Clinical significance of inflammatory cytokine and chemokine expression in hand, foot and mouth disease

  • Authors:
    • Ping Shao
    • Xiaoxin Wu
    • Hongbo Li
    • Zhigang Wu
    • Zongxin Yang
    • Hangping Yao
  • View Affiliations

  • Published online on: March 15, 2017     https://doi.org/10.3892/mmr.2017.6324
  • Pages: 2859-2866
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Abstract

The present study examined the relationship between cytokine and chemokine expression and the clinical presentation of hand, foot and mouth disease (HFMD), which is currently unclear. The present study involved 28 patients with mild HFMD, 44 patients with severe HFMD and 26 healthy children. Venous blood was tested for cytokine [interleukin (IL)‑4, IL‑12, IL‑18, tumor necrosis factor‑α (TNF‑α), interferon‑γ (IFN‑γ)] and chemokine expression [IL‑8, regulated on activation, normal T cell expressed and secreted (RANTES), monocyte chemoattractant protein‑1 (MCP‑1) and IFN-γ-inducible protein‑10 (IP‑10)]. Stool samples from the patients were tested for enterovirus 71 (EV71) RNA using reverse transcription-polymerase chain reaction. The results indicated that all cytokine/chemokine levels were increased in patients with severe HFMD compared with in patients with mild HFMD or control subjects. In addition, RANTES, MCP‑1, IL‑4, IL‑12 and IL‑18 levels were higher in mild HFMD patients than in the controls. In patients with severe HFMD, all expression levels (with the exception of IL‑8 and IL‑4) were increased in patients with encephalitis plus pulmonary edema compared with those with encephalitis alone. Furthermore, all levels (with the exception of IL‑8) were increased in EV71‑positive patients compared with EV71‑negative patients. In mild HFMD, all levels (with the exception of IL‑8 and IL‑4) were increased in EV71‑positive patients compared with EV71‑negative patients. However, in severe HFMD, only RANTES, IP‑10 and IFN‑γ levels were increased in EV71‑positive patients compared with EV71‑negative patients. In the EV71‑negative group, all levels were increased in severe HFMD compared with mild HFMD. In the EV71‑positive group, all levels (with the exception of IL‑8) were increased in severe HFMD compared with mild HFMD. These results indicated that cytokines and chemokines participate in HFMD pathogenesis, and may be useful to monitor disease progression and predict prognosis.
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May-2017
Volume 15 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Shao P, Wu X, Li H, Wu Z, Yang Z and Yao H: Clinical significance of inflammatory cytokine and chemokine expression in hand, foot and mouth disease. Mol Med Rep 15: 2859-2866, 2017
APA
Shao, P., Wu, X., Li, H., Wu, Z., Yang, Z., & Yao, H. (2017). Clinical significance of inflammatory cytokine and chemokine expression in hand, foot and mouth disease. Molecular Medicine Reports, 15, 2859-2866. https://doi.org/10.3892/mmr.2017.6324
MLA
Shao, P., Wu, X., Li, H., Wu, Z., Yang, Z., Yao, H."Clinical significance of inflammatory cytokine and chemokine expression in hand, foot and mouth disease". Molecular Medicine Reports 15.5 (2017): 2859-2866.
Chicago
Shao, P., Wu, X., Li, H., Wu, Z., Yang, Z., Yao, H."Clinical significance of inflammatory cytokine and chemokine expression in hand, foot and mouth disease". Molecular Medicine Reports 15, no. 5 (2017): 2859-2866. https://doi.org/10.3892/mmr.2017.6324