Leukemia in pregnancy: Diagnosis and therapeutic approach (Review)
- Authors:
- Aikaterini-Gavriela Giannakaki
- Maria-Nektaria Giannakaki
- Efthymios Oikonomou
- Konstantinos Nikolettos
- Anastasia Bothou
- Sonia Kotanidou
- Sotiris Andreou
- Nektaria Kritsotaki
- Theopi Nalmpanti
- Emmanuel Spanoudakis
- George Iatrakis
- Christos Damaskos
- Nikolaos Garmpis
- Nikolaos Nikolettos
- Panagiotis Tsikouras
-
Affiliations: First Department of Obstetrics and Gynecology, Alexandra University Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece, Department of Internal Medicine, Thriasio General Hospital of Elefsina, 19018 Magoula, Greece, Department of Obstetrics and Gynecology, Democritus University of Thrace, 68100 Alexandroupolis, Greece, Neonatal Department, Alexandra University Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece, Department of Hematology, Democritus University of Thrace, 68100 Alexandroupolis, Greece, Department of Obstetrics and Gynecology, Rea Maternity Hospital, National and Kapodistrian University of Athens, 17564 Athens, Greece, Department of Laboratory of Experimental Surgery and Surgical Research, Medical School, National and Kapodistrian University of Athens, 11528 Athens, Greece, Department of Surgery, Sotiria Hospital, 11527 Athens, Greece - Published online on: August 21, 2024 https://doi.org/10.3892/mco.2024.2777
- Article Number: 79
-
Copyright: © Giannakaki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
Estey E, Hasserjian RP and Döhner H: Distinguishing AML from MDS: A fixed blast percentage may no longer be optimal. Blood. 139:323–332. 2022.PubMed/NCBI View Article : Google Scholar | |
Bispo JAB, Pinheiro PS and Kobetz EK: Epidemiology and etiology of leukemia and lymphoma. Cold Spring Harb Perspect Med. 10(a034819)2020.PubMed/NCBI View Article : Google Scholar | |
Rausch C, Rothenberg-Thurley M, Dufour A, Schneider S, Gittinger H, Sauerland C, Görlich D, Krug U, Berdel WE, Woermann BJ, et al: Validation and refinement of the 2022 European LeukemiaNet genetic risk stratification of acute myeloid leukemia. Leukemia. 37:1234–1244. 2023.PubMed/NCBI View Article : Google Scholar | |
Li Y, Yang W, Devidas M, Winter SS, Kesserwan C, Yang W, Dunsmore KP, Smith C, Qian M, Zhao X, et al: Germline RUNX1 variation and predisposition to childhood acute lymphoblastic leukemia. J Clin Invest. 131(e147898)2021.PubMed/NCBI View Article : Google Scholar : (Epub ahead of print). | |
Voulgaris E, Pentheroudakis G and Pavlidis N: Cancer and pregnancy: A comprehensive review. Surg Oncol. 20:e175–e185. 2011.PubMed/NCBI View Article : Google Scholar | |
Thomas X: Acute myeloid leukemia in the pregnant patient. Eur J Haematol. 95:124–136. 2015.PubMed/NCBI View Article : Google Scholar | |
Zhu D, Tang D, Chai X, Zhang G and Wang Y: Acute leukemia in pregnancy: A single institutional experience with 21 cases at 10 years and a review of the literature. Ann Med. 53:567–575. 2021.PubMed/NCBI View Article : Google Scholar | |
Ali S, Jones GL, Culligan DJ, Marsden PJ, Russell N, Embleton ND and Craddock C: British Committee for Standards in Haematology. Guidelines for the diagnosis and management of acute myeloid leukaemia in pregnancy. Br J Haematol. 170:487–495. 2015.PubMed/NCBI View Article : Google Scholar | |
