salivary duct epithelial cells. Biochem Biophys Rep. 2:69–74. 2015. | |
Tsujinaka H, Itaya-Hironaka A, Yamauchi A, Sakuramoto-Tsuchida S, Ota H, Takeda M, Fujimura T, Takasawa S and Ogata N: Human retinal pigment epithelial cell proliferation by the combined stimulation of hydroquinone and advanced glycation end-products via up-regulation of VEGF gene. Biochem Biophys Rep. 2:123–131. 2015. | |
Takasawa S, Kuroki M, Nata K, Noguchi N, Ikeda T, Yamauchi A, Ota H, Itaya-Hironaka A, Sakuramoto-Tsuchida S, Takahashi I, et al: A novel ryanodine receptor expressed in pancreatic islets by alternative splicing from type 2 ryanodine receptor gene. Biochem Biophys Res Commun. 397:140–145. 2010. View Article : Google Scholar : PubMed/NCBI | |
Ota H, Itaya-Hironaka A, Yamauchi A, Sakuramoto-Tsuchida S, Miyaoka T, Fujimura T, Tsujinaka H, Yoshimoto K, Nakagawara K, Tamaki S, et al: Pancreatic β cell proliferation by intermittent hypoxia via up-regulation of Reg family genes and HGF gene. Life Sci. 93:664–672. 2013. View Article : Google Scholar : PubMed/NCBI | |
Liu XJ, Bao HR, Zeng XL and Wei JM: Effects of resveratrol and genistein on nuclear factor κB, tumor necrosis factor α and matrix metalloproteinase 9 in patients with chronic obstructive pulmonary disease. Mol Med Rep. 13:4266–4272. 2016.PubMed/NCBI | |
Ogawa H, Fukushima K, Naito H, Funayama Y, Unno M, Takahashi K, Kitayama T, Matsuno S, Ohtani H, Takasawa S, et al: Increased expression of HIP/PAP and regenerating gene III in human inflammatory bowel disease and a murine bacterial reconstitution model. Inflamm Bowel Dis. 9:162–170. 2003. View Article : Google Scholar : PubMed/NCBI | |
Vives-Pi M, Takasawa S, Pujol-Autonell I, Planas R, Cabre E, Ojanguren I, Montraveta M, Santos AL and Ruiz-Ortiz E: Biomarkers for diagnosis and monitoring of celiac disease. J Clin Gastroenterol. 47:308–313. 2013. View Article : Google Scholar : PubMed/NCBI | |
Dusetti NJ, Mallo GV, Ortiz EM, Keim V, Dagorn JC and Iovanna JL: Induction of lithostathine/reg mRNA expression by serum from rats with acute pancreatitis and cytokines in pancreatic acinar AR-42J cells. Arch Biochem Biophys. 330:129–132. 1996. View Article : Google Scholar : PubMed/NCBI | |
Kinoshita Y, Ishihara S, Kadowaki Y, Fukui H and Chiba T: Reg protein is a unique growth factor of gastric mucosal cells. J Gastroenterol. 39:507–513. 2004. View Article : Google Scholar : PubMed/NCBI | |
Usami S, Motoyama S, Koyota S, Wang J, Hayashi-Shibuya K, Maruyama K, Takahashi N, Saito H, Minamiya Y, Takasawa S, et al: Regenerating gene I regulates interleukin-6 production in squamous esophageal cancer cells. Biochem Biophys Res Commun. 392:4–8. 2010. View Article : Google Scholar : PubMed/NCBI | |
Yoshino N, Ishihara S, Rumi MA, Ortega-Cava CF, Yuki T, Kazumori H, Takazawa S, Okamoto H, Kadowaki Y and Kinoshita Y: Interleukin-8 regulates expression of Reg protein in Helicobacter pylori-infected gastric mucosa. Am J Gastroenterol. 100:2157–2166. 2005. View Article : Google Scholar : PubMed/NCBI | |
Sekikawa A, Fukui H, Fujii S, Ichikawa K, Tomita S, Imura J, Chiba T and Fujimori T: REG Ialpha protein mediates an anti-apoptotic effect of STAT3 signaling in gastric cancer cells. Carcinogenesis. 29:76–83. 2008. View Article : Google Scholar | |
Yamauchi A, Takahashi I, Takasawa S, Nata K, Noguchi N, Ikeda T, Yoshikawa T, Shervani NJ, Suzuki I, Uruno A, et al: Thiazolidinediones inhibit REG Iα gene transcription in gastrointestinal cancer cells. Biochem Biophys Res Commun. 379:743–748. 2009. View Article : Google Scholar : PubMed/NCBI | |
Cal C, Garban H, Jazirehi A, Yeh C, Mizutani Y and Bonavida B: Resveratrol and cancer: Chemoprevention, apoptosis, and chemo-immunosensitizing activities. Curr Med Chem Anticancer Agents. 3:77–93. 2003. View Article : Google Scholar : PubMed/NCBI | |
