Dual role of acetaminophen in promoting hepatoma cell apoptosis and kidney fibroblast proliferation
- Authors:
- Yung‑Luen Yu
- Giou‑Teng Yiang
- Pei‑Lun Chou
- Hsu‑Hung Tseng
- Tsai‑Kun Wu
- Yu‑Ting Hung
- Pei‑Shiuan Lin
- Shu‑Yu Lin
- Hsiao‑Chun Liu
- Wei‑Jung Chang
- Chyou‑Wei Wei
-
Affiliations: Graduate Institute of Cancer Biology and Center for Molecular Medicine, China Medical University, Taichung 404, Taiwan, R.O.C., Department of Emergency Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei 231, Taiwan, R.O.C., Division of Allergy‑Immunology‑Rheumatology, Department of Internal Medicine, Saint Mary's Hospital Luodong, Yilan 265, Taiwan, R.O.C. , Division of General Surgery, Taichung Hospital, Ministry of Health and Welfare, Taichung 403, Taiwan, R.O.C., 2The Ph.D. Program for Cancer Biology and Drug Discovery, China Medical University, Taichung 404, Taiwan, R.O.C., Department of Nutrition, Master Program of Biomedical Nutrition, Hungkuang University, Taichung 433, Taiwan, R.O.C., Department of Nutrition, Master Program of Biomedical Nutrition, Hungkuang University, Taichung 433, Taiwan, R.O.C., Department of Nursing, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei 231, Taiwan, R.O.C. - Published online on: March 28, 2014 https://doi.org/10.3892/mmr.2014.2085
- Pages: 2077-2084
-
Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].
This article is mentioned in:
Abstract
Rumack BH: Acetaminophen misconceptions. Hepatology. 40:10–15. 2004. View Article : Google Scholar | |
Cuzzolin L, Antonucci R and Fanos V: Paracetamol (acetaminophen) efficacy and safety in the newborn. Curr Drug Metab. 14:178–185. 2013.PubMed/NCBI | |
Klotz U: Paracetamol (acetaminophen) - a popular and widely used nonopioid analgesic. Arzneimittelforschung. 62:355–359. 2012. View Article : Google Scholar : PubMed/NCBI | |
Sullivan JE and Farrar HC: Section on Clinical Pharmacology and Therapeutics, Committee on Drugs: Fever and antipyretic use in children. Pediatrics. 127:580–587. 2011. View Article : Google Scholar : PubMed/NCBI | |
Young RJ: Dextropropoxyphene overdosage. Pharmacological considerations and clinical management. Drugs. 26:70–79. 1983. View Article : Google Scholar : PubMed/NCBI | |
Simkin S, Hawton K, Kapur N and Gunnell D: What can be done to reduce mortality from paracetamol overdoses? A patient interview study. QJM. 105:41–51. 2012. View Article : Google Scholar : PubMed/NCBI | |
Hawton K, Bergen H, Simkin S, et al: Impact of different pack sizes of paracetamol in the United Kingdom and Ireland on intentional overdoses: a comparative study. BMC Public Health. 11:4602011. View Article : Google Scholar : PubMed/NCBI | |
Hawton K, Townsend E, Deeks J, et al: Effects of legislation restricting pack sizes of paracetamol and salicylate on self poisoning in the United Kingdom: before and after study. BMJ. 322:1203–1207. 2001. View Article : Google Scholar : PubMed/NCBI | |
Daly FF, Fountain JS, Murray L, Graudins A and Buckley NA: Guidelines for the management of paracetamol poisoning in Australia and New Zealand - explanation and elaboration. A consensus statement from clinical toxicologists consulting to the Australasian poisons information centres. Med J Aust. 188:296–301. 2008. | |