Grove CS and Vassiliou GS: Acute myeloid leukaemia: A paradigm for the clonal evolution of cancer? Dis Model Mech. 7:941–951. 2014.PubMed/NCBI View Article : Google Scholar | |
Lavudi K, Nuguri SM, Olverson Z, Dhanabalan AK, Patnaik S and Kokkanti RR: Targeting the retinoic acid signaling pathway as a modern precision therapy against cancers. Front Cell Dev Biol. 11(1254612)2023.PubMed/NCBI View Article : Google Scholar | |
Park JH, Qiao B, Panageas KS, Schymura MJ, Jurcic JG, Rosenblat TL, Altman JK, Douer D, Rowe JM and Tallman MS: Early death rate in acute promyelocytic leukemia remains high despite all-trans retinoic acid. Blood. 118:1248–1254. 2011.PubMed/NCBI View Article : Google Scholar | |
Tsuda H, Doi H, Inada T and Shirono K: Successful treatment of acute promyelocytic leukemia in a pregnant woman by using all-trans retinoic acid. Rinsho Ketsueki. 35:717–719. 1994.PubMed/NCBI(In Japanese). | |
Sanz MA, Fenaux P, Tallman MS, Estey EH, Löwenberg B, Naoe T, Lengfelder E, Döhner H, Burnett AK, Chen SJ, et al: Management of acute promyelocytic leukemia: Updated recommendations from an expert panel of the European LeukemiaNet. Blood. 133:1630–1643. 2019.PubMed/NCBI View Article : Google Scholar | |
Santolaria A, Perales A, Montesinos P and Sanz MA: Acute promyelocytic leukemia during pregnancy: A systematic review of the literature. Cancers (Basel). 12(968)2020.PubMed/NCBI View Article : Google Scholar | |
Sanz MA, Grimwade D, Tallman MS, Lowenberg B, Fenaux P, Estey EH, Naoe T, Lengfelder E, Büchner T, Döhner H, et al: Management of acute promyelocytic leukemia: Recommendations from an expert panel on behalf of the European LeukemiaNet. Blood. 113:1875–1891. 2009.PubMed/NCBI View Article : Google Scholar | |
Ssenyonga N, Stiller C, Nakata K, Shalkow J, Redmond S, Bulliard JL, Girardi F, Fowler C, Marcos-Gragera R, Bonaventure A, et al: Worldwide trends in population-based survival for children, adolescents, and young adults diagnosed with leukaemia, by subtype, during 2000-14 (CONCORD-3): Analysis of individual data from 258 cancer registries in 61 countries. Lancet Child Adolesc Health. 6:409–431. 2022.PubMed/NCBI View Article : Google Scholar | |
DeRenzo C, Krenciute G and Gottschalk S: The landscape of CAR T cells beyond acute lymphoblastic leukemia for pediatric solid tumors. Am Soc Clin Oncol Educ Book. 38:830–837. 2018.PubMed/NCBI View Article : Google Scholar | |
Chiaretti S, Zini G and Bassan R: Diagnosis and subclassification of acute lymphoblastic leukemia. Mediterr J Hematol Infect Dis. 6(e2014073)2014.PubMed/NCBI View Article : Google Scholar | |
Ticku J, Oberoi S, Friend S, Busowski J, Langenstroer M and Baidas S: Acute lymphoblastic leukemia in pregnancy: A case report with literature review. Ther Adv Hematol. 4:313–319. 2013.PubMed/NCBI View Article : Google Scholar | |
Farhadfar N, Cerquozzi S, Hessenauer MR, Litzow MR, Hogan WJ, Letendre L, Patnaik MM, Tefferi A and Gangat N: Acute leukemia in pregnancy: A single institution experience with 23 patients. Leuk Lymphoma. 58:1052–1060. 2017.PubMed/NCBI View Article : Google Scholar | |
