Viral and host factors associated with outcomes of hepatitis C virus infection (Review)
- Authors:
- Zehui Yan
- Yuming Wang
-
Affiliations: Department of Infectious Diseases, Southwest Hospital, Third Military Medical University, Shapingba, Chongqing 400038, P.R. China - Published online on: March 22, 2017 https://doi.org/10.3892/mmr.2017.6351
- Pages: 2909-2924
This article is mentioned in:
Abstract
Webster DP, Klenerman P and Dusheiko GM: Hepatitis C. Lancet. 385:1124–1135. 2015. View Article : Google Scholar : PubMed/NCBI | |
Micallef JM, Kaldor JM and Dore GJ: Spontaneous viral clearance following acute hepatitis C infection: A systematic review of longitudinal studies. J Viral Hepat. 13:34–41. 2006. View Article : Google Scholar : PubMed/NCBI | |
Shepard CW, Finelli L and Alter MJ: Global epidemiology of hepatitis C virus infection. Lancet Infect Dis. 5:558–567. 2005. View Article : Google Scholar : PubMed/NCBI | |
McHutchison JG, Lawitz EJ, Shiffman ML, Muir AJ, Galler GW, McCone J, Nyberg LM, Lee WM, Ghalib RH, Schiff ER, et al: Peginterferon alfa-2b or alfa-2a with ribavirin for treatment of hepatitis C infection. N Engl J Med. 361:580–593. 2009. View Article : Google Scholar : PubMed/NCBI | |
Ghany MG, Strader DB, Thomas DL and Seeff LB: American Association for the Study of Liver Diseases: Diagnosis, management, and treatment of hepatitis C: An update. Hepatology. 49:1335–1374. 2009. View Article : Google Scholar : PubMed/NCBI | |
Fried MW, Shiffman ML, Reddy KR, Smith C, Marinos G, Gonçales FL Jr, Häussinger D, Diago M, Carosi G, Dhumeaux D, et al: Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med. 347:975–982. 2002. View Article : Google Scholar : PubMed/NCBI | |
Aghemo A and De Francesco R: New horizons in hepatitis C antiviral therapy with direct-acting antivirals. Hepatology. 58:428–438. 2013. View Article : Google Scholar : PubMed/NCBI | |
Rauch A, Gaudieri S, Thio C and Bochud PY: Host genetic determinants of spontaneous hepatitis C clearance. Pharmacogenomics. 10:1819–1837. 2009. View Article : Google Scholar : PubMed/NCBI | |
Bowen DG and Walker CM: Adaptive immune responses in acute and chronic hepatitis C virus infection. Nature. 436:946–952. 2005. View Article : Google Scholar : PubMed/NCBI | |
Doyle JS, Hellard ME and Thompson AJ: The role of viral and host genetics in natural history and treatment of chronic HCV infection. Best Pract Res Clin Gastroenterol. 26:413–427. 2012. View Article : Google Scholar : PubMed/NCBI | |
Bull RA, Luciani F, McElroy K, Gaudieri S, Pham ST, Chopra A, Cameron B, Maher L, Dore GJ, White PA and Lloyd AR: Sequential bottlenecks drive viral evolution in early acute hepatitis C virus infection. PLoS Pathog. 7:e10022432011. View Article : Google Scholar : PubMed/NCBI | |
Bochud PY, Cai T, Overbeck K, Bochud M, Dufour JF, Müllhaupt B, Borovicka J, Heim M, Moradpour D, Cerny A, et al: Genotype 3 is associated with accelerated fibrosis progression in chronic hepatitis C. J Hepatol. 51:655–666. 2009. View Article : Google Scholar : PubMed/NCBI | |
Pearlman BL and Traub N: Sustained virologic response to antiviral therapy for chronic hepatitis C virus infection: A cure and so much more. Clin Infect Dis. 52:889–900. 2011. View Article : Google Scholar : PubMed/NCBI | |