Gopi KS, Reddy AG, Jyothi K and Kumar BA: Acetaminophen-in duced hepato- and nephrotoxicity and amelioration by silymarin and Terminalia chebula in rats. Toxicol Int. 17:64–66. 2010. View Article : Google Scholar : PubMed/NCBI | |
Abdel-Zaher AO, Abdel-Hady RH, Mahmoud MM and Farrag MM: The potential protective role of alpha-lipoic acid against acetaminophen-induced hepatic and renal damage. Toxicology. 243:261–270. 2008. View Article : Google Scholar : PubMed/NCBI | |
Cermik H, Taslipinar MY, Aydin I, et al: The relationship between N-acetylcysteine, hyperbaric oxygen, and inflammation in a rat model of acetaminophen-induced nephrotoxicity. Inflammation. 36:1145–1152. 2013. View Article : Google Scholar | |
Ucar F, Taslipinar MY, Alp BF, et al: The effects of N-acetylcysteine and ozone therapy on oxidative stress and inflammation in acetaminophen-induced nephrotoxicity model. Ren Fail. 35:640–647. 2013. View Article : Google Scholar : PubMed/NCBI | |
Liang YL, Zhang ZH, Liu XJ, et al: Melatonin protects against apoptosis-inducing factor (AIF)-dependent cell death during acetaminophen-induced acute liver failure. PLoS One. 7:e519112012. View Article : Google Scholar | |
Amaral SS, Oliveira AG, Marques PE, et al: Altered responsiveness to extracellular ATP enhances acetaminophen hepatotoxicity. Cell Commun Signal. 11:102013. View Article : Google Scholar : PubMed/NCBI | |
Badmann A, Langsch S, Keogh A, Brunner T, Kaufmann T and Corazza N: TRAIL enhances paracetamol-induced liver sinusoidal endothelial cell death in a Bim- and Bid-dependent manner. Cell Death Dis. 3:e4472012. View Article : Google Scholar : PubMed/NCBI | |
Badmann A, Keough A, Kaufmann T, Bouillet P, Brunner T and Corazza N: Role of TRAIL and the pro-apoptotic Bcl-2 homolog Bim in acetaminophen-induced liver damage. Cell Death Dis. 2:e1712011. View Article : Google Scholar : PubMed/NCBI | |
McGill MR, Yan HM, Ramachandran A, Murray GJ, Rollins DE and Jaeschke H: HepaRG cells: a human model to study mechanisms of acetaminophen hepatotoxicity. Hepatology. 53:974–982. 2011. View Article : Google Scholar : PubMed/NCBI | |
Zhao X, Cong X, Zheng L, Xu L, Yin L and Peng J: Dioscin, a natural steroid saponin, shows remarkable protective effect against acetaminophen-induced liver damage in vitro and in vivo. Toxicol Lett. 214:69–80. 2012. View Article : Google Scholar | |
Mobasher MA, Gonzalez-Rodriguez A, Santamaria B, et al: Protein tyrosine phosphatase 1B modulates GSK3beta/Nrf2 and IGFIR signaling pathways in acetaminophen-induced hepatotoxicity. Cell Death Dis. 4:e6262013. View Article : Google Scholar : PubMed/NCBI | |
Ramachandran A, McGill MR, Xie Y, Ni HM, Ding WX and Jaeschke H: Receptor interacting protein kinase 3 is a critical early mediator of acetaminophen-induced hepatocyte necrosis in mice. Hepatology. 58:2099–2108. 2013. View Article : Google Scholar : PubMed/NCBI | |
Ahmad ST, Arjumand W, Nafees S, et al: Hesperidin alleviates acetaminophen induced toxicity in Wistar rats by abrogation of oxidative stress, apoptosis and inflammation. Toxicol Lett. 208:149–161. 2012. View Article : Google Scholar : PubMed/NCBI | |
