Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015.PubMed/NCBI View Article : Google Scholar

Leus AJG, Haisma MS, Terra JB, Diercks GFH, Van Kester MS, Halmos GB, Rácz E, Van Dijk BAC and Plaat BEC: Age-related differences in tumour characteristics and prognostic factors for disease progression in cutaneous squamous cell carcinoma of the head and neck. Acta Derm Venereol. 102(adv00652)2022.PubMed/NCBI View Article : Google Scholar

Grover P, Flukes S, Jacques A, Leedman S, Lindsay A, White R, Friedland P, Gurfinkel R and Lim AM: Clinicopathological characteristics and clinical morbidity in high-risk head and neck cutaneous squamous cell carcinoma patients in Western Australia. Intern Med J. 52:944–951. 2022.PubMed/NCBI View Article : Google Scholar

Han AY and John MAS: Predictors of nodal metastasis in cutaneous head and neck cancers. Curr Oncol Rep. 24:1145–1152. 2022.PubMed/NCBI View Article : Google Scholar

Grammatica A, Tomasoni M, Fior M, Ulaj E, Gualtieri T, Bossi P, Battocchio S, Lombardi D, Deganello A, Mattavelli D, et al: Regional disease in head and neck cutaneous squamous cell carcinoma: The role of primary tumor characteristics and number of nodal metastases. Eur Arch Otorhinolaryngol. 279:1573–1584. 2022.PubMed/NCBI View Article : Google Scholar

Lubov J, Labbé M, Sioufi K, Morand GB, Hier MP, Khanna M, Sultanem K and Mlynarek AM: Prognostic factors of head and neck cutaneous squamous cell carcinoma: A systematic review. J Otolaryngol Head Neck Surg. 50(54)2021.PubMed/NCBI View Article : Google Scholar

Fox M, Brown M, Golda N, Goldberg D, Miller C, Pugliano-Mauro M, Schmults C, Shin T, Stasko T, Xu YG, et al: Nodal staging of high-risk cutaneous squamous cell carcinoma. J Am Acad Dermatol. 81:548–557. 2019.PubMed/NCBI View Article : Google Scholar

Arron ST, Wysong A, Hall MA, Bailey CN, Covington KR, Kurley SJ, Goldberg MS, Kasprzak JM, Somani AK, Ibrahim SF, et al: Gene expression profiling for metastatic risk in head and neck cutaneous squamous cell carcinoma. Laryngoscope Investig Otolaryngol. 7:135–144. 2022.PubMed/NCBI View Article : Google Scholar

Hurell MJL, Low TH, Ebranhimi A, Veness M, Ashford B, Porceddu S and Clark JR: Evolution of head and neck cutaneous squamous cell carcinoma nodal staging-an Australian perspective. Cancers (Basel). 14(5101)2022.PubMed/NCBI View Article : Google Scholar

Stewart JR, Ahn JW and Brewer JD: In-transit metastasis of cutaneous squamous cell carcinoma with lymphovascular invasion in an immunocompetent patient. Cureus. 14(e21204)2022.PubMed/NCBI View Article : Google Scholar

Morosin T, Ashford B, Ranson M, Gupta R, Clark J, Iyer NG and Spring K: Circulating tumour cells in regionally metastatic cutaneous squamous cell carcinoma: A pilot study. Oncotarget. 7:47111–47115. 2016.PubMed/NCBI View Article : Google Scholar

Nwabudike LC and Tatu AL: Reply to Gambichler T et al: Altered epigenetic pathways and cell cycle dysregulation in healthy appearing skin of patients with koebnerized squamous cell carcinomas following skin surgery. J Eur Acad Dermatol Venereol. 33:e3–e4. 2019.

Janković I, Kovačević P, Janković D, Stevanović G and Momčilović S: Lymphatic drainage map of the head and neck skin squamous cell carcinoma detected by sentinel lymph node biopsy. Eur Rev Med Pharmacol Sci. 25:5228–5234. 2021.PubMed/NCBI View Article : Google Scholar

Waldman A and Schmults C: Cutaneous squamous cell carcinoma. Hematol Oncol Clin North Am. 33:1–12. 2019.PubMed/NCBI View Article : Google Scholar

Thiem DGE, Scharr K, Pabst AM, Saka B and Kämmerer PW: Facial cutaneous squamous cell carcinoma-microscopic safety margins and their impact on developing local recurrences. J Craniomaxillofac Surg. 48:49–55. 2020.PubMed/NCBI View Article : Google Scholar

Hori R, Shinohara S, Kojima T, Kogoshima H, Kitamura M, Tateya I, Tamaki H, Kumabe Y, Asato R, Harada H, et al: Real world outcomes and prognostic factors in patients receiving Nivolumab therapy for reccurent or metastatic head and neck carcinoma. Cancers (Basel). 11(1317)2019.PubMed/NCBI View Article : Google Scholar

Wu MP, Sethi RKV and Emerick KS: Sentinel lymph node biopsy for high-risk cutaneous squamous cell carcinoma of the head and neck. Laryngoscope. 130:108–114. 2020.PubMed/NCBI View Article : Google Scholar

Hughes BGM, Munoz-Couselo E, Mortier L, Bratland Å, Gutzmer R, Roshdy O, González Mendoza R, Schachter J, Arance A, Grange F, et al: Pembrolizumab for locally advanced and recurrent/metastatic cutaneous squamous cell carcinoma (KEYNOTE-629 study): An open-label, nonrandomized, multicenter, phase II trial. Ann Oncol. 32:1276–1285. 2021.PubMed/NCBI View Article : Google Scholar