Nadeem S, Elahi E, Iftikhar I, Umar S, Ahsan B, Ahmad U and Bokhari SW: Management of acute lymphoblastic leukemia during pregnancy: A case report and review of the literature. Cureus. 16(e52489)2024.PubMed/NCBI View Article : Google Scholar | |
Theodora M, Theofanakis C, Fasoulakis ZN, Barbarousi D, Daskalakis G and Rodolakis A: EP685 Management of acute lymphoblastic leukemia in a 26-year-old primigravida. Int J Gynecol Cancer. 29 (Suppl 4):A392.3–A393. 2019. | |
Vlijm-Kievit A, Jorna NGE, Moll E, Pajkrt E, Pals ST, Middeldorp S, Biemond BJ, Zeerleder SS, Tio MA, Kemper EM and Hazenberg MD: Acute lymphoblastic leukemia during the third trimester of pregnancy. Leuk Lymphoma. 59:1274–1276. 2018.PubMed/NCBI View Article : Google Scholar | |
Romero-Morelos P, González-Yebra AL, Muñoz-López D, Lara-Lona E and González-Yebra B: Frequencies of BCR::ABL1 transcripts in patients with chronic myeloid leukemia: A meta-analysis. Genes (Basel). 15(232)2024.PubMed/NCBI View Article : Google Scholar | |
American Cancer Society: Risk Factors for Chronic Myeloid Leukemia. https://www.cancer.org/cancer/types/chronic-myeloid-leukemia/causes-risks-prevention/risk-factors.html. | |
Zhao D, Long X and Wang J: Pharmacovigilance study of BCR-ABL1 tyrosine kinase inhibitors: A safety analysis of the FDA adverse event reporting system. BMC Pharmacol Toxicol. 25(20)2024.PubMed/NCBI View Article : Google Scholar | |
Brehme M, Koschmieder S, Montazeri M, Copland M, Oehler VG, Radich JP, Brümmendorf TH and Schuppert A: Combined population dynamics and entropy modelling supports patient stratification in chronic myeloid leukemia. Sci Rep. 6(24057)2016.PubMed/NCBI View Article : Google Scholar | |
Xue M, Wang Q, Huo L, Wen L, Yang X, Wu Q, Pan J, Cen J, Ruan C, Wu D and Chen S: Clinical characteristics and prognostic significance of chronic myeloid leukemia with rare BCR-ABL1 transcripts. Leuk Lymphoma. 60:3051–3057. 2019.PubMed/NCBI View Article : Google Scholar | |
Yadav U, Solanki SL and Yadav R: Chronic myeloid leukemia with pregnancy: Successful management of pregnancy and delivery with hydroxyurea and imatinib continued till delivery. J Cancer Res Ther. 9:484–486. 2013.PubMed/NCBI View Article : Google Scholar | |
Pye SM, Cortes J, Ault P, Hatfield A, Kantarjian H, Pilot R, Rosti G and Apperley JF: The effects of imatinib on pregnancy outcome. Blood. 111:5505–5508. 2008.PubMed/NCBI View Article : Google Scholar | |
Abruzzese E, Mauro M, Apperley J and Chelysheva E: Tyrosine kinase inhibitors and pregnancy in chronic myeloid leukemia: Opinion, evidence, and recommendations. Ther Adv Hematol. 11(2040620720966120)2020.PubMed/NCBI View Article : Google Scholar | |
Soverini S, De Benedittis C, Mancini M and Martinelli G: Best practices in chronic myeloid leukemia monitoring and management. Oncologist. 21:626–633. 2016.PubMed/NCBI View Article : Google Scholar | |
Zhang S and Kipps TJ: The pathogenesis of chronic lymphocytic leukemia. Annu Rev Pathol. 9:103–118. 2014.PubMed/NCBI View Article : Google Scholar | |
Kipps TJ, Stevenson FK, Wu CJ, Croce CM, Packham G, Wierda WG, O'Brien S, Gribben J and Rai K: Chronic lymphocytic leukaemia. Nat Rev Dis Primers. 3(16096)2017.PubMed/NCBI View Article : Google Scholar | |