Rubiolo JA, López-Alonso H, Martín-Vázquez V, Fol-Rodríguéz NM, Vieytes MR, Botana LM and Vega FV: Resveratrol inhibits proliferation of primary rat hepatocytes in G0/G1 by inhibiting DNA synthesis. Folia Biol (Praha). 58:166–172. 2012. | |
Frémont L: Biological effects of resveratrol. Life Sci. 66:663–673. 2000. View Article : Google Scholar : PubMed/NCBI | |
Kundu JK and Surh YJ: Cancer chemopreventive and therapeutic potential of resveratrol: Mechanistic perspectives. Cancer Lett. 269:243–261. 2008. View Article : Google Scholar : PubMed/NCBI | |
Kovacic P and Somanathan R: Multifaceted approach to resveratrol bioactivity: Focus on antioxidant action, cell signaling and safety. Oxid Med Cell Longev. 3:86–100. 2010. View Article : Google Scholar : PubMed/NCBI | |
Estrov Z, Shishodia S, Faderl S, Harris D, Van Q, Kantarjian HM, Talpaz M and Aggarwal BB: Resveratrol blocks interleukin-1β-induced activation of the nuclear transcription factor NF-kappaB, inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cells. Blood. 102:987–995. 2003. View Article : Google Scholar : PubMed/NCBI | |
Liang YC, Tsai SH, Chen L, Lin-Shiau SY and Lin JK: Resveratrol-induced G2 arrest through the inhibition of CDK7 and p34CDC2 kinases in colon carcinoma HT29 cells. Biochem Pharmacol. 65:1053–1060. 2003. View Article : Google Scholar : PubMed/NCBI | |
ElAttar TM and Virji AS: Modulating effect of resveratrol and quercetin on oral cancer cell growth and proliferation. Anticancer Drugs. 10:187–193. 1999. View Article : Google Scholar : PubMed/NCBI | |
Yeh CB, Hsieh MJ, Lin CW, Chiou HL, Lin PY, Chen TY and Yang SF: The antimetastatic effects of resveratrol on hepatocellular carcinoma through the downregulation of a metastasis-associated protease by SP-1 modulation. PLoS One. 8:e566612013. View Article : Google Scholar : PubMed/NCBI | |
Shankar S, Singh G and Srivastava RK: Chemoprevention by resveratrol: Molecular mechanisms and therapeutic potential. Front Biosci. 12:4839–4854. 2007. View Article : Google Scholar : PubMed/NCBI | |
Hong YB, Kang HJ, Kim HJ, Rosen EM, Dakshanamurthy S, Rondanin R, Baruchello R, Grisolia G, Daniele S and Bae I: Inhibition of cell proliferation by a resveratrol analog in human pancreatic and breast cancer cells. Exp Mol Med. 41:151–160. 2009. View Article : Google Scholar : PubMed/NCBI | |
Liu B, Zhou Z, Zhou W, Liu J, Zhang Q, Xia J, Liu J, Chen N, Li M and Zhu R: Resveratrol inhibits proliferation in human colorectal carcinoma cells by inducing G1/S phase cell cycle arrest and apoptosis through caspase/cyclin CDK pathways. Mol Med Rep. 10:1697–1702. 2014.PubMed/NCBI | |
Wang G, Guo X, Chen H, Lin T, Xu Y, Chen Q, Liu J, Zeng J, Zhang XK and Yao X: A resveratrol analog, phoyunbene B, induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells. Bioorg Med Chem Lett. 22:2114–2118. 2012. View Article : Google Scholar : PubMed/NCBI | |
Bai Y, Mao QQ, Qin J, Zheng XY, Wang YB, Yang K, Shen HF and Xie LP: Resveratrol induces apoptosis and cell cycle arrest of human T24 bladder cancer cells in vitro and inhibits tumor growth in vivo. Cancer Sci. 101:488–493. 2010. View Article : Google Scholar | |
Baribeau S, Chaudhry P, Parent S and Asselin É: Resveratrol inhibits cisplatin-induced epithelial-to-mesenchymal transition in ovarian cancer cell lines. PLoS One. 9:e869872014. View Article : Google Scholar : PubMed/NCBI | |
Lin FY, Hsieh YH, Yang SF, Chen CT, Tang CH, Chou MY, Chuang YT, Lin CW and Chen MK: Resveratrol suppresses TPA-induced matrix metalloproteinase-9 expression through the inhibition of MAPK pathways in oral cancer cells. J Oral Pathol Med. 44:699–706. 2015. View Article : Google Scholar |