Baggi A, Quaglino P, Rubatto M, Depenni R, Guida M, Ascierto PA, Trojaniello C, Queirolo P, Saponara M, Peris K, et al: Real world data of cemiplimab in locally advanced and metastatic cutaneous squamous cell carcinoma. Eur J Cancer. 157:250–258. 2021.PubMed/NCBI View Article : Google Scholar

Mei Z, Huang J, Qiao B and Lam AK: Immune checkpoint pathways in immunotherapy for head and neck squamous cell carcinoma. Int J Oral Sci. 12(16)2020.PubMed/NCBI View Article : Google Scholar

Constantino A, Canali L, Festa BM, Spriano G, Mercante G and De Virgilio A: Sentinel lymph node biopsy in high-risk cutaneous squamous cell carcinoma of the head and neck: Systematic review and meta-analysis. Head Neck. 44:2288–2300. 2022.PubMed/NCBI View Article : Google Scholar

Labani-Motlagh A, Ashja-Mahdavi M and Loskog A: The tumor microenvironment: A milieu hindering and obstructing antitumor immune responses. Front Immunol. 11(940)2020.PubMed/NCBI View Article : Google Scholar

Chen A, Ali N, Boasberg P and Ho AS: Clinical remission of cutaneous squamous cell carcinoma of the auricle with cetuximab and nivolumab. J Clin Med. 7(10)2018.PubMed/NCBI View Article : Google Scholar

Thornton AM, Piccirillo CA and Shevach EM: Activation requirements for the induction of CD4+CD25+ T cell suppressor function. Eur J Immunol. 34:366–76. 2004.PubMed/NCBI View Article : Google Scholar

Harrell CR, Simovic Markovic B, Fellabaum C, Arsenijevic A, Djonov V and Volarevic V: Molecular mechanisms underlying therapeutic potential of pericytes. J Biomed Sci. 25(21)2018.PubMed/NCBI View Article : Google Scholar

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2019. CA Cancer J Clin. 69:7–34. 2019.PubMed/NCBI View Article : Google Scholar

Coughlin SS and Dean LT: Cancer survivorship care plans, financial toxicity, and financial planning alleviating financial distress among cancer survivors. Support Care Cancer. 27:1969–1971. 2019.PubMed/NCBI View Article : Google Scholar

Ezzedine K, Painchault C and Brignone M: Use of complete clearance for assessing treatment efficacy for 5-fluorouracil interventions in actinic keratoses: How baseline lesion count can impact this outcome. J Mark Access Health Policy. 8(1829884)2020.PubMed/NCBI View Article : Google Scholar

Bortoluzzi P, Brambilla R, Berti E, Marzano AV and Piccinno R: The role of radiotherapy in the management of cutaneous squamous cell carcinoma: A retrospective study on 92 cases. Ital Dermatol Venereol. 157:363–367. 2022.PubMed/NCBI View Article : Google Scholar

McDowell L and Yom S: Locally advanced non-melanomatous skin cancer: Contemporary radiotherapeutic management. Oral Oncol. 99(104443)2019.PubMed/NCBI View Article : Google Scholar

Hazim AZ, Reed CT, Price KA, Foote RL, Ma DJ, Neben-Wittich M, DeLone DR, Jenkins SM, Smith CY and Chintakuntlawar AV: Survival outcomes in locally advanced cutaneous squamous cell carcinoma presenting with clinical perineural invasion alone. Head Neck. 43:1995–2001. 2021.PubMed/NCBI View Article : Google Scholar

Schachtel MJC, Gandhi M, Bowman JJ, Porceddu SV and Panizza BJ: Facial nerve perineural spread from cutaneous squamous cell carcinoma of the head and neck: A single institution analysis of epidemiology, treatment, survival outcomes, and prognostic factors. Head Neck. 44:1223–1236. 2022.PubMed/NCBI View Article : Google Scholar

Jackson JE, Dickie GJ, Wiltshire KL, Keller J, Tripcony L, Poulsen MG, Hughes M, Allison RW and Martin JM: Radiotherapy for perineural invasion in cutaneous head and neck carcinomas: Toward a risk-adapted treatment approach. Head Neck. 31:604–610. 2009.PubMed/NCBI View Article : Google Scholar

Amit M, Liu C, Mansour J, Gleber-Netto FO, Tam S, Baruch EN, Aashiq M, El-Naggar AK, Moreno AC, Rosenthal DI, et al: Elective neck dissection versus observation in patients with head and neck cutaneous squamous cell carcinoma. Cancer. 127:4413–4420. 2021.PubMed/NCBI View Article : Google Scholar

Lin C, Ballah T, Nottage M, Hay K, Chua B, Kenny L, Thomas P, Teng M, Keller J, Le T, et al: A prospective study investigating the efficacy and toxicity of definitive ChemoRadiation and ImmunOtherapy (CRIO) in locally and/or regionally advanced unresectable cutaneous squamous cell carcinoma. Radiat Oncol. 16(69)2021.PubMed/NCBI View Article : Google Scholar

Dikova V, Jantus-Lewintre E and Bagan J: Potential non-invasive biomarkers for early diagnosis of oral squamous cell carcinoma. J Clin Med. 10(1658)2021.PubMed/NCBI View Article : Google Scholar

