Open Access

Protection of FK506 against neuronal apoptosis and axonal injury following experimental diffuse axonal injury

  • Authors:
    • Ting‑Qin Huang
    • Jin‑Ning Song
    • Feng‑Wei Zheng
    • Hong‑Gang Pang
    • Yong‑Lin Zhao
    • Hua Gu
    • Jun‑Jie Zhao
  • View Affiliations

  • Published online on: March 22, 2017     https://doi.org/10.3892/mmr.2017.6350
  • Pages: 3001-3010
  • Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Diffuse axonal injury (DAI) is the most common and significant pathological features of traumatic brain injury (TBI). However, there are still no effective drugs to combat the formation and progression of DAI in affected individuals. FK506, also known as tacrolimus, is an immunosuppressive drug, which is widely used in transplantation medicine for the reduction of allograft rejection. Previous studies have identified that FK506 may play an important role in the nerve protective effect of the central nervous system. In the present study, apoptosis of neuronal cells was observed following the induction of experimental DAI. The results demonstrated that it was closely related with the upregulation of death‑associated protein kinase 1 (DAPK1). It was hypothesized that FK506 may inhibit the activity of DAPK1 by inhibiting calcineurin activity, which may be primarily involved in anti‑apoptosis following DAI induction. Through researching the expression of nerve regeneration associated proteins (NF‑H and GAP‑43) following DAI, the present study provides novel data to suggest that FK506 promotes axon formation and nerve regeneration following experimental DAI. Therefore, FK506 may be a potent therapeutic for inhibiting nerve injury, as well as promoting the nerve regeneration following DAI.
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May-2017
Volume 15 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Huang TQ, Song JN, Zheng FW, Pang HG, Zhao YL, Gu H and Zhao JJ: Protection of FK506 against neuronal apoptosis and axonal injury following experimental diffuse axonal injury. Mol Med Rep 15: 3001-3010, 2017
APA
Huang, T., Song, J., Zheng, F., Pang, H., Zhao, Y., Gu, H., & Zhao, J. (2017). Protection of FK506 against neuronal apoptosis and axonal injury following experimental diffuse axonal injury. Molecular Medicine Reports, 15, 3001-3010. https://doi.org/10.3892/mmr.2017.6350
MLA
Huang, T., Song, J., Zheng, F., Pang, H., Zhao, Y., Gu, H., Zhao, J."Protection of FK506 against neuronal apoptosis and axonal injury following experimental diffuse axonal injury". Molecular Medicine Reports 15.5 (2017): 3001-3010.
Chicago
Huang, T., Song, J., Zheng, F., Pang, H., Zhao, Y., Gu, H., Zhao, J."Protection of FK506 against neuronal apoptosis and axonal injury following experimental diffuse axonal injury". Molecular Medicine Reports 15, no. 5 (2017): 3001-3010. https://doi.org/10.3892/mmr.2017.6350