Open Access

Emerging roles of angiopoietin‑like 4 in human tumors (Review)

  • Authors:
    • Ruyi Liu
    • Miaomiao Fu
    • Pengxiang Chen
    • Yuchen Liu
    • Weicheng Huang
    • Xing Sun
    • Pengfei Zhu
    • Zhihua Wen
    • Yufeng Cheng
  • View Affiliations

  • Published online on: December 19, 2024     https://doi.org/10.3892/ijo.2024.5715
  • Article Number: 9
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Angiopoietin‑like 4 (ANGPTL4), a member of the angiopoietin family, plays critical roles in angiogenesis, lipid metabolism and inflammation. It has been demonstrated that ANGPTL4 has significant influence on various diseases. Accumulating evidence has highlighted the impacts of ANGPTL4 on human malignancies. ANGPTL4 is commonly overexpressed in various types of cancer, such as breast, non‑small cell lung, gastric and colorectal cancer. Its upregulation promotes tumor growth, invasion, metastasis and angiogenesis, as well as metabolic reprogramming and resistance to programmed cell death, radiotherapy and chemotherapy. However, ANGPTL4 has also exhibited antitumor effects under certain conditions, indicating its complex roles in tumor biology. The transcriptional regulation of ANGPTL4 is influenced by multiple factors, such as HIF‑1, PPARs, TGF‑β and long non‑coding RNAs. In terms of signaling pathways, STATs, PI3K/AKT and COX-2/PGE2 are important in regulating cellular processes. The present review summarizes the biological functions of ANGPTL4 in tumors and its association with patient prognosis. Furthermore, the key molecular mechanisms and potential reasons for its dual roles in cancer are also discussed. In conclusion, ANGPTL4 is a valuable diagnostic biomarker and a potential therapeutic target for human cancers.

Related Articles

Journal Cover

February-2025
Volume 66 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Liu R, Fu M, Chen P, Liu Y, Huang W, Sun X, Zhu P, Wen Z and Cheng Y: Emerging roles of angiopoietin‑like 4 in human tumors (Review). Int J Oncol 66: 9, 2025.
APA
Liu, R., Fu, M., Chen, P., Liu, Y., Huang, W., Sun, X. ... Cheng, Y. (2025). Emerging roles of angiopoietin‑like 4 in human tumors (Review). International Journal of Oncology, 66, 9. https://doi.org/10.3892/ijo.2024.5715
MLA
Liu, R., Fu, M., Chen, P., Liu, Y., Huang, W., Sun, X., Zhu, P., Wen, Z., Cheng, Y."Emerging roles of angiopoietin‑like 4 in human tumors (Review)". International Journal of Oncology 66.2 (2025): 9.
Chicago
Liu, R., Fu, M., Chen, P., Liu, Y., Huang, W., Sun, X., Zhu, P., Wen, Z., Cheng, Y."Emerging roles of angiopoietin‑like 4 in human tumors (Review)". International Journal of Oncology 66, no. 2 (2025): 9. https://doi.org/10.3892/ijo.2024.5715