Villa A, Celentano A, Glurich I, Borgnakke WS, Jensen SB, Peterson DE, Delli K, Ojeda D, Vissink A and Farah CS: World workshop on oral medicine VII: Prognostic biomarkers in oral leukoplakia: A systematic review of longitudinal studies. Oral Dis. 25 (Suppl 1):S64–S78. 2019.PubMed/NCBI View Article : Google Scholar

Assao A, Domingues MAC, Minicucci EM, Marchi FA, Coutinho-Camillo CM and Oliveira DT: The relevance of miRNAs as promising biomarkers in lip cancer. Clin Oral Investig. 25:4591–4598. 2021.PubMed/NCBI View Article : Google Scholar

Panarese I, Aquino G, Ronchi A, Longo F, Montella M, Cozzolino I, Roccuzzo G, Colella G, Caraglia M and Franco R: Oral and Oropharyngeal squamous cell carcinoma: Prognostic and predictive parameters in the etiopathogenetic route. Expert Rev Anticancer Ther. 19:105–119. 2019.PubMed/NCBI View Article : Google Scholar

Wilkat M, Bast H, Drees R, Dünser J, Mahr A, Azoitei N, Marienfeld R, Frank F, Brhel M, Ushmorov A, et al: Adenosine receptor 2B activity promotes autonomous growth, migration as well as vascularization of head and neck squamous cell carcinoma cells. Int J Cancer. 147:202–217. 2020.PubMed/NCBI View Article : Google Scholar

Liu SC, Wu YC, Huang CM, Hsieh MS, Huang TY, Huang CS, Hsu TN, Huang MS, Lee WH, Yeh CT and Lin CS: Inhibition of Bruton's tyrosine kinase as a therapeutic strategy for chemoresistant oral squamous cell carcinoma and potential suppression of cancer stemness. Oncogenesis. 10(20)2021.PubMed/NCBI View Article : Google Scholar

Alsahafi E, Begg K, Amelio I, Raulf N, Lucarelli P, Sauter T and Tavassoli M: Clinical update on head and neck cancer: Molecular biology and ongoing challenges. Cell Death Dis. 10(540)2019.PubMed/NCBI View Article : Google Scholar

Grassilli E, Cerrito MG, Bonomo S, Giovannoni R, Conconi D and Lavitrano M: p65BTK is a novel biomarker and therapeutic target in solid tumors. Front Cell Dev Biol. 9(690365)2021.PubMed/NCBI View Article : Google Scholar

Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE and Grandis JR: Head and neck squamous cell carcinoma. Nat Rev Dis Primers. 6(92)2020.PubMed/NCBI View Article : Google Scholar

Ngan HL, Liu Y, Fong AY, Poon PHY, Yeung CK, Chan SSM, Lau A, Piao W, Li H, Tse JSW, et al: MAPK pathway mutations in head and neck cancer affect immune microenvironments and ErbB3 signaling. Life Sci Alliance. 3(e201900545)2020.PubMed/NCBI View Article : Google Scholar

Wilbur J: Surveillance of the adult cancer survivor. Am Fam Physician. 91:29–36. 2015.PubMed/NCBI

Kriegs M, Clauditz TS, Hoffer K, Bartels J, Buhs S, Gerull H, Zech HB, Bußmann L, Struve N, Rieckmann T, et al: Analyzing expression and phosphorylation of the EGF receptor in HNSCC. Sci Rep. 9(13564)2019.PubMed/NCBI View Article : Google Scholar

Lee A, Duggan S and Deeks ED: Cemiplimab: A review in advanced cutaneous squamous cell carcinoma. Drugs. 80:813–819. 2020.PubMed/NCBI View Article : Google Scholar

Ilmonen S, Sollamo E, Juteau S and Koljonen V: Sentinel lymph node biopsy in high-risk cutaneous squamous cell carcinoma of the head and neck. J Plast Reconstr Aesthet Surg. 75:210–216. 2022.PubMed/NCBI View Article : Google Scholar

Maubec E, Boubaya M, Petrow P, Beylot-Barry M, Basset-Seguin N, Deschamps L, Grob JJ, Dréno B, Scheer-Senyarich I, Bloch-Queyrat C, et al: Phase II study of pembrolizumab as first-line, single-drug therapy for patients with unresectable cutaneous squamous cell carcinomas. J Clin Oncol. 38:3051–3061. 2020.PubMed/NCBI View Article : Google Scholar

Luk PP, Ebrahimi A, Veness MJ, McDowell L, Magarey M, Gao K, Palme CE, Clark JR and Gupta R: Prognostic value of the 8th edition American joint commission cancer nodal staging system for patients with head and neck cutaneous squamous cell carcinoma: A multi-institutional study. Head Neck. 43:558–567. 2021.PubMed/NCBI View Article : Google Scholar

Schmidt C, Martin JM, Khoo E, Plank A and Grigg R: Outcomes of nodal metastatic cutaneous squamous cell carcinoma of the head and neck treated in a regional center. Head Neck. 37:1808–1815. 2015.PubMed/NCBI View Article : Google Scholar

Hahlweg P, Hoffmann J, Härter M, Frosch DL, Elwyn G and Scholl I: In absentia: An exploratory study of how patients are considered in multidisciplinary cancer team meetings. PLoS One. 10(e0139921)2015.PubMed/NCBI View Article : Google Scholar