Inkielewicz-Stepniak I and Knap N: Effect of exposure to fluoride and acetaminophen on oxidative/nitrosative status of liver and kidney in male and female rats. Pharmacol Rep. 64:902–911. 2012. View Article : Google Scholar : PubMed/NCBI | |
Slitt AM, Dominick PK, Roberts JC and Cohen SD: Effect of ribose cysteine pretreatment on hepatic and renal acetaminophen metabolite formation and glutathione depletion. Basic Clin Pharmacol Toxicol. 96:487–494. 2005. View Article : Google Scholar : PubMed/NCBI | |
Yousef MI, Omar SA, El-Guendi MI and Abdelmegid LA: Potential protective effects of quercetin and curcumin on paracetamol-induced histological changes, oxidative stress, impaired liver and kidney functions and haematotoxicity in rat. Food Chem Toxicol. 48:3246–3261. 2010. View Article : Google Scholar | |
Zhang Y, Jia Y, Yang M, Yang P, Tian Y, Xiao A and Wen A: The impaired disposition of probe drugs is due to both liver and kidney dysfunctions in CCl(4)-model rats. Environ Toxicol Pharmacol. 33:453–458. 2012. View Article : Google Scholar : PubMed/NCBI | |
Zhao YL, Zhou GD, Yang HB, Wang JB, Shan LM, Li RS and Xiao XH: Rhein protects against acetaminophen-induced hepatic and renal toxicity. Food Chem Toxicol. 49:1705–1710. 2011. View Article : Google Scholar : PubMed/NCBI | |
Roomi MW, Kalinovsky T, Ivanov V, Rath M and Niedzwiecki A: A nutrient mixture prevents acetaminophen hepatic and renal toxicity in ICR mice. Hum Exp Toxicol. 27:223–230. 2008. View Article : Google Scholar : PubMed/NCBI | |
Posadas I, Santos P and Cena V: Acetaminophen induces human neuroblastoma cell death through NFKB activation. PLoS One. 7:e501602012. View Article : Google Scholar : PubMed/NCBI | |
Posadas I, Vellecco V, Santos P, Prieto-Lloret J and Cena V: Acetaminophen potentiates staurosporine-induced death in a human neuroblastoma cell line. Br J Pharmacol. 150:577–585. 2007. View Article : Google Scholar : PubMed/NCBI | |
Jaeschke H: Comments on ‘glycogen synthase kinase-3 mediates acetaminophen-induced apoptosis in human hepatoma cells’. J Pharmacol Exp Ther. 314:1401–1404. 2005. | |
Macanas-Pirard P, Yaacob NS, Lee PC, Holder JC, Hinton RH and Kass GE: Glycogen synthase kinase-3 mediates acetaminophen-induced apoptosis in human hepatoma cells. J Pharmacol Exp Ther. 313:780–789. 2005. View Article : Google Scholar : PubMed/NCBI | |
Bilir A, Guneri AD and Altinoz MA: Acetaminophen and DMSO modulate growth and gemcitabine cytotoxicity in FM3A breast cancer cells in vitro. Neoplasma. 51:460–464. 2004.PubMed/NCBI | |
Wu YJ, Neuwelt AJ, Muldoon LL and Neuwelt EA: Acetaminophen enhances cisplatin- and paclitaxel-mediated cytotoxicity to SKOV3 human ovarian carcinoma. Anticancer Res. 33:2391–2400. 2013.PubMed/NCBI | |
Reszka KJ, Britigan LH, Rasmussen GT, Wagner BA, Burns CP and Britigan BE: Acetaminophen stimulates the peroxidative metabolism of anthracyclines. Arch Biochem Biophys. 427:16–29. 2004. View Article : Google Scholar : PubMed/NCBI | |
Manov I, Bashenko Y, Eliaz-Wolkowicz A, Mizrahi M, Liran O and Iancu TC: High-dose acetaminophen inhibits the lethal effect of doxorubicin in HepG2 cells: the role of P-glycoprotein and mitogen-activated protein kinase p44/42 pathway. J Pharmacol Exp Ther. 322:1013–1022. 2007. View Article : Google Scholar : PubMed/NCBI | |