Rogers A and Woyach JA: BTK inhibitors and anti-CD20 monoclonal antibodies for treatment-naive elderly patients with CLL. Ther Adv Hematol. 11(2040620720912990)2020.PubMed/NCBI View Article : Google Scholar | |
Hamad N, Kliman D, Best OG, Caramins M, Hertzberg M, Lindeman R, Porter R and Mulligan SP: Chronic lymphocytic leukaemia, monoclonal B-lymphocytosis and pregnancy: Five cases, a literature review and discussion of management. Br J Haematol. 168:350–360. 2015.PubMed/NCBI View Article : Google Scholar | |
Hallek M, Cheson BD, Catovsky D, Caligaris-Cappio F, Dighiero G, Döhner H, Hillmen P, Keating MJ, Montserrat E, Rai KR, et al: Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International workshop on chronic lymphocytic leukemia updating the national cancer institute-working group 1996 guidelines. Blood. 111:5446–5456. 2008.PubMed/NCBI View Article : Google Scholar | |
Luttwak E, Gurevich-Shapiro A, Azem F, Lishner M, Klieger C, Herishanu Y, Perry C and Avivi I: Novel agents for the treatment of lymphomas during pregnancy: A comprehensive literature review. Blood Rev. 49(100831)2021.PubMed/NCBI View Article : Google Scholar | |
Daver N, Nazha A, Kantarjian HM, Haltom R and Ravandi F: Treatment of hairy cell leukemia during pregnancy: Are purine analogues and rituximab viable therapeutic options. Clin Lymphoma Myeloma Leuk. 13:86–89. 2013.PubMed/NCBI View Article : Google Scholar | |
Cannon T, Mobarek D, Wegge J and Tabbara IA: Hairy cell leukemia: Current concepts. Cancer Invest. 26:860–865. 2008.PubMed/NCBI View Article : Google Scholar | |
Munir F, Hardit V, Sheikh IN, AlQahtani S, He J, Cuglievan B, Hosing C, Tewari P and Khazal S: Classical Hodgkin lymphoma: from past to future-A comprehensive review of pathophysiology and therapeutic advances. Int J Mol Sci. 24(10095)2023.PubMed/NCBI View Article : Google Scholar | |
Mazharul M: Complications and Pathophysiology of Hodgkin Lymphoma. J Hematol Thrombo Dis. 10(515)2023. | |
American Cancer Society: Hodgkin Lymphoma Risk Factors, Risk Factors for Hodgkin Disease. https://www.cancer.org/cancer/types/hodgkin-lymphoma/causes-risks-prevention/risk-factors.html. | |
Smith LH, Danielsen B, Allen ME and Cress R: Cancer associated with obstetric delivery: Results of linkage with the California cancer registry. Am J Obstet Gynecol. 189:1128–1135. 2003.PubMed/NCBI View Article : Google Scholar | |
Connors JM: Clinical manifestations and natural history of Hodgkin's lymphoma. Cancer J. 15:124–128. 2009.PubMed/NCBI View Article : Google Scholar | |
Bachanova V and Connors JM: Hodgkin lymphoma in pregnancy. Curr Hematol Malig Rep. 8:211–217. 2013.PubMed/NCBI View Article : Google Scholar | |
Gurevich-Shapiro A and Avivi I: Current treatment of lymphoma in pregnancy. Expert Rev Hematol. 12:449–459. 2019.PubMed/NCBI View Article : Google Scholar | |
Borchmann P, Eichenauer DA and Engert A: State of the art in the treatment of Hodgkin lymphoma. Nat Rev Clin Oncol. 9:450–459. 2012.PubMed/NCBI View Article : Google Scholar | |
Ciccarone M, Cavaceppi P, Tesei C, Brunetti S, Pulsoni A, Annibali O, Gasparoli C, Battistini R, Hohaus S, Pelliccia S, et al: Effects of ABVD chemotherapy on ovarian function: Epidemiology, hormonal dosages and ultrasound morphologic analyses in 270 patients with Hodgkin's disease. Front Oncol. 13(1059393)2023.PubMed/NCBI View Article : Google Scholar | |