Robinson TE, Janssen A, Harnett P, Museth KE, Provan PJ, Hills DJ and Shaw T: Embedding continuous quality improvement processes in multidisciplinary teams in cancer care: Exploring the boundaries between quality and implementation science. Aust Health Rev. 41:291–296. 2017.PubMed/NCBI View Article : Google Scholar

Hoesseini A, Dronkers EAC, Sewnaik A, Hardillo JAU, Baatenburg de Jong RJ and Offerman MPJ: Head and neck cancer patients' preferences for individualized prognostic information: A focus group study. BMC Cancer. 20(399)2020.PubMed/NCBI View Article : Google Scholar

Szturz P and Vermorken JB: Management of recurrent and metastatic oral cavity cancer: Raising the bar a step higher. Oral Oncol. 101(104492)2020.PubMed/NCBI View Article : Google Scholar

Bruni D, Angell HK and Galon J: The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy. Nat Rev Cancer. 20:662–680. 2020.PubMed/NCBI View Article : Google Scholar

Ziemann F, Arenz A, Preising S, Wittekindt C, Klussmann JP, Engenhart-Cabillic R and Wittig A: Increased sensitivity of HPV-positive head and neck cancer cell lines to x-irradiation ± cisplatin due to decreased expression of E6 and E7 oncoproteins and enhanced apoptosis. Am J Cancer Res. 5:1017–1031. 2015.PubMed/NCBI

Chen YP, Wang YQ, Lv JW, Li YQ, Chua MLK, Le QT, Lee N, Colevas AD, Seiwert T, Hayes DN, et al: Identification and validation of novel microenvironment-based immune molecular subgroups of head and neck squamous cell carcinoma: Implications for immunotherapy. Ann Oncol. 31:316–318. 2018.PubMed/NCBI View Article : Google Scholar

Ji H and Zhou Z: A ‘Hybrid’ radiotherapy regimen designed for immunomodulation: Combining high-dose radiotherapy with low-dose radiotherapy. Cancers (Basel). 14(3505)2022.PubMed/NCBI View Article : Google Scholar

Patil VM, Singh GK, Noronha V, Joshi A, Menon N, Lashkar SG, Mathrudev V, Satam KN, Mukadam SA and Prabhash K: Lymphopenia during chemoradiation-Foe or friend. Ecancermedicalscience. 14(1109)2020.PubMed/NCBI View Article : Google Scholar

Köcher S, Zech HB, Krug L, Gatzemeier F, Christiansen S, Meyer F, Rietow R, Struve N, Mansour WY, Kriegs M, et al: A lack of effectiveness in the ATM-orchestrated DNA damage response contributes to the DNA repair defect of hpv-positive head and neck cancer cells. Front Oncol. 12(765968)2022.PubMed/NCBI View Article : Google Scholar

Brancaccio G, Briatico G, Pellegrini C, Rocco T, Moscarella E and Fargnoli MC: Risk factors and diagnosis of advanced cutaneous squamous cell carcinoma. Dermatol Pract Concept. 11 (Suppl 2)(e2021166S)2021.PubMed/NCBI View Article : Google Scholar

Skulsky SL, O'Sullivan B, McArdle O, Leader M, Roche M, Conlon PJ and O'Neill JP: Review of high-risk features of cutaneous squamous cell carcinoma and discrepancies between the American joint committee on cancer and NCCN clinical practice guidelines in oncology. Head Neck. 39:578–594. 2017.PubMed/NCBI View Article : Google Scholar

Chen SY, Chen QW, Shou LM, Pan H, Ruan SM, Liang ZH and Shu QJ: Stevens-Johnson syndrome/toxic epidermal necrolysis successfully treated with Chinese herbal medicine Pi-Yan-Ning: A case report. J Integr Med. 19:555–560. 2021.PubMed/NCBI View Article : Google Scholar

Liu Y, Tang J, Yu LY and Jiang Q: Successful treatment of immune-related lichenoid dermatitis by Weiling decoction in a patient with non-small cell lung cancer: A case report and review of literature. Explore (NY). 19:730–735. 2023.PubMed/NCBI View Article : Google Scholar

Luo B, Que ZJ, Zhou ZY, Wang Q, Dong CS, Jiang Y, Hu B, Shi H, Jin Y, Liu JW, et al: Feiji Recipe inhibits the growth of lung cancer by modulating T-cell immunity through indoleamine-2,3-dioxygenase pathway in an orthotopic implantation model. J Integr Med. 16:283–289. 2018.PubMed/NCBI View Article : Google Scholar

Flezar MS, Prevodnik VK, Kirbis IS and Strojan P: Cutaneous squamous cell carcinoma metastatic to chronic lymphocytic leukaemia: Diagnostic potential of fine needle aspiration cytology. Cytopathology. 17:288–294. 2006.PubMed/NCBI View Article : Google Scholar

Künzel J, Brandenstein M, Zeman F, Symeou L, Platz Batista da Silva N and Jung EM: Multiparametric ultrasound of cervical lymph node metastases in head and neck cancer for planning non-surgical therapy. Diagnostics (Basel). 12(1842)2022.PubMed/NCBI View Article : Google Scholar

Rossi SH, Prezzi D, Kelly-Morland C and Goh V: Imaging for the diagnosis and response assessment of renal tumours. World J Urol. 36:1927–1942. 2018.PubMed/NCBI View Article : Google Scholar