Kidokoro K, Satoh M, Nagasu H, et al: Tacrolimus induces glomerular injury via endothelial dysfunction caused by reactive oxygen species and inflammatory change. Kidney Blood Press Res. 35:549–557. 2012. View Article : Google Scholar : PubMed/NCBI | |
Stacchiotti A, Li Volti G, Lavazza A, et al: Different role of Schisandrin B on mercury-induced renal damage in vivo and in vitro. Toxicology. 286:48–57. 2011. View Article : Google Scholar : PubMed/NCBI | |
Suddek GM: Sunitinib improves chemotherapeutic efficacy and ameliorates cisplatin-induced nephrotoxicity in experimental animals. Cancer Chemother Pharmacol. 67:1035–1044. 2011. View Article : Google Scholar : PubMed/NCBI | |
Neria F, Castilla MA, Sanchez RF, et al: Inhibition of JAK2 protects renal endothelial and epithelial cells from oxidative stress and cyclosporin A toxicity. Kidney Int. 75:227–234. 2009. View Article : Google Scholar : PubMed/NCBI | |
Jang HS, Kim JI, Jung KJ, Kim J, Han KH and Park KM: Bone marrow-derived cells play a major role in kidney fibrosis via proliferation and differentiation in the infiltrated site. Biochim Biophys Acta. 1832.817–825. 2013.PubMed/NCBI | |
Seikrit C, Henkel C, van Roeyen CR, et al: Biological responses to PDGF-AA versus PDGF-CC in renal fibroblasts. Nephrol Dial Transplant. 28:889–900. 2013. View Article : Google Scholar : PubMed/NCBI | |
Kim SH, Yu MA, Ryu ES, Jang YH and Kang DH: Indoxyl sulfate-induced epithelial-to-mesenchymal transition and apoptosis of renal tubular cells as novel mechanisms of progression of renal disease. Lab Invest. 92:488–498. 2012. View Article : Google Scholar : PubMed/NCBI | |
Abdul Hamid Z, Budin SB, Wen Jie N, Hamid A, Husain K and Mohamed J: Nephroprotective effects of Zingiber zerumbet Smith ethyl acetate extract against paracetamol-induced nephrotoxicity and oxidative stress in rats. J Zhejiang Univ Sci B. 13:176–185. 2012. | |
Chen N, Aleksa K, Woodland C, Rieder M and Koren G: The effect of N-acetylcysteine on ifosfamide-induced nephrotoxicity: in vitro studies in renal tubular cells. Transl Res. 150:51–57. 2007. View Article : Google Scholar : PubMed/NCBI | |
Isik B, Bayrak R, Akcay A and Sogut S: Erdosteine against acetaminophen induced renal toxicity. Mol Cell Biochem. 287:185–191. 2006. View Article : Google Scholar : PubMed/NCBI | |
Lorz C, Justo P, Sanz A, Subira D, Egido J and Ortiz A: Paracetamol-induced renal tubular injury: a role for ER stress. J Am Soc Nephrol. 15:380–389. 2004. View Article : Google Scholar : PubMed/NCBI | |
Lorz C, Justo P, Sanz AB, Egido J and Ortiz A: Role of Bcl-xL in paracetamol-induced tubular epithelial cell death. Kidney Int. 67:592–601. 2005. View Article : Google Scholar : PubMed/NCBI | |
Boulares AH, Zoltoski AJ, Stoica BA, Cuvillier O and Smulson ME: Acetaminophen induces a caspase-dependent and Bcl-XL sensitive apoptosis in human hepatoma cells and lymphocytes. Pharmacol Toxicol. 90:38–50. 2002. View Article : Google Scholar : PubMed/NCBI | |
Manov I, Hirsh M and Iancu TC: N-acetylcysteine does not protect HepG2 cells against acetaminophen-induced apoptosis. Basic Clin Pharmacol Toxicol. 94:213–225. 2004. View Article : Google Scholar : PubMed/NCBI | |
