Open Access

Successful treatment of lung cancer coexisting with B‑cell lymphoma with pembrolizumab following rituximab‑included chemotherapy: A case report

  • Authors:
    • Daisuke Natori
    • Hiroaki Ozasa
    • Yusuke Shima
    • Chisaki Mizumoto
    • Keiichiro Suminaga
    • Takashi Nomizo
    • Hitomi Ajimizu
    • Hironori Yoshida
    • Toyohiro Hirai
  • View Affiliations

  • Published online on: February 23, 2024     https://doi.org/10.3892/mco.2024.2731
  • Article Number: 33
  • Copyright: © Natori et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The combined occurrence of lung cancer and B‑cell lymphoma, such as mucosa‑associated lymphoid tissue (MALT) lymphoma, is rare. The efficacy and safety of immune checkpoint inhibitors (ICIs) remain unknown in this population of patients, and the occurrence of ICI‑induced exacerbation of lymphoma is concerning. The present study describes a case of successful treatment with pembrolizumab following rituximab‑containing chemotherapy for lung cancer complicated by MALT lymphoma. The patient was a 69‑year‑old woman diagnosed with MALT lymphoma based on a biopsy of stomach ulcerative lesions, and advanced lung cancer based on a biopsy of a lymph node in the left pulmonary hilum. Complete remission was achieved after one cycle of rituximab and bendamustine therapy for MALT lymphoma. Pembrolizumab monotherapy was subsequently initiated, resulting in a good response for lung cancer without recurrence or exacerbation of the lymphoma. In conclusion, the present study suggested that pembrolizumab, following rituximab‑containing therapy, could be a treatment option for patients with lung cancer coexisting with MALT lymphoma.
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April-2024
Volume 20 Issue 4

Print ISSN: 2049-9450
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Spandidos Publications style
Natori D, Ozasa H, Shima Y, Mizumoto C, Suminaga K, Nomizo T, Ajimizu H, Yoshida H and Hirai T: Successful treatment of lung cancer coexisting with B‑cell lymphoma with pembrolizumab following rituximab‑included chemotherapy: A case report. Mol Clin Oncol 20: 33, 2024.
APA
Natori, D., Ozasa, H., Shima, Y., Mizumoto, C., Suminaga, K., Nomizo, T. ... Hirai, T. (2024). Successful treatment of lung cancer coexisting with B‑cell lymphoma with pembrolizumab following rituximab‑included chemotherapy: A case report. Molecular and Clinical Oncology, 20, 33. https://doi.org/10.3892/mco.2024.2731
MLA
Natori, D., Ozasa, H., Shima, Y., Mizumoto, C., Suminaga, K., Nomizo, T., Ajimizu, H., Yoshida, H., Hirai, T."Successful treatment of lung cancer coexisting with B‑cell lymphoma with pembrolizumab following rituximab‑included chemotherapy: A case report". Molecular and Clinical Oncology 20.4 (2024): 33.
Chicago
Natori, D., Ozasa, H., Shima, Y., Mizumoto, C., Suminaga, K., Nomizo, T., Ajimizu, H., Yoshida, H., Hirai, T."Successful treatment of lung cancer coexisting with B‑cell lymphoma with pembrolizumab following rituximab‑included chemotherapy: A case report". Molecular and Clinical Oncology 20, no. 4 (2024): 33. https://doi.org/10.3892/mco.2024.2731