Identification of biomarkers for endometriosis in plasma from patients with endometriosis using a proteomics approach

  • Authors:
    • Jin-Hee Hwang
    • Kyu-Sup Lee
    • Jong-Kil Joo
    • Tao Wang
    • Jung-Bin Son
    • Jong‑Ha  Park
    • Dae-Youn Hwang
    • Man-Ho Choi
    • Hong-Gu Lee
  • View Affiliations

  • Published online on: May 30, 2014     https://doi.org/10.3892/mmr.2014.2291
  • Pages: 725-730
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Abstract

The present study aimed to examine potential biomarkers for the diagnosis of endometriosis. A plasma-based proteomic approach, including 2-dimentional electrophoresis and mass spectrometry, was used. Samples were obtained from patients with (n=15) and without (n=15) endometriosis, or from mice with surgically induced endometriosis. Seven spots corresponding to six differentially expressed proteins were identified in the human plasma samples. However, only haptoglobin (Hp) was identified to be significantly decreased in the plasma levels of patients with endometriosis (P<0.05) and in mice with surgically induced endometriosis (P<0.05). The results demonstrated that Hp was downregulated in females with endometriosis, and it therefore, may be a useful diagnostic tool as a biomarker of endometriosis.
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August-2014
Volume 10 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Hwang J, Lee K, Joo J, Wang T, Son J, Park JH, Hwang D, Choi M and Lee H: Identification of biomarkers for endometriosis in plasma from patients with endometriosis using a proteomics approach. Mol Med Rep 10: 725-730, 2014
APA
Hwang, J., Lee, K., Joo, J., Wang, T., Son, J., Park, J. ... Lee, H. (2014). Identification of biomarkers for endometriosis in plasma from patients with endometriosis using a proteomics approach. Molecular Medicine Reports, 10, 725-730. https://doi.org/10.3892/mmr.2014.2291
MLA
Hwang, J., Lee, K., Joo, J., Wang, T., Son, J., Park, J., Hwang, D., Choi, M., Lee, H."Identification of biomarkers for endometriosis in plasma from patients with endometriosis using a proteomics approach". Molecular Medicine Reports 10.2 (2014): 725-730.
Chicago
Hwang, J., Lee, K., Joo, J., Wang, T., Son, J., Park, J., Hwang, D., Choi, M., Lee, H."Identification of biomarkers for endometriosis in plasma from patients with endometriosis using a proteomics approach". Molecular Medicine Reports 10, no. 2 (2014): 725-730. https://doi.org/10.3892/mmr.2014.2291