Machiels JP, Rene Leemans C, Golusinski W, Grau C, Licitra L and Gregoire V: EHNS Executive Board. Electronic address: simplesecretariat@ehns.org, ESMO Guidelines Committee. Electronic address: simpleclinicalguidelines@esmo.org, ESTRO Executive Board. Electronic address: simpleinfo@estro.org. Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS-ESMO-ESTRO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 31:1462–1475. 2020.PubMed/NCBI View Article : Google Scholar

Vos JL, Elbers JBW, Krijgsman O, Traets JJH, Qiao X, van der Leun AM, Lubeck Y, Seignette IM, Smit LA, Willems SM, et al: Neoadjuvant immunotherapy with nivolumab and ipilimumab induces major pathological responses in patients with head and neck squamous cell carcinoma. Nat Commun. 12(7348)2021.PubMed/NCBI View Article : Google Scholar

Khadela A, Shah Y, Mistry P, Bodiwala K and Cb A: Immunomodulatory therapy in head and neck squamous cell carcinoma: Recent advances and clinical prospects. Technol Cancer Res Treat. 22(15330338221150559)2023.PubMed/NCBI View Article : Google Scholar

Petit C, Lacas B, Pignon JP, Le QT, Grégoiere V, Grau C, Hackshaw A, Zackrisson B, Parmar MKB, Lee JW, et al: Chemotherapy and radiotherapy in locally advanced head and neck cancer: An individual patient data network meta-analysis. Lancet Oncol. 22:727–736. 2021.PubMed/NCBI View Article : Google Scholar

Newman JG, Hall MA, Kurley SJ, Cook RW, Farberg AS, Geiger JL and Koyfman SA: Adjuvant therapy for high-risk cutaneous squamous cell carcinoma: 10-Year review. Head Neck. 43:2822–2843. 2021.PubMed/NCBI View Article : Google Scholar

Svajdova M, Dubinsky P and Kazda T: Radical external beam re-irradiation in the treatment of recurrent head and neck cancer: Critical review. Head Neck. 43:354–366. 2021.PubMed/NCBI View Article : Google Scholar

Uppaluri R, Campbell KM, Egloff AM, Zolkind P, Skidmore ZL, Nussenbaum B, Paniello RC, Rich JT, Jackson R, Pipkorn P, et al: Neoadjuvant and adjuvant pembrolizumab in resectable locally advanced, human papillomavirus-unrelated head and neck cancer: A multicenter, phase II trial. Clin Cancer Res. 26:5140–5152. 2020.PubMed/NCBI View Article : Google Scholar

Ng SP, Pollard C III, Kamal M, Ayoub Z, Garden AS, Bahig H, Gunn GB, Frank SJ, Skinner HD, Phan J, et al: Risk of second primary malignancies in head and neck cancer patients treated with definitive radiotherapy. NPJ Precis Oncol. 3(22)2019.PubMed/NCBI View Article : Google Scholar

Lideståhl A, Johansson G, Siegbahn A and Lind PA: Estimated risk of radiation-induced cancer after thymoma treatments with proton- or X-ray beams. Cancers (Basel). 13(5153)2021.PubMed/NCBI View Article : Google Scholar

Ordoñez R, Otero A, Jerez I, Medina JA, Lupiañez-Pérez Y and Gomez-Millan J: Role of radiotherapy in the treatment of metastatic head and neck cancer. Onco Targets Ther. 12:677–683. 2019.PubMed/NCBI View Article : Google Scholar

Zhang S, Zeng N, Yang J, He J, Zhu F, Liao W, Xiong M and Li Y: Advancements of radiotherapy for recurrent head and neck cancer in modern era. Radiat Oncol. 18(166)2023.PubMed/NCBI View Article : Google Scholar

Runnels J, Bloom JR, Hsieh K, Dickstein DR, Shi Y, Jones BM, Lehrer EJ and Bakst RL: Combining radiotherapy and immunotherapy in head and neck cancer. Biomedicines. 11(2097)2023.PubMed/NCBI View Article : Google Scholar

Fang LC, Lemos B, Douglas J, Iyer J and Nghiem P: Radiation monotherapy as regional treatment for lymph node-positive Merkel cell carcinoma. Cancer. 116:1783–1790. 2010.PubMed/NCBI View Article : Google Scholar

Wahlberg P, Anderson H, Biörklund A, Möller T and Perfekt R: Carcinoma of the parotid and submandibular glands-a study of survival in 2465 patients. Oral Oncol. 38:706–713. 2002.PubMed/NCBI View Article : Google Scholar

Reichelmann H, Dejaco D, Steinbichler TB, Lettenbich-Haug A, Anegg M, Ganswindt U, Gamerith G and Riedl D: Functional outcomes in head and neck cancer patients. Cancers (Basel). 14(2135)2022.PubMed/NCBI View Article : Google Scholar

Henry M, Harvey R, Chen LM, Meaney M, Nguyen TTT, Kao HT, Rosberger Z, Frenkiel S, Hier M, Zeitouni A, et al: Genetic predisposition to depression and inflammation impacts symptom burden and survival in patients with head and neck cancer: A longitudinal study. J Affect Disord. 331:149–157. 2023.PubMed/NCBI View Article : Google Scholar

