Undifferentiated carcinoma of the gallbladder with endothelial differentiation: A case report and literature review

Furuya,Yoshitaka; Hiroshima,Kenzo; Wakahara,Takashi; Akimoto,Harutoshi; Yanagie,Hironobu; Harigaya,Kenichi; Yasuhara,Hiroshi

doi:10.3892/mco.2016.1046

Undifferentiated carcinoma of the gallbladder with endothelial differentiation: A case report and literature review

Authors:
- Yoshitaka Furuya
- Kenzo Hiroshima
- Takashi Wakahara
- Harutoshi Akimoto
- Hironobu Yanagie
- Kenichi Harigaya
- Hiroshi Yasuhara
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Affiliations: Department of Surgery, Sodegaura Satsukidai Hospital, Chiba 299‑0246, Japan, Department of Pathology, Tokyo Women's Medical University Yachiyo Medical Center, Chiba 276‑8524, Japan, Department of Innovative Cancer Therapeutics, Alpha Particle and Immunotherapeutics, Meiji Pharmaceutical University, Tokyo 204‑8588, Japan, Department of Pathology, Graduate School of Medicine, Chiba University, Chiba 260‑8760, Japan, Surgical Center, University of Tokyo, Tokyo 113‑8655, Japan
Published online on: October 5, 2016 https://doi.org/10.3892/mco.2016.1046
Pages: 773-776

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Abstract

Undifferentiated carcinoma of the gallbladder is a rare cancer type with a poor prognosis. The present study described a case of undifferentiated gallbladder carcinoma of the spindle‑ and giant‑cell type, according to the 2010 World Health Organization classification. Hematoxylin and eosin staining revealed that the tumor consisted of dense interlacing bundles of spindle‑shaped cells. No evidence of cartilaginous, osseous or rhabdomyosarcomatous differentiation was observed. Immunohistochemical staining revealed that spindle‑ and polygonal‑shaped cells of the undifferentiated carcinoma were positive for cytokeratin AE1/3, vimentin and vascular endothelial growth factor. Furthermore, numerous spindle‑shaped cells were positive for cluster of differentiation (CD)34 and CD31, and certain spindle‑shaped cells were positive for Factor VIII. These results suggested classification of the present case as ‘undifferentiated gallbladder carcinoma with endothelial differentiation’.

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