Endoplasmic reticulum stress‑induced cell death as a potential mechanism for targeted therapy in glioblastoma (Review)

  • Authors:
    • Pengfei Shi
    • Zhuohang Zhang
    • Jie Xu
    • Li Zhang
    • Hongjuan Cui
  • View Affiliations

  • Published online on: July 6, 2021     https://doi.org/10.3892/ijo.2021.5240
  • Article Number: 60
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The endoplasmic reticulum (ER) is an essential organelle for protein synthesis, folding and modification, lipid synthesis, and calcium storage. When endogenous or exogenous stimuli lead to ER‑synthesized protein folding dysfunction, numerous unfolded or misfolded proteins accumulate in the ER cavity and cause a series of subsequent responses, referred to as ER stress. If ER stress is continuous, the unfolded protein response (UPR) is not enough to remove the accumulated unfolded and misfolded proteins, and thus, UPR signaling pathways will drive cell apoptosis. Glioblastoma (GBM) is currently the most aggressive and common malignant tumor of the nervous system. Since ER stress may increase the sensitivity of GBM to temozolomide, this article reviews the possible mechanisms of ER stress‑induced apoptosis and the factors affecting ER stress, and evaluates the potential of ER stress as a therapeutic target.
View Figures
View References

Related Articles

Journal Cover

August-2021
Volume 59 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Shi P, Zhang Z, Xu J, Zhang L and Cui H: Endoplasmic reticulum stress‑induced cell death as a potential mechanism for targeted therapy in glioblastoma (Review). Int J Oncol 59: 60, 2021.
APA
Shi, P., Zhang, Z., Xu, J., Zhang, L., & Cui, H. (2021). Endoplasmic reticulum stress‑induced cell death as a potential mechanism for targeted therapy in glioblastoma (Review). International Journal of Oncology, 59, 60. https://doi.org/10.3892/ijo.2021.5240
MLA
Shi, P., Zhang, Z., Xu, J., Zhang, L., Cui, H."Endoplasmic reticulum stress‑induced cell death as a potential mechanism for targeted therapy in glioblastoma (Review)". International Journal of Oncology 59.2 (2021): 60.
Chicago
Shi, P., Zhang, Z., Xu, J., Zhang, L., Cui, H."Endoplasmic reticulum stress‑induced cell death as a potential mechanism for targeted therapy in glioblastoma (Review)". International Journal of Oncology 59, no. 2 (2021): 60. https://doi.org/10.3892/ijo.2021.5240