Sevoflurane ameliorates intestinal ischemia-reperfusion-induced lung injury by inhibiting the synergistic action between mast cell activation and oxidative stress

Luo,Chenfang; Yuan,Dongdong; Zhao,Weicheng; Chen,Huixin; Luo,Gangjian; Su,Guangjie; Hei,Ziqing

doi:10.3892/mmr.2015.3527

Sevoflurane ameliorates intestinal ischemia-reperfusion-induced lung injury by inhibiting the synergistic action between mast cell activation and oxidative stress

Authors:
- Chenfang Luo
- Dongdong Yuan
- Weicheng Zhao
- Huixin Chen
- Gangjian Luo
- Guangjie Su
- Ziqing Hei
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Affiliations: Department of Anesthesiology, The Third Afﬁliated Hospital, Sun Yat‑Sen University, Guangzhou, Guangdong 510630, P.R. China, Department of Anesthesiology, The First People's Hospital of Foshan, Foshan, Guangdong 528000, P.R. China
Published online on: March 23, 2015 https://doi.org/10.3892/mmr.2015.3527
Pages: 1082-1090
Copyright: © Luo et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

Preconditioning with sevoflurane (SEV) can protect against ischemia-reperfusion injury in several organs, however, the benefits of SEV against acute lung injury (ALI), induced by intestinal ischemia‑reperfusion (IIR), and the underlying mechanisms remain to be elucidated. The present study was designed to investigate the effects of SEV preconditioning on IIR‑mediated ALI and the associated mechanisms in a rat model. Female Sprague‑Dawley rats treated with 2.3% SEV or apocynin (AP), an inhibitor of NADPH oxidase, were subjected to 75 min superior mesenteric artery occlusion followed by 2 h reperfusion in the presence or absence of the mast cell degranulator compound 48/80 (CP). SEV and AP were observed to downregulate the protein expression levels of p47phox and gp91phox in the lungs of normal rats. IIR resulted in severe lung injury, characterized by significant increases in pathological injury scores, lung wet/dry weight ratio, protein expression levels of p47phox, gp91phox and ICAM‑1, the presence of hydrogen peroxide, malondydehyde and interleukin‑6, and the activity of myeloperoxidase. In addition, significant reductions were observed in the expression of prosurfactant protein C, accompanied by an increase in MC degranulation, demonstrated by significant elevations in the number of mast cells, expression levels of tryptase and the concentration of β‑hexosaminidase. These changes were further augmented in the presence of CP. In addition, SEV and AP preconditioning significantly alleviated the above alterations induced by IIR alone or in combination with CP. These findings suggested that SEV and AP attenuated IIR‑induced ALI by inhibiting NADPH oxidase and the synergistic action between oxidative stress and mast cell activation.

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