Armitage JO, Gascoyne RD, Lunning MA and Cavalli F: Non-Hodgkin lymphoma. Lancet. 390:298–310. 2017.PubMed/NCBI View Article : Google Scholar | |
Jiang L and Li N: B-cell non-Hodgkin lymphoma: Importance of angiogenesis and antiangiogenic therapy. Angiogenesis. 23:515–529. 2020.PubMed/NCBI View Article : Google Scholar | |
Gequelin LCF, Riediger IN, Nakatani SM, Biondo AW and Bonfim CM: Epstein-Barr virus: General factors, virus-related diseases and measurement of viral load after transplant. Rev Bras Hematol Hemoter. 33:383–388. 2011.PubMed/NCBI View Article : Google Scholar | |
Câmara AB and Brandão IA: The non-Hodgkin lymphoma treatment and side effects: A systematic review and meta-analysis. Recent Pat Anticancer Drug Discov: Jan 17, 2023 (Epub ahead of print). | |
Mohseni S, Shojaiefard A, Khorgami Z, Alinejad S, Ghorbani A and Ghafouri A: Peripheral lymphadenopathy: Approach and diagnostic tools. Iran J Med Sci. 39 (2 Suppl):S158–S170. 2014.PubMed/NCBI | |
Pirosa MC and Peccatori FA: Lymphomas in pregnancy. Hematol Oncol. 41 (Suppl 1):S70–S74. 2023.PubMed/NCBI View Article : Google Scholar | |
Dunleavy K and McLintock C: How I treat lymphoma in pregnancy. Blood. 136:2118–2124. 2020.PubMed/NCBI View Article : Google Scholar | |
Evens AM, Advani R, Press OW, Lossos IS, Vose JM, Hernandez-Ilizaliturri FJ, Robinson BK, Otis S, Nadav Dagan L, Abdallah R, et al: Lymphoma occurring during pregnancy: Antenatal therapy, complications, and maternal survival in a multicenter analysis. J Clin Oncol. 31:4132–4139. 2013.PubMed/NCBI View Article : Google Scholar | |
Nooh MM, Rizk SM, Saied NM and Abdelazim SM: Carnosine remedial effect on fertility of male rats receiving cyclophosphamide, hydroxydaunomycin, oncovin and prednisone (CHOP). Andrologia. 53(e14233)2021.PubMed/NCBI View Article : Google Scholar | |
Antoine-Pepeljugoski C and Braunstein MJ: Management of newly diagnosed elderly multiple myeloma patients. Curr Oncol Rep. 21(64)2019.PubMed/NCBI View Article : Google Scholar | |
Ribourtout B and Zandecki M: Plasma cell morphology in multiple myeloma and related disorders. Morphologie. 99:38–62. 2015.PubMed/NCBI View Article : Google Scholar | |
Michels TC and Petersen KE: Multiple myeloma: Diagnosis and treatment. Am Fam Physician. 95:373–383. 2017.PubMed/NCBI | |
Landgren O, Gridley G, Turesson I, Caporaso NE, Goldin LR, Baris D, Fears TR, Hoover RN and Linet MS: Risk of monoclonal gammopathy of undetermined significance (MGUS) and subsequent multiple myeloma among African American and white veterans in the United States. Blood. 107:904–906. 2006.PubMed/NCBI View Article : Google Scholar | |
Kyle RA and Rajkumar SV: Multiple myeloma. N Engl J Med. 351:1860–1873. 2004.PubMed/NCBI View Article : Google Scholar | |
Kyle RA and Rajkumar SV: Multiple myeloma. Blood. 111:2962–2972. 2008.PubMed/NCBI View Article : Google Scholar | |
International Myeloma Working Group. Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: A report of the international myeloma working group. Br J Haematol. 121:749–757. 2003.PubMed/NCBI | |