Ch'ng S, Low I, Ng D, Brasch H, Sullivan M, Davis P and Tan ST: Epidermal growth factor receptor: A novel biomarker for aggressive head and neck cutaneous squamous cell carcinoma. Hum Pathol. 39:344–349. 2008.PubMed/NCBI View Article : Google Scholar

Bachar G, Mizrachi A, Rabinovics N, Guttman D, Shpitzer T, Ad-El D and Hadar T: Prognostic factors in metastatic cutaneous squamous cell carcinoma of the head and neck. Ear Nose Throat J. 95:E32–E36. 2016.PubMed/NCBI

Sood A, Wykes J, Roshan D, Wang LY, McGuinness J, Fowler A and Ebrahimi A: A critical analysis of the prognostic performance of the 8th edition American joint committee on cancer staging for metastatic cutaneous squamous cell carcinoma of the head and neck. Head Neck. 41:1591–1596. 2019.PubMed/NCBI View Article : Google Scholar

Bossi P, Alfieri S, Strojan P, Takes RP, López F, Mäkitie A, Saba NF, Rodrigo JP, Bradford C, Suarez C, et al: Prognostic and predictive factors in recurrent and/or metastatic head and neck squamous cell carcinoma: A review of the literature. Crit Rev Oncol Hematol. 137:84–91. 2019.PubMed/NCBI View Article : Google Scholar

Thomson AK, Kelley BF, Prokop LJ, Murad MH and Baum CL: Risk factors for cutaneous squamous cell carcinoma recurrence, metastasis, and disease-specific death: A systematic review and meta-analysis. JAMA Dermatol. 152:419–428. 2016.PubMed/NCBI View Article : Google Scholar

Wermker K, Kluwig J, Schipmann S, Klein M, Schulze HJ and Hallermann C: Prediction score for lymph node metastasis from cutaneous squamous cell carcinoma of the external ear. Eur J Surg Oncol. 41:128–135. 2015.PubMed/NCBI View Article : Google Scholar

National Library of Medicine: RM-1995 Photoimmunotherapy, as monotherapy or combined with pembrolizumab, in patients with advanced CuSCC and HNSCC. ClinicalTrials.gov ID: NCT05220748. https://clinicaltrials.gov/study/NCT05220748. Accessed April 19, 2023.

An open-label study using ASP-1929 photoimmunotherapy in combination with anti-PD1 therapy in EGRF expressing advanced solid tumors, 2024. https://www.clinicaltrials.gov/study/NCT04305795.

Volovat SR, Ursulescu CL, Moisii LG, Volovat C, Boboc D, Scripcariu D, Amurariti F, Stefanescu C, Stolniceanu CR, Agop M, et al: The landscape of nanovectors for modulation in cancer immunotherapy. Pharmaceutics. 14(397)2022.PubMed/NCBI View Article : Google Scholar

Economopoulou P, de Bree R, Kotsantis I and Psyrri A: Diagnostic tumor markers in head and neck squamous cell carcinoma (HNSCC) in the clinical setting. Front Oncol. 9(827)2019.PubMed/NCBI View Article : Google Scholar

Rolih V, Barutello G, Iussich S, De Maria R, Quaglino E, Buracco P, Cavallo F and Riccardo F: CSPG4: A prototype oncoantigen for translational immunotherapy studies. J Transl Med. 15(151)2017.PubMed/NCBI View Article : Google Scholar

Green A and Olsen C: Cutaneous squamous cell carcinoma. An epidemiological review. Br J Dermatol. 177:373–381. 2017.PubMed/NCBI View Article : Google Scholar

Warta R, Herold-Mende C, Chaisaingmongkol J, Popanda O, Mock A, Mogler C, Osswald F, Herpel E, Küstner S, Eckstein V, et al: Reduced promoter methylation and increased expression of CSPG4 negatively influences survival of HNSCC patients. Int J Cancer. 135:2727–2734. 2014.PubMed/NCBI View Article : Google Scholar

Goldie SJ, Cottle DL, Tan FH, Roslan S, Srivastava S, Brady R, Partridge DD, Auden A, Smyth IM, Jane SM, et al: Loss of GRHL3 leads to TARC/CCL17-mediated keratinocyte proliferation in the epidermis. Cell Death Dis. 9(1072)2018.PubMed/NCBI View Article : Google Scholar

Chahal HS, Lin Y, Ransohoff KJ, Hinds DA, Wu W, Dai HJ, Qureshi AA, Li WQ, Kraft P, Tang JY, et al: Genome-wide association study identifies novel susceptibility loci for cutaneous squamous cell carcinoma. Nat Commun. 7(12048)2016.PubMed/NCBI View Article : Google Scholar

Sánchez-Danés A, Hannezo E, Larsimont JC, Liagre M, Youssef KK, Simons BD and Blanpain C: Defining the clonal dynamics leading to mouse skin tumour initiation. Nature. 536:298–303. 2016.PubMed/NCBI View Article : Google Scholar

Darido C, Georgy SR, Cullinane C, Patridge DD, Walker R, Srivastava S, Roslan S, Carpinelli MR, Dworkin S, Pearson RB and Jane SM: Stage-dependent therapeutic efficacy in PI3K/mTOR-driven squamous cell carcinoma of the skin. Cell Death Differ. 25:1146–1159. 2018.PubMed/NCBI View Article : Google Scholar

