Translocation of BBAP from the cytoplasm to the nucleus reduces the metastatic ability of vemurafenib-resistant SKMEL28 cells

  • Authors:
    • Nguyen Dinh Thang
    • Nguyen Van Minh
    • Pham Thu Huong
  • View Affiliations

  • Published online on: December 2, 2016     https://doi.org/10.3892/mmr.2016.5976
  • Pages: 317-322
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Abstract

To the best of our knowledge, the present study is the first to demonstrate that treatment of vemurafenib-resistant SKMEL28 (SKMEL28-R) cells with paclitaxel leads to a shift in localization of the E3-ligase BBAP from the cytoplasm to the nucleus, consequently decreasing the metastatic ability of this cell line. The present study revealed that the movement of BBAP from the cytoplasm to nucleus initiated a change in cell morphology. In addition, the translocation of BBAP led to a decrease of metastatic characteristics in SKMEL28‑R cells, including migration and invasion via downregulation of the phosphorylated form of focal adhesion kinase and N‑cadherin, as well as an upregulation of p21 and E-cadherin. The results of the present study suggested that BBAP may not only be a novel biomarker for melanoma, but also a novel therapeutic target for treatment of metastatic melanoma.
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January-2017
Volume 15 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Thang ND, Minh NV and Huong PT: Translocation of BBAP from the cytoplasm to the nucleus reduces the metastatic ability of vemurafenib-resistant SKMEL28 cells. Mol Med Rep 15: 317-322, 2017
APA
Thang, N.D., Minh, N.V., & Huong, P.T. (2017). Translocation of BBAP from the cytoplasm to the nucleus reduces the metastatic ability of vemurafenib-resistant SKMEL28 cells. Molecular Medicine Reports, 15, 317-322. https://doi.org/10.3892/mmr.2016.5976
MLA
Thang, N. D., Minh, N. V., Huong, P. T."Translocation of BBAP from the cytoplasm to the nucleus reduces the metastatic ability of vemurafenib-resistant SKMEL28 cells". Molecular Medicine Reports 15.1 (2017): 317-322.
Chicago
Thang, N. D., Minh, N. V., Huong, P. T."Translocation of BBAP from the cytoplasm to the nucleus reduces the metastatic ability of vemurafenib-resistant SKMEL28 cells". Molecular Medicine Reports 15, no. 1 (2017): 317-322. https://doi.org/10.3892/mmr.2016.5976