Kristinsson SY, Minter AR, Korde N, Tan E and Landgren O: Bone disease in multiple myeloma and precursor disease: Novel diagnostic approaches and implications on clinical management. Expert Rev Mol Diagn. 11:593–603. 2011.PubMed/NCBI View Article : Google Scholar | |
Regelink JC, Minnema MC, Terpos E, Kamphuis MH, Raijmakers PG, Pieters-van den Bos IC, Heggelman BGF, Nievelstein RJ, Otten RHJ, van Lammeren-Venema D, et al: Comparison of modern and conventional imaging techniques in establishing multiple myeloma-related bone disease: A systematic review. Br J Haematol. 162:50–61. 2013.PubMed/NCBI View Article : Google Scholar | |
Rajkumar SV: MGUS and smoldering multiple myeloma: Update on pathogenesis, natural history, and management. Hematology Am Soc Hematol Educ Program. 2005:340–345. 2005.PubMed/NCBI View Article : Google Scholar | |
Greipp PR, San Miguel J, Durie BG, Crowley JJ, Barlogie B, Bladé J, Boccadoro M, Child JA, Avet-Loiseau H, Kyle RA, et al: International staging system for multiple myeloma. J Clin Oncol. 23:3412–3420. 2005.PubMed/NCBI View Article : Google Scholar | |
Elgabry G, Spencer L, Siddiqi H, Ojha S and Wandroo F: A report of a symptomatic progressive myeloma during pregnancy and postpartum period from asymptomatic state. Hematol Rep. 15:305–311. 2023.PubMed/NCBI View Article : Google Scholar | |
Rizack T, Mega A, Legare R and Castillo J: Management of hematological malignancies during pregnancy. Am J Hematol. 84:830–841. 2009.PubMed/NCBI View Article : Google Scholar | |
de Montalembert M, Ferster A, Colombatti R, Rees DC and Gulbis B: European Network for Rare and Congenital Anaemias. ENERCA clinical recommendations for disease management and prevention of complications of sickle cell disease in children. Am J Hematol. 86:72–75. 2011.PubMed/NCBI View Article : Google Scholar | |
Kinoshita S, Yamashita K, Iwatsuki M, Sato H, Matsumoto C, Matsumoto T, Shiraishi Y, Yoshida N and Baba H: Disseminated carcinomatosis of the bone marrow from gastric cancer during pregnancy. Clin J Gastroenterol. 12:447–452. 2019.PubMed/NCBI View Article : Google Scholar | |
Sakamoto K, Kanda T, Ohashi M, Kurabayashi T, Serikawa T, Matsunaga M and Hatakeyama K: Management of patients with pregnancy-associated gastric cancer in Japan: A mini-review. Int J Clin Oncol. 14:392–396. 2009.PubMed/NCBI View Article : Google Scholar | |
Song MJ, Park YS, Song HJ, Park SJ, Ahn JY, Choi KD, Lee GH, Jung HY, Yook JH and Kim BS: Prognosis of pregnancy-associated gastric cancer: An age-, sex-, and stage-matched case-control study. Gut Liver. 10:731–738. 2016.PubMed/NCBI View Article : Google Scholar | |
Milojkovic D and Apperley JF: How I treat leukemia during pregnancy. Blood. 123:974–984. 2014.PubMed/NCBI View Article : Google Scholar | |
Krashin E and Lishner M: Managing leukemia during pregnancy. In: Azim H Jr (ed). Managing Cancer during Pregnancy. Springer, Cham, pp175-184, 2016. | |
Van Calsteren K, Verbesselt R, Beijnen J, Devlieger R, De Catte L, Chai DC, Van Bree R, Heyns L, de Hoon J and Amant F: Transplacental transfer of anthracyclines, vinblastine, and 4-hydroxy-cyclophosphamide in a baboon model. Gynecol Oncol. 119:594–600. 2010.PubMed/NCBI View Article : Google Scholar |