PRL-3 improves colorectal cancer cell proliferation and invasion through IL-8 mediated glycolysis metabolism

  • Authors:
    • Heyang Xu
    • Yujie Zeng
    • Lu Liu
    • Qian Gao
    • Shaowen Jin
    • Qiusheng Lan
    • Wei Lai
    • Xingxi Luo
    • Heng Wu
    • Yongliang Huang
    • Zhonghua Chu
  • View Affiliations

  • Published online on: August 2, 2017     https://doi.org/10.3892/ijo.2017.4090
  • Pages: 1271-1279
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Abstract

Phosphatase of regenerating liver-3 (PRL-3) has been found to be overexpressed in liver metastases of colorectal cancer and rarely expressed in primary tumors, which plays an important role in the metastasis of colorectal cancer cells. Metabolism reprogramming has been found to be a hallmark of cancer cells, and aerobic glycolysis is a metabolic adaption for cancer cells and promotes cell proliferation. However, the association between PRL-3 and glycolysis in colorectal cancer cells is not well understood. In the present study, we explored the association between PRL-3 and glycolysis. We found that PRL-3 improved colorectal cancer cell glucose assumption, lactate production and reduced intracellular ROS levels. Besides, PRL-3 improved the expression of Glut1, HK2, PKM2 and LDHA, which are important glycolysis related molecules and enzymes. Moreover, we explored IL-8 mediated enhancement of glycolysis by PRL-3. More importantly, the proliferation and invasion of colorectal cancer cells were enhanced significantly by PRL-3 through improving glycolysis. Taken together, these results implicated the important role of PRL-3 in glycolysis metabolism through improving IL-8 secretion in colorectal cancer cells, and PRL-3 mediated glycolysis contributed to the promotion of cancer metastasis.
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October-2017
Volume 51 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Xu H, Zeng Y, Liu L, Gao Q, Jin S, Lan Q, Lai W, Luo X, Wu H, Huang Y, Huang Y, et al: PRL-3 improves colorectal cancer cell proliferation and invasion through IL-8 mediated glycolysis metabolism. Int J Oncol 51: 1271-1279, 2017
APA
Xu, H., Zeng, Y., Liu, L., Gao, Q., Jin, S., Lan, Q. ... Chu, Z. (2017). PRL-3 improves colorectal cancer cell proliferation and invasion through IL-8 mediated glycolysis metabolism. International Journal of Oncology, 51, 1271-1279. https://doi.org/10.3892/ijo.2017.4090
MLA
Xu, H., Zeng, Y., Liu, L., Gao, Q., Jin, S., Lan, Q., Lai, W., Luo, X., Wu, H., Huang, Y., Chu, Z."PRL-3 improves colorectal cancer cell proliferation and invasion through IL-8 mediated glycolysis metabolism". International Journal of Oncology 51.4 (2017): 1271-1279.
Chicago
Xu, H., Zeng, Y., Liu, L., Gao, Q., Jin, S., Lan, Q., Lai, W., Luo, X., Wu, H., Huang, Y., Chu, Z."PRL-3 improves colorectal cancer cell proliferation and invasion through IL-8 mediated glycolysis metabolism". International Journal of Oncology 51, no. 4 (2017): 1271-1279. https://doi.org/10.3892/ijo.2017.4090