Manov I, Hirsh M and Iancu TC: Acetaminophen hepatotoxicity and mechanisms of its protection by N-acetylcysteine: a study of Hep3B cells. Exp Toxicol Pathol. 53:489–500. 2002. View Article : Google Scholar : PubMed/NCBI | |
Wu CS, Yen CJ, Chou RH, et al: Cancer-associated carbohydrate antigens as potential biomarkers for hepatocellular carcinoma. PLoS One. 7:e394662012. View Article : Google Scholar : PubMed/NCBI | |
Yu YL, Su KJ, Chen CJ, et al: Synergistic anti-tumor activity of isochaihulactone and paclitaxel on human lung cancer cells. J Cell Physiol. 227:213–222. 2012. View Article : Google Scholar : PubMed/NCBI | |
Zhang L, Li J, Jiang Z, et al: Inhibition of aquaporin-1 expression by RNAi protects against aristolochic acid I-induced apoptosis in human proximal tubular epithelial (HK-2) cells. Biochem Biophys Res Commun. 405:68–73. 2011. View Article : Google Scholar : PubMed/NCBI | |
Yu YL, Chou RH, Wu CH, et al: Nuclear EGFR suppresses ribonuclease activity of polynucleotide phosphorylase through DNAPK-mediated phosphorylation at serine 776. J Biol Chem. 287:31015–31026. 2012. View Article : Google Scholar : PubMed/NCBI | |
Chen KH, Li PC, Lin WH, Chien CT and Low BH: Depression by a green tea extract of alcohol-induced oxidative stress and lipogenesis in rat liver. Biosci Biotechnol Biochem. 75:1668–1676. 2011. View Article : Google Scholar : PubMed/NCBI | |
Lin BR, Yu CJ, Chen WC, et al: Green tea extract supplement reduces D-galactosamine-induced acute liver injury by inhibition of apoptotic and proinflammatory signaling. J Biomed Sci. 16:352009. View Article : Google Scholar : PubMed/NCBI | |
Yu YL, Yu SL, Su KJ, et al: Extended O6-methylguanine methyltransferase promoter hypermethylation following n-butylidenephthalide combined with 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) on inhibition of human hepatocellular carcinoma cell growth. J Agric Food Chem. 58:1630–1638. 2010. View Article : Google Scholar | |
Yu YL, Wei CW, Chen YL, Chen MH and Yiang GT: Immunotherapy of breast cancer by single delivery with rAAV2-mediated interleukin-15 expression. Int J Oncol. 36:365–370. 2010.PubMed/NCBI | |
Yiang GT, Chen YH, Chou PL, Chang WJ, Wei CW and Yu YL: The NS3 protease and helicase domains of Japanese encephalitis virus trigger cell death via caspase-dependent and -independent pathways. Mol Med Rep. 7:826–830. 2013.PubMed/NCBI | |
Yiang GT, Yu YL, Hu SC, Chen MH, Wang JJ and Wei CW: PKC and MEK pathways inhibit caspase-9/-3-mediated cytotoxicity in differentiated cells. FEBS Lett. 582:881–885. 2008. View Article : Google Scholar : PubMed/NCBI | |
Wei CW, Lin CC, Yu YL, et al: n-Butylidenephthalide induced apoptosis in the A549 human lung adenocarcinoma cell line by coupled down-regulation of AP-2alpha and telomerase activity. Acta Pharmacol Sin. 30:1297–1306. 2009. View Article : Google Scholar : PubMed/NCBI | |
Hassane S, Leonhard WN, van der Wal A, et al: Elevated TGFbeta-Smad signalling in experimental Pkd1 models and human patients with polycystic kidney disease. J Pathol. 222:21–31. 2010.PubMed/NCBI | |
