Leukemia in pregnancy: Diagnosis and therapeutic approach (Review)

Giannakaki,Aikaterini-Gavriela; Giannakaki,Maria-Nektaria; Oikonomou,Efthymios; Nikolettos,Konstantinos; Bothou,Anastasia; Kotanidou,Sonia; Andreou,Sotiris; Kritsotaki,Nektaria; Nalmpanti,Theopi; Spanoudakis,Emmanuel; Iatrakis,George; Damaskos,Christos; Garmpis,Nikolaos; Nikolettos,Nikolaos; Tsikouras,Panagiotis

doi:10.3892/mco.2024.2777

Leukemia in pregnancy: Diagnosis and therapeutic approach (Review)

Authors:
- Aikaterini-Gavriela Giannakaki
- Maria-Nektaria Giannakaki
- Efthymios Oikonomou
- Konstantinos Nikolettos
- Anastasia Bothou
- Sonia Kotanidou
- Sotiris Andreou
- Nektaria Kritsotaki
- Theopi Nalmpanti
- Emmanuel Spanoudakis
- George Iatrakis
- Christos Damaskos
- Nikolaos Garmpis
- Nikolaos Nikolettos
- Panagiotis Tsikouras
View Affiliations

Affiliations: First Department of Obstetrics and Gynecology, Alexandra University Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece, Department of Internal Medicine, Thriasio General Hospital of Elefsina, 19018 Magoula, Greece, Department of Obstetrics and Gynecology, Democritus University of Thrace, 68100 Alexandroupolis, Greece, Neonatal Department, Alexandra University Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece, Department of Hematology, Democritus University of Thrace, 68100 Alexandroupolis, Greece, Department of Obstetrics and Gynecology, Rea Maternity Hospital, National and Kapodistrian University of Athens, 17564 Athens, Greece, Department of Laboratory of Experimental Surgery and Surgical Research, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece, Department of Surgery, Sotiria Hospital, 11527 Athens, Greece
Published online on: August 21, 2024 https://doi.org/10.3892/mco.2024.2777
Article Number: 79
Copyright: © Giannakaki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study aimed to evaluate the epidemiological, diagnostic and therapeutic data of hematological malignancies in pregnancy. Leukemia in pregnancy is rare, and literature data are not extensive. Risk factors, epidemiology and pathogenesis of these diseases are not fully developed. Furthermore, there is a detailed report on the complications in pregnancy and the overall (per trimester) management of these diseases, specifically their treatment strategy. The possibility of achieving a future pregnancy in women with leukemia is described in the present study. The limited clinical research data currently available is mainly due to the inability to conduct randomized clinical trials for ethical reasons. Further research is needed, firstly due to the importance of these diseases for the pregnant woman and the fetus, and secondly, due to the continuous development of novel anticancer drugs that aim to improve the prognosis of these diseases.