Open Access

Molecular mechanism and therapeutic strategies for embryonal tumors with multilayered rosettes in children (Review)

  • Authors:
    • Wen-Qiong Lv
    • Ju Gao
    • Xia Guo
  • View Affiliations

  • Published online on: January 27, 2025     https://doi.org/10.3892/mco.2025.2825
  • Article Number: 30
  • Copyright: © Lv et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Embryonal tumors with multilayered rosettes (ETMR) are relatively rare but highly aggressive intracranial tumors that mainly occur in children under four years of age. Despite high‑intensity and multi‑modal treatment, the five‑year overall survival rate of patients with ETMR remains <30%. Therefore, it is necessary to improve understanding of the molecular biological changes in ETMR. The present review presents an overview of the recent molecular and biological characteristics of ETMR in children, the current recommended treatments, and research into potential targeted strategies based on these findings. ETMR are molecularly characterized by distinct DNA methylation signatures and dysregulated expression of oncogenic miRNAs. Despite increased knowledge of the novel molecular characteristics of ETMR in children, treatment outcomes have only marginally improved. Thus, there is an urgent need to translate these new insights in ETMR biology into more effective treatment.
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March-2025
Volume 22 Issue 3

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Copy and paste a formatted citation
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Spandidos Publications style
Lv W, Gao J and Guo X: Molecular mechanism and therapeutic strategies for embryonal tumors with multilayered rosettes in children (Review). Mol Clin Oncol 22: 30, 2025.
APA
Lv, W., Gao, J., & Guo, X. (2025). Molecular mechanism and therapeutic strategies for embryonal tumors with multilayered rosettes in children (Review). Molecular and Clinical Oncology, 22, 30. https://doi.org/10.3892/mco.2025.2825
MLA
Lv, W., Gao, J., Guo, X."Molecular mechanism and therapeutic strategies for embryonal tumors with multilayered rosettes in children (Review)". Molecular and Clinical Oncology 22.3 (2025): 30.
Chicago
Lv, W., Gao, J., Guo, X."Molecular mechanism and therapeutic strategies for embryonal tumors with multilayered rosettes in children (Review)". Molecular and Clinical Oncology 22, no. 3 (2025): 30. https://doi.org/10.3892/mco.2025.2825