Lipomatous angiomyofibroblastoma of the vulva: A case report and review of the literature

Matsukuma,Susumu; Koga,Ayano; Suematsu,Ryohei; Takeo,Hiroaki; Sato,Kimiya

doi:10.3892/mco.2016.1078

Lipomatous angiomyofibroblastoma of the vulva: A case report and review of the literature

Authors:
- Susumu Matsukuma
- Ayano Koga
- Ryohei Suematsu
- Hiroaki Takeo
- Kimiya Sato
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Affiliations: Department of Pathology, Japan Self-Defense Forces Central Hospital, Tokyo 154-8532, Japan
Published online on: November 10, 2016 https://doi.org/10.3892/mco.2016.1078
Pages: 83-87

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Abstract

Lipomatous angiomyofibroblastoma is extremely rare, with only 16 cases reported to date. We herein describe an additional case arising in the left vulvar region of a 49-year-old woman. The resected 5.3‑cm yellowish tumor predominantly consisted of fat cells (85% of the tumor), together with medium- and small-sized vessels, multifocal fibrotic areas and pseudoangiomatous spaces. Spindle, rounded, and/or epithelioid tumor cells proliferated in a nest and/or cord-like pattern, or singly within perivascular fibrous tissues and between fat cells. The tumor cells were positive for vimentin, estrogen receptor, progesterone receptor, B-cell lymphoma 2, and CD10, but were negative for desmin, cytokeratin, epithelial membrane antigen, S-100 protein, human melanoma black 45, C-kit and p40. Ultrastructural examination revealed that these tumor cells exhibited fibroblastic characteristics. Lipomatous angiomyofibroblastoma should be discriminated from other lipomatous tumors, including spindle cell lipoma, angiomyolipoma and cellular angiofibroma containing numerous fat cells.

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1	Fletcher CDM, Bridge JA, Hogendoorn PCW and Mertens F: WHO classification of tumours of soft tissue and bone. 4th. International Agency for Research on Cancer; Lyon: 2013
2	Goldblum JR, Folpe AL and Weiss SW: Enzinger and Weiss's soft tissue tumors. 6th. Elsevier/Saunders; Philadelphia, PA: 2014
3	Fletcher CDM, Tsang WYW, Fisher C, Lee KC and Chan JKC: Angiomyofibroblastoma of the vulva. A benign neoplasm distinct from aggressive angiomyxoma. Am J Surg Pathol. 16:373–382. 1992. View Article : Google Scholar : PubMed/NCBI
4	Hisaoka M, Kouho H, Aoki T, Daimaru Y and Hashimoto H: Angiomyofibroblastoma of the vulva: A clinicopathologic study of seven cases. Pathol Int. 45:487–492. 1995. View Article : Google Scholar : PubMed/NCBI
5	Nielsen GP, Rosenberg AE, Young RH, Dickersin GR, Clement PB and Scully RE: Angiomyofibroblastoma of the vulva and vagina. Mod Pathol. 9:284–291. 1996.PubMed/NCBI
6	Laskin WB, Fetsch JF and Tavassoli FA: Angiomyofibroblastoma of the female genital tract: Analysis of 17 cases including a lipomatous variant. Hum Pathol. 28:1046–1055. 1997. View Article : Google Scholar : PubMed/NCBI
7	Magro G, Righi A, Caltabiano R, Casorzo L and Michal M: Vulvovaginal angiomyofibroblastomas: Morphologic, immunohistochemical, and fluorescence in situ hybridization analysis for deletion of 13q14 region. Hum Pathol. 45:1647–1655. 2014. View Article : Google Scholar : PubMed/NCBI
8	Hiruki T, Thomas MJ and Clement PB: Vulvar angiomyofibroblastoma. Am J Surg Pathol. 17:423–424. 1993. View Article : Google Scholar : PubMed/NCBI
9	Shintaku M, Naitou M and Nakashima Y: Angiomyofibroblastoma-like tumor (lipomatous variant) of the inguinal region of a male patient. Pathol Int. 52:619–622. 2002. View Article : Google Scholar : PubMed/NCBI
10	Cao D, Srodon M, Montgomery EA and Kurman RJ: Lipomatous variant of angiomyofibroblastoma: Report of two cases and review of the literature. Int J Gynecol Pathol. 24:196–200. 2005. View Article : Google Scholar : PubMed/NCBI
11	Lee SJ, Chung YJ, Lee SH, Choi YJ, Kim N, Son HJ and Yoon JH: Lipomatous variant of angiomyofibroblastoma on the vulva: A case report. Korean J Obstet Gynecol. 53:851–855. 2010. View Article : Google Scholar
12	Vora S, Gaba ND and Stamatakos MD: Lipomatous angiomyofibroblastoma: A case report of a unique vulvar mass. J Reprod Med. 56:347–350. 2011.PubMed/NCBI
13	Magro G, Salvatorelli L, Angelico G, Vecchio GM and Caltabiano R: Lipomatous angiomyofibroblastoma of the vulva: Diagnostic and histogenetic considerations. Pathologica. 106:322–326. 2014.PubMed/NCBI
14	Upreti S, Morine A, Ng D and Bigby SM: Lipomatous variant of angiomyofibroblastoma: A case report and review of the literature. J Cutan Pathol. 42:222–226. 2015. View Article : Google Scholar : PubMed/NCBI
15	Luis PP, Quiñonez E, Nogales FF and McCluggage WG: Lipomatous variant of angiomyofibroblastoma involving the vulva: Report of 3 cases of an extremely rare neoplasm with discussion of the differential diagnosis. Int J Gynecol Pathol. 34:204–207. 2015. View Article : Google Scholar : PubMed/NCBI
16	Nielsen GP, Young RH, Dickersin GR and Rosenberg AE: Angiomyofibroblastoma of the vulva with sarcomatous transformation (“angiomyofibrosarcoma”). Am J Surg Pathol. 21:1104–1108. 1997. View Article : Google Scholar : PubMed/NCBI
17	Reis-Filho JS, Milanezi F, Soares MF, Fillus-Neto J and Schmitt FC: Intradermal spindle cell/pleomorphic lipoma of the vulva: Case report and review of the literature. J Cutan Pathol. 29:59–62. 2002. View Article : Google Scholar : PubMed/NCBI
18	Laskin WB, Fetsch JF and Mostofi FK: Angiomyofibroblastomalike tumor of the male genital tract: Analysis of 11 cases with comparison to female angiomyofibroblastoma and spindle cell lipoma. Am J Surg Pathol. 22:6–16. 1998. View Article : Google Scholar : PubMed/NCBI
19	Iwasa Y and Fletcher CDM: Cellular angiofibroma: Clinicopathologic and immunohistochemical analysis of 51 cases. Am J Surg Pathol. 28:1426–1435. 2004. View Article : Google Scholar : PubMed/NCBI
20	Flucke U, van Krieken JH and Mentzel T: Cellular angiofibroma: Analysis of 25 cases emphasizing its relationship to spindle cell lipoma and mammary-type myofibroblastoma. Mod Pathol. 24:82–89. 2011. View Article : Google Scholar : PubMed/NCBI