Edward M, Quinn JA, Mukherjee S, et al: Gadodiamide contrast agent ‘activates’ fibroblasts: a possible cause of nephrogenic systemic fibrosis. J Pathol. 214:584–593. 2008. | |
Kumari A and Kakkar P: Lupeol protects against acetaminophen-induced oxidative stress and cell death in rat primary hepatocytes. Food Chem Toxicol. 50:1781–1789. 2012. View Article : Google Scholar : PubMed/NCBI | |
Anoush M, Eghbal MA, Fathiazad F, Hamzeiy H and Kouzehkonani NS: The protective effects of garlic extract against acetaminophen-induced oxidative stress and glutathione depletion. Pak J Biol Sci. 12:765–771. 2009. View Article : Google Scholar : PubMed/NCBI | |
Yao Y, Yang J, Wang D, et al: The aqueous extract of Lycopus lucidus Turcz ameliorates streptozotocin-induced diabetic renal damage via inhibiting TGF-beta1 signaling pathway. Phytomedicine. 20:1160–1167. 2013. | |
Hsieh TJ, Hsieh PC, Tsai YH, et al: Melamine induces human renal proximal tubular cell injury via transforming growth factor-beta and oxidative stress. Toxicol Sci. 130:17–32. 2012. View Article : Google Scholar : PubMed/NCBI | |
Hills CE, Siamantouras E, Smith SW, Cockwell P, Liu KK and Squires PE: TGFβ modulates cell-to-cell communication in early epithelial-to-mesenchymal transition. Diabetologia. 55:812–824. 2012. | |
Xu Y, Yang S, Huang J, Ruan S, Zheng Z and Lin J: Tgf-β1 induces autophagy and promotes apoptosis in renal tubular epithelial cells. Int J Mol Med. 29:781–790. 2012. | |
Yoshikawa M, Hishikawa K, Idei M and Fujita T: Trichostatin a prevents TGF-beta1-induced apoptosis by inhibiting ERK activation in human renal tubular epithelial cells. Eur J Pharmacol. 642:28–36. 2010. View Article : Google Scholar : PubMed/NCBI | |
Li R, Wang Y, Liu Y, et al: Curcumin inhibits transforming growth factor-β1-induced EMT via PPARγ pathway, not Smad pathway in renal tubular epithelial cells. PLoS One. 8:e588482013. | |
Han WQ, Zhu Q, Hu J, Li PL, Zhang F and Li N: Hypoxia-inducible factor prolyl-hydroxylase-2 mediates transforming growth factor beta 1-induced epithelial-mesenchymal transition in renal tubular cells. Biochim Biophys Acta. 1833.1454–1462. 2013. | |
Yan HD, Li XZ, Xie JM and Li M: Effects of advanced glycation end products on renal fibrosis and oxidative stress in cultured NRK-49F cells. Chin Med J (Engl). 120:787–793. 2007. | |
Guo W, Xu H, Huang WY, et al: Prohibitin suppresses renal interstitial fibroblasts proliferation and phenotypic change induced by transforming growth factor-beta1. Zhonghua Yi Xue Za Zhi. 87:1660–1665. 2007.(In Chinese). | |
Levanon D, Manov I and Iancu TC: Qualitative and quantitative analysis of the effects of acetaminophen and N-acetylcysteine on the surface morphology of Hep3B hepatoma cells in vitro. Ultrastruct Pathol. 28:3–14. 2004.PubMed/NCBI | |
Williamson K, Wahl MS and Mycyk MB: Direct comparison of 20-hour IV, 36-hour oral, and 72-hour oral acetylcysteine for treatment of acute acetaminophen poisoning. Am J Ther. 20:37–40. 2013. View Article : Google Scholar : PubMed/NCBI | |
Saritas A, Kandis H, Baltaci D, et al: N-Acetyl cysteine and erdosteine treatment in acetaminophen-induced liver damage. Toxicol Ind Health. Oct 15–2012.(Epub ahead of print). |