Association of dopaminergic/GABAergic genes with attention deficit hyperactivity disorder in children

  • Authors:
    • Guang-Xin Wang
    • Yan-Hui Ma
    • Shi-Fu Wang
    • Guang-Fang Ren
    • Hui Guo
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  • Published online on: August 9, 2012     https://doi.org/10.3892/mmr.2012.1028
  • Pages: 1093-1098
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Abstract

Attention deficit hyperactivity disorder (ADHD) is the most commonly diagnosed neurobehavioral disorder in children and adolescents; however, its etiology is unknown. In this study, we investigated the association of five polymorphisms in dopaminergic/GABAergic genes with ADHD using polymerase chain reaction-restriction fragment length polymorphism in a group of 54 children with ADHD and 67 healthy controls. The distribution of AA genotype and A allele frequencies of rs5320 in the dopamine beta-hydroxylase gene in ADHD children differed significantly from that in healthy controls; however, no associations were found between four other polymorphisms in dopaminergic/GABAergic genes and ADHD. We also identified the best model consisting of four loci. We conclude that the rs5320 polymorphism may be considered as a genetic risk factor of ADHD, but the other four polymorphisms were not confirmed to be related directly to ADHD. The multilocus of dopaminergic/GABAergic genes acted in combination to affect susceptibility to ADHD in the children studied.
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November 2012
Volume 6 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Wang G, Ma Y, Wang S, Ren G and Guo H: Association of dopaminergic/GABAergic genes with attention deficit hyperactivity disorder in children. Mol Med Rep 6: 1093-1098, 2012
APA
Wang, G., Ma, Y., Wang, S., Ren, G., & Guo, H. (2012). Association of dopaminergic/GABAergic genes with attention deficit hyperactivity disorder in children. Molecular Medicine Reports, 6, 1093-1098. https://doi.org/10.3892/mmr.2012.1028
MLA
Wang, G., Ma, Y., Wang, S., Ren, G., Guo, H."Association of dopaminergic/GABAergic genes with attention deficit hyperactivity disorder in children". Molecular Medicine Reports 6.5 (2012): 1093-1098.
Chicago
Wang, G., Ma, Y., Wang, S., Ren, G., Guo, H."Association of dopaminergic/GABAergic genes with attention deficit hyperactivity disorder in children". Molecular Medicine Reports 6, no. 5 (2012): 1093-1098. https://doi.org/10.3892/mmr.2012.1028