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Spindle cell oncocytoma of the adenohypophysis: Two case reports and a review of the literature

  • Authors:
    • Qingchun Mu
    • Jinlu Yu
    • Limei Qu
    • Xitong Hu
    • Haijun Gao
    • Pengfei Liu
    • Xu Zheng
    • Yuxue Sun
    • Haiyan Huang

  • View Affiliations

  • Published online on: March 12, 2015     https://doi.org/10.3892/mmr.2015.3476
  • Pages: 871-876

  • Copyright: © Mu et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

Spindle cell oncocytoma (SCO) of the adenohypophysis is a rare tumor in the sellar region. Due to its rarity, little information is available regarding SCO. It is often misdiagnosed as another type of sellar tumor. In the present study, two cases of SCO were reported. One patient was a 35‑year‑old female presenting with decreased visual acuity, amenorrhea and lactation. The other patient was a 62‑year‑old female with no clear symptoms or signs. Cranial magnetic resonance imaging (MRI) revealed a suprasellar mass with marked homogeneous enhancement in the two cases. A craniotomy was performed to completely resect the tumors. The tumors were immunopositive for vimentin, epithelial membrane antigen (EMA), S‑100 and thyroid transcription factor‑1 (TTF‑1). The tumors were pathologically diagnosed as SCO. No recurrence occurred during the follow‑up period of 15‑21 months. In the present study, the literature was reviewed and the clinical data, imaging features, intraoperative findings and recurrence of 24 cases were analyzed in the literature as well as the present two cases. The average age of the SCO patients was 58.5 years and no gender preference was observed for the disease. The tumor exhibited homogeneous enhancement on the MRI. The intraoperative assessment revealed that the tumor had a rich blood supply and the SCO tumors were immunopositive for vimentin, S‑100, EMA and TTF‑1. These findings provided valuable clinical data for the preoperative diagnosis and surgical removal of SCO tumors.
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July-2015
Volume 12 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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  • Impact Factor: 3.4
  • Ranked Medicine Research and Experimental
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  • CiteScore: 7.6
  • CiteScore Rank: Q1: #82/347 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 0.647
  • SCImago Journal Rank (SJR): 0.781
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Spandidos Publications style
Mu Q, Yu J, Qu L, Hu X, Gao H, Liu P, Zheng X, Sun Y and Huang H: Spindle cell oncocytoma of the adenohypophysis: Two case reports and a review of the literature. Mol Med Rep 12: 871-876, 2015.
APA
Mu, Q., Yu, J., Qu, L., Hu, X., Gao, H., Liu, P. ... Huang, H. (2015). Spindle cell oncocytoma of the adenohypophysis: Two case reports and a review of the literature. Molecular Medicine Reports, 12, 871-876. https://doi.org/10.3892/mmr.2015.3476
MLA
Mu, Q., Yu, J., Qu, L., Hu, X., Gao, H., Liu, P., Zheng, X., Sun, Y., Huang, H."Spindle cell oncocytoma of the adenohypophysis: Two case reports and a review of the literature". Molecular Medicine Reports 12.1 (2015): 871-876.
Chicago
Mu, Q., Yu, J., Qu, L., Hu, X., Gao, H., Liu, P., Zheng, X., Sun, Y., Huang, H."Spindle cell oncocytoma of the adenohypophysis: Two case reports and a review of the literature". Molecular Medicine Reports 12, no. 1 (2015): 871-876. https://doi.org/10.3892/mmr.2015.3476