Majumdar M, Vouri K and Stallcup WB: Engagement of the NG2 proteoglycan triggers cell spreading via rac and p130cas. Cell Signal. 15:79–84. 2003.PubMed/NCBI View Article : Google Scholar

Sardone F, Santi S, Tagliavini F, Traina F, Merlini L, Squarzoni S, Cescon M, Wagener R, Maraldi NM, Bonaldo P, et al: Collagen VI-NG2 axis in human tendon fibroblasts under conditions mimicking injury response. Matrix Biol. 55:90–105. 2016.PubMed/NCBI View Article : Google Scholar

Liu N, Matsumura H, Kato T, Ichinose S, Takada A, Namiki T, Asakawa K, Morinaga H, Mohri Y, De Arcangelis A, et al: Stem cell competition orchestrates skin homeostasis and ageing. Nature. 568:344–350. 2019.PubMed/NCBI View Article : Google Scholar

Nishihara T, Remacle AG, Angert M, Shubayev I, Shyryaev SA, Liu H, Dolkas J, Chernov AV, Strongin AY and Shubayev VI: Matrix metalloproteinase-14 both sheds cell surface neuronal glial antigen 2 (NG2) proteoglycan on macrophages and governs the response to peripheral nerve injury. J Biol Chem. 290:3693–3707. 2015.PubMed/NCBI View Article : Google Scholar

Beckham TH, Leeman JE, Xie P, Li X, Goldman DA, Zhang Z, Sherman E, McBride S, Riaz N, Lee N and Tsai CJ: Long-term survival in patients with metastatic head and neck squamous cell carcinoma treated with metastasis-directed therapy. Br J Cancer. 121:897–903. 2019.PubMed/NCBI View Article : Google Scholar

Lenouvel D, González-Moles MÁ, Talbaoui A, Ramos-García P, González-Ruiz L, Ruiz-Ávila I and Gil-Montoya JA: An update of knowledge on PD-L1 in head and neck cancers: Physiologic, prognostic and therapeutic perspectives. Oral Dis. 26:511–526. 2020.PubMed/NCBI View Article : Google Scholar

Chen HM, Wang L and Zhou SB: Recent progress in shape memory polymers for biomedical applications. Chin J Polym Sci. 36:905–917. 2018.

Bakst RL, Glastonbury CM, Parvathaneni U, Katabi N, Hu KS and Yom SS: Perineural invasion and perineural tumor spread in head and neck cancer. Int J Radiat Oncol Biol Phys. 103:1109–1124. 2019.PubMed/NCBI View Article : Google Scholar

Das R, Langou S, Le TT, Prasad P, Lin F and Nguyen TD: Electrical stimulation for immune modulation in cancer treatments. Front Bioeng Biotechnol. 9(795300)2022.PubMed/NCBI View Article : Google Scholar

Campana LG, Miklavčič D, Bertino G, Marconato R, Valpione S, Imarisio I, Dieci MV, Granziera E, Cemazar M, Alaibac M and Sersa G: Electrochemotherapy of superficial tumors-current status: Basic principles, operating procedures, shared indicators, and emerging applications. Semin Oncol. 46:173–191. 2019.PubMed/NCBI View Article : Google Scholar

Plaschke CC, Gehl L, Johannesen HH, Fishcher BM, Kjaer A, Lomholt AF and Wessel I: Calcium electroporation for recurrent head and neck cancer: A clinical phase I study. Laryngoscope Investig Otolaryngol. 4:49–56. 2019.PubMed/NCBI View Article : Google Scholar

Caracciolo G: Clinically approved liposomal nanomedicines: Lessons learned from the biomolecular corona. Nanoscale. 10:4167–4172. 2018.PubMed/NCBI View Article : Google Scholar

Ahmad S, Idris RAM, Hanaffi WNW, Perumal K, Boer JC, Plebanski M, Jaafar J, Lim JK and Mohamud R: Cancer nanomedicine and immune system-interactions and challenges. Front Nanotechnol. 3(681305)2021.

Ochoa MC, Minute L, Rodriguez I, Garasa S, Perez-Ruiz E, Inogés S, Melero I and Berraondo P: Antibody-dependent cell cytotoxicity: Immunotherapy strategies enhancing effector NK cells. Immunol Cell Biol. 95:347–355. 2017.PubMed/NCBI View Article : Google Scholar

Niculet E, Bobeica C, Onisor C, Gurau G, Nechita A, Radaschin DS, Tutunaru D, Bujoreanu-Bezman L and Tatu AL: Basal cell carcinoma perineural invasion and suggestive signs of perineural invasion-findings and perspectives. Life (Basel). 13(1406)2023.PubMed/NCBI View Article : Google Scholar

Rehmani HS and Issaeva N: EGFR in head and neck squamous cell carcinoma: Exploring possibilities of novel drug combinations. Ann Transl Med. 8(813)2020.PubMed/NCBI View Article : Google Scholar

Wise-draper TM, Bahig H, Tonneau M, Karived V and Burtness B: Current therapy for metastatic head and neck cancer: Evidence, opportunities, and challenges. Am Soc Clin Oncol Educ Book. 42:1–14. 2022.PubMed/NCBI View Article : Google Scholar

Hepp MV, Eigentler TK, Kähler KC, Herbst RA, Göppner D, Gambichler T, Ulrich J, Dippel E, Loquai C, Schell B, et al: Immune checkpoint blockade with concurrent electrochemotherapy in advanced melanoma: A retrospective multicenter analysis. Cancer Immunol Immunother. 65:951–959. 2016.PubMed/NCBI View Article : Google Scholar

