DT-13 suppresses MDA-MB-435 cell adhesion and invasion by inhibiting MMP-2/9 via the p38 MAPK pathway

Zhang,Yuanyuan; Liu,Jihua; Kou,Junping; Yu,Jun; Yu,Boyang

doi:10.3892/mmr.2012.1047

DT-13 suppresses MDA-MB-435 cell adhesion and invasion by inhibiting MMP-2/9 via the p38 MAPK pathway

Authors:
- Yuanyuan Zhang
- Jihua Liu
- Junping Kou
- Jun Yu
- Boyang Yu
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Affiliations: State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, P.R. China, Department of Complex Prescription of TCM, China Pharmaceutical University, Nanjing 211198, P.R. China, Department of Internal Medicine, Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
Published online on: August 24, 2012 https://doi.org/10.3892/mmr.2012.1047
Pages: 1121-1125

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Abstract

Previous research has shown that the Dwarf lilyturf tuber has antitumor effects. The antitumor ability of DT-13, a saponin monomer isolated from the roots of the Dwarf lilyturf tuber, is discussed in this study. The results showed that DT-13 inhibited the proliferation, adhesion and invasion of MDA-MB-435 cells. DT-13 decreased the excretion and expression of MMP-2/9. Furthermore, DT-13 inhibited the phosphorylation of p38 in MDA-MB-435 cells. In conclusion, the results suggest that DT-13 possesses anticancer and antimetastatic properties by inhibiting the invasion of cancer cells.

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