MicroRNA-181 inhibits glioma cell proliferation by targeting cyclin B1

  • Authors:
    • Fei Wang
    • Ji-Yong Sun
    • You‑Hou Zhu
    • Ning-Tao Liu
    • Yi-Fang Wu
    • Fei Yu
  • View Affiliations

  • Published online on: July 28, 2014     https://doi.org/10.3892/mmr.2014.2423
  • Pages: 2160-2164
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Abstract

Small non‑coding RNAs from the microRNA family (miRs) are important elements in the posttranscriptional control of gene expression. miRs are known to regulate numerous cellular processes and are of crucial importance during development and in pathological conditions, including tumor initiation and progression. In the present study, the expression level of miR‑181 was reduced in glioma tissues compared with the adjacent normal tissues. The enforced expression of miR‑181 was able to inhibit cell proliferation in U251 and SHG‑44 cells, while antisense miR‑181 oligonucleotides (antisense miR‑181) enhanced cell proliferation. At the molecular level, these results further revealed that the expression of cyclin B1, a positive cell‑cycle regulator, was negatively regulated by miR‑181. Therefore, the data reported in the present study demonstrates that miR‑181 is an important regulator in glioma. These results may contribute to improving the understanding of the key misregulated miRNAs in glioma.
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October 2014
Volume 10 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Wang F, Sun J, Zhu YH, Liu N, Wu Y and Yu F: MicroRNA-181 inhibits glioma cell proliferation by targeting cyclin B1. Mol Med Rep 10: 2160-2164, 2014
APA
Wang, F., Sun, J., Zhu, Y., Liu, N., Wu, Y., & Yu, F. (2014). MicroRNA-181 inhibits glioma cell proliferation by targeting cyclin B1. Molecular Medicine Reports, 10, 2160-2164. https://doi.org/10.3892/mmr.2014.2423
MLA
Wang, F., Sun, J., Zhu, Y., Liu, N., Wu, Y., Yu, F."MicroRNA-181 inhibits glioma cell proliferation by targeting cyclin B1". Molecular Medicine Reports 10.4 (2014): 2160-2164.
Chicago
Wang, F., Sun, J., Zhu, Y., Liu, N., Wu, Y., Yu, F."MicroRNA-181 inhibits glioma cell proliferation by targeting cyclin B1". Molecular Medicine Reports 10, no. 4 (2014): 2160-2164. https://doi.org/10.3892/mmr.2014.2423