Zhu Y and Chen S: Antiviral treatment of hepatitis C virus infection and factors affecting efficacy. World J Gastroenterol. 19:8963–8973. 2013. View Article : Google Scholar : PubMed/NCBI | |
Hadziyannis SJ, Sette H Jr, Morgan TR, Balan V, Diago M, Marcellin P, Ramadori G, Bodenheimer H Jr, Bernstein D, Rizzetto M, et al: Peginterferon-alpha2a and ribavirin combination therapy in chronic hepatitis C: A randomized study of treatment duration and ribavirin dose. Ann Intern Med. 140:346–355. 2004. View Article : Google Scholar : PubMed/NCBI | |
Khuroo MS, Khuroo MS and Dahab ST: Meta-analysis: A randomized trial of peginterferon plus ribavirin for the initial treatment of chronic hepatitis C genotype 4. Aliment Pharmacol Ther. 20:931–938. 2004. View Article : Google Scholar : PubMed/NCBI | |
Nguyen MH, Trinh HN, Garcia R, Nguyen G, Lam KD and Keeffe EB: Higher rate of sustained virologic response in chronic hepatitis C genotype 6 treated with 48 weeks versus 24 weeks of peginterferon plus ribavirin. Am J Gastroenterol. 103:1131–1135. 2008. View Article : Google Scholar : PubMed/NCBI | |
Foster GR, Hézode C, Bronowicki JP, Carosi G, Weiland O, Verlinden L, van Heeswijk R, van Baelen B, Picchio G and Beumont M: Telaprevir alone or with peginterferon and ribavirin reduces HCV RNA in patients with chronic genotype 2 but not genotype 3 infections. Gastroenterology. 141:881–889, e1. 2011. View Article : Google Scholar : PubMed/NCBI | |
Howe J, Graham D, McMonagle P, Curry S, Chase R, Lahser F, Ogert RA, Strizki J, Barnard RJBO, Zhang R, et al: 844In vitro characterization of the pan-genotyope activity of the HCV NS3/4A protease inhibitors Boceprevir and Telapreevir. J Hepatology. 56:S3292012. View Article : Google Scholar | |
Jacobson IM, McHutchison JG, Dusheiko G, Di Bisceglie AM, Reddy KR, Bzowej NH, Marcellin P, Muir AJ, Ferenci P, Flisiak R, et al: Telaprevir for previously untreated chronic hepatitis C virus infection. N Engl J Med. 364:2405–2416. 2011. View Article : Google Scholar : PubMed/NCBI | |
Zeuzem S, Andreone P, Pol S, Lawitz E, Diago M, Roberts S, Focaccia R, Younossi Z, Foster GR, Horban A, et al: Telaprevir for retreatment of HCV infection. N Engl J Med. 364:2417–2428. 2011. View Article : Google Scholar : PubMed/NCBI | |
Poordad F, McCone J Jr, Bacon BR, Bruno S, Manns MP, Sulkowski MS, Jacobson IM, Reddy KR, Goodman ZD, Boparai N, et al: Boceprevir for untreated chronic HCV genotype 1 infection. N Engl J Med. 364:1195–1206. 2011. View Article : Google Scholar : PubMed/NCBI | |
Bacon BR, Gordon SC, Lawitz E, Marcellin P, Vierling JM, Zeuzem S, Poordad F, Goodman ZD, Sings HL, Boparai N, et al: Boceprevir for previously treated chronic HCV genotype 1 infection. N Engl J Med. 364:1207–1217. 2011. View Article : Google Scholar : PubMed/NCBI | |
Vierling J, Flamm S, Gordon S, Lawitz E, Bronowicki JP, Davis M, Yoshida E, Pedicone LD, Deng W, Treitel M, et al: Efficacy of boceprevir in prior null responders to peginterferon/ribavirin: The PROVIDE study. Hepatology. 54:796A2011. | |
