A novel panel of microRNAs provides a sensitive and specific tool for the diagnosis of breast cancer

  • Authors:
    • Jinhua Luo
    • Qing Zhao
    • Wei Zhang
    • Zhuhong Zhang
    • Jing Gao
    • Chunyan Zhang
    • Yali Li
    • Yaping Tian
  • View Affiliations

  • Published online on: May 27, 2014     https://doi.org/10.3892/mmr.2014.2274
  • Pages: 785-791
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Abstract

Breast cancer has a high fatality rate. Early diagnosis reduces the rate of mortality; therefore, novel diagnostic methods are urgently required. The present study investigated the correlation of serum microRNA (miRNA/miR) expression with breast cancer, and tested a panel of miRNAs as promising potential biomarkers for breast cancer. Six miRNAs (miR‑374, miR‑666‑5p, miR‑451, miR‑148a, miR‑27a and miR‑30b) were selected for analysis and their differential expression levels were quantified using qPCR. The results demonstrated that four out of the six candidate miRNAs were significantly downregulated in breast cancer patients (miR‑451, P=0.000; miR‑148a, P=0.021; miR‑27a, P=0.013 and miR‑30b, P=0.001). A panel of miRNAs consisting of the four downregulated miRNAs was able to distinguish breast cancer from healthy controls, with an area under the receiver operating characteristic curve of 95.3%, a sensitivity of 94.7% and a specificity of 82.8%. Thus, this panel of miRNAs may be used as a sensitive and specific tool for the diagnosis of breast cancer.
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August-2014
Volume 10 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Luo J, Zhao Q, Zhang W, Zhang Z, Gao J, Zhang C, Li Y and Tian Y: A novel panel of microRNAs provides a sensitive and specific tool for the diagnosis of breast cancer. Mol Med Rep 10: 785-791, 2014
APA
Luo, J., Zhao, Q., Zhang, W., Zhang, Z., Gao, J., Zhang, C. ... Tian, Y. (2014). A novel panel of microRNAs provides a sensitive and specific tool for the diagnosis of breast cancer. Molecular Medicine Reports, 10, 785-791. https://doi.org/10.3892/mmr.2014.2274
MLA
Luo, J., Zhao, Q., Zhang, W., Zhang, Z., Gao, J., Zhang, C., Li, Y., Tian, Y."A novel panel of microRNAs provides a sensitive and specific tool for the diagnosis of breast cancer". Molecular Medicine Reports 10.2 (2014): 785-791.
Chicago
Luo, J., Zhao, Q., Zhang, W., Zhang, Z., Gao, J., Zhang, C., Li, Y., Tian, Y."A novel panel of microRNAs provides a sensitive and specific tool for the diagnosis of breast cancer". Molecular Medicine Reports 10, no. 2 (2014): 785-791. https://doi.org/10.3892/mmr.2014.2274