Caramazza L, Nardoni M, De Angelis A, Paolicelli P, Liberti M, Apollonio F and Petralito S: Proof-of-concept of electrical activation of liposome nanocarries: From dry to wet experiments. Front Bioeng Biotechnol. 8(819)2020.PubMed/NCBI View Article : Google Scholar

Parmar K, Mohamed A, Vaish E, Thawani R, Cetnar J and Thein KZ: Immunotherapy in head and neck squamous cell carcinoma: An updated review. Cancer Treat Res Commun. 33(100649)2022.PubMed/NCBI View Article : Google Scholar

Study of Cemiplimab in patients with type of skin cancer stage II to IV cutaneous squamous cell carcinoma, 2023. https://www.clinicaltrials.gov./study/NCT04154943.

National Library of Medicine: Neoadjuvant Cemiplimab for the treatment of resectable NSCLC, HCC, and HNSCC in adult patients. ClinicalTrials.gov ID: NCT03916627. https://clinicaltrials.gov/study/NCT03916627. Accessed May 31, 2023.

National Library of Medicine: Study of adjuvant Cemiplimab versus placebo after surgery and radiation therapy in patients with high risk cutaneous squamous cell carcinoma. ClinicalTrials.gov ID: NCT03969004. https://clinicaltrials.gov/study/NCT03969004. Accessed May 31, 2019.

National Library of Medicine: Pembrolizumab (MK3475) versus placebo following surgery and radiation in participants with locally advanced cutaneous squamous cell carcinoma (MK-3475-630/KEYNOTE-630). ClinicalTrials.gov ID: NCT03833167. https://clinicaltrials.gov/study/NCT03833167. Accessed Febryary 6, 2019.

Rades D, Zwaan I, Soror T, Idel C, Pries R, Bruchhage KL, Hakim SG and Yu NY: Chemoradiation with cisplatin vs carboplatin for squamous cell carcinoma of the head and neck (SCCHN). Cancers (Basel). 15(3278)2023.PubMed/NCBI View Article : Google Scholar

Kurosaki T, Mitani S, Tanaka K, Suzuki S, Kanemura H, Haratani K, Fumita S, Iwasa T, Hayashi H, Yoshida T, et al: Safety and efficacy of cetuximab-containing chemotherapy after immune checkpoint inhibitors for patients with squamous cell carcinoma of the head and neck: # single-center retrospective study. Anticancer Drugs. 32:95–101. 2021.PubMed/NCBI View Article : Google Scholar

Chen YH, Tsai CH, Chen YY, Wang JH, Hung CH and Kuo YH: Real-world comparison of pembrolizumab and nivolumab in advanced hepatocellular carcinoma. BMC Cancer. 23(810)2023.PubMed/NCBI View Article : Google Scholar

Nottage MK, Lin C, Hughes BGM, Kenny L, Smith DD, Houston K and Francesconi A: Prospective study of definitive chemoradiation in locally or regionally advanced squamous cell carcinoma of the skin. Head Neck. 39:679–683. 2017.PubMed/NCBI View Article : Google Scholar

Cowey CL, Robert NJ, Espirito JL, Davis K, Frytak J, Lowy I and Fury MG: Clinical outcomes among unresectable, locally advanced, and metastatic cutaneous squamous cell carcinoma patients treated with systemic therapy. Cancer Med. 9:7381–7387. 2020.PubMed/NCBI View Article : Google Scholar

Lavaud J, Blom A, Longvert C, Magali F, Funck-Brentano E and Saiag P: Pembrolizumab and concurrent hypo-fractionated radiotherapy for advanced non-resectable cutaneous squamous cell carcinoma. Eur J Dermatol. 29:636–640. 2019.PubMed/NCBI View Article : Google Scholar

Fan M, Kang JJ, Lee A, Fan D, Wang H, Kitpanit S, Fox P, Sine K, Mah D, McBride S, et al: Outcomes and toxicities of definitive radiotherapy and reirradiation using 3-dimensional conformal or intensity-modulated (pencil beam) proton therapy for patients with nasal cavity and paranasal sinus malignancies. Cancer. 126:1905–1916. 2020.PubMed/NCBI View Article : Google Scholar

Ogata D, Namikawa K, Otsuka M, Asai J, Kato H, Yasuda M, Maekawa T, Fujimura T, Kato J, Takenouchi T, et al: Systemic treatment of patients with advanced cutaneous squamous cell carcinoma: Response rates and outcomes of the regimes used. Eur J Cancer. 127:108–117. 2020.PubMed/NCBI View Article : Google Scholar

De Felice F, Musio D, De Falco D, Grapulin L, Magnante AL, Caiazzo R, Bulzonetti N and Tombolini V: Definitive weekly hypofractionated radiotherapy in cutaneous squamous cell carcinoma: Response rates and outcomes in elderly patients unfit for surgery. Int J Dermatol. 61:911–915. 2022.PubMed/NCBI View Article : Google Scholar

Voruganti IS, Poon I, Husain ZA, Bayley A, Barnes EA, Zhang L, Chin L, Erler D, Higgins K, Enepekides D, et al: Stereotactic body radiotherapy for head and neck skin cancer. Radiother Oncol. 165:1–7. 2021.PubMed/NCBI View Article : Google Scholar