Sulkowski M, Gardiner D, Lawitz E, Hinestrosa F, Nelson D, Thuluvath P, Rodriguez-Torres M, Lok A, Schwartz H, Reddy KR, et al: 1422 Potent Viral Suppression with all-Oral Combination of Daclatasvir (NS5A Inhibitor) and GS-7977 (NS5B Inhibitor), +/− ribavirin, in treatment-naive patients with chronic HCV GT1, 2, OR 3. J Hepatology. 56:S5602012. View Article : Google Scholar | |
Gane EJ, Stedman CA, Hyland RH, Sorensen RD, Symonds WT, Hindes RG and Berrey MM: 1113 electron: Once daily PSI-7977 Plus RBV in HCV GT1/2/3. J Hepatology. 56:S438–S439. 2012. View Article : Google Scholar | |
Gane EJ, Stedman CA, Hyland RH, Ding X, Svarovskaia E, Symonds WT, Hindes RG and Berrey MM: Nucleotide polymerase inhibitor sofosbuvir plus ribavirin for hepatitis C. N Engl J Med. 368:34–44. 2013. View Article : Google Scholar : PubMed/NCBI | |
Moreno C, Hezode C, Marcellin P, Bourgeois S, Francque S, Samuel D, Zoulim F, Grange JD, Shukla U, Lenz O, et al: Efficacy and safety of simeprevir with Peg-IFN/ribavirin in naive or experienced patients infected with chronic HCV genotype 4. J Hepatol. 62:1047–1055. 2015. View Article : Google Scholar : PubMed/NCBI | |
Zeuzem S, Soriano V, Asselah T, et al: SVR4 and SVR12 with an interferon-free regimen of BI-201335 and BI-207127, +/−ribavirin, in treatment-naıve patients with chronic genotype-1 HCV infection: Interim results of SOUND-C2. J Hepatol (EASL 47th Annual Meeting abstracts). 56:542012. | |
Lok AS, Gardiner DF, Lawitz E, Martorell C, Everson GT, Ghalib R, Reindollar R, Rustgi V, McPhee F, Wind-Rotolo M, et al: Preliminary study of two antiviral agents for hepatitis C genotype 1. N Engl J Med. 366:216–224. 2012. View Article : Google Scholar : PubMed/NCBI | |
Jacobson IM, Brown RS Jr, Freilich B, Afdhal N, Kwo PY, Santoro J, Becker S, Wakil AE, Pound D, Godofsky E, et al: Peginterferon alfa-2b and weight-based or flat-dose ribavirin in chronic hepatitis C patients: A randomized trial. Hepatology. 46:971–981. 2007. View Article : Google Scholar : PubMed/NCBI | |
Shiffman ML, Suter F, Bacon BR, Nelson D, Harley H, Solá R, Shafran SD, Barange K, Lin A, Soman A and Zeuzem S: ACCELERATE Investigators: Peginterferon alfa-2a and ribavirin for 16 or 24 weeks in HCV genotype 2 or 3. N Engl J Med. 357:124–134. 2007. View Article : Google Scholar : PubMed/NCBI | |
Zeuzem S, Buti M, Ferenci P, Sperl J, Horsmans Y, Cianciara J, Ibranyi E, Weiland O, Noviello S, Brass C and Albrecht J: Efficacy of 24 weeks treatment with peginterferon alfa-2b plus ribavirin in patients with chronic hepatitis C infected with genotype 1 and low pretreatment viremia. J Hepatol. 44:97–103. 2006. View Article : Google Scholar : PubMed/NCBI | |
Hopkins S, Bobardt M, Chatterji U, Garcia-Rivera JA, Lim P and Gallay PA: The cyclophilin inhibitor SCY-635 disrupts hepatitis C virus NS5A-cyclophilin A complexes. Antimicrob Agents Chemother. 56:3888–3897. 2012. View Article : Google Scholar : PubMed/NCBI | |
Zeuzem S, Fried MW, Reddy KR, et al: Improving the clinical relevance of pretreatment viral load as a predictor of sustained virological response (SVR) in patients infected with hepatitis C genotype 1 treated with peginterferon alfa-2a (40KD) (PEGASYS (R)) plus ribavirin (COPEGUS (R)). Hepatology. 44:(S1). 267A–268A. 2006. | |
European Association for the Study of the Liver: EASL Clinical Practice Guidelines: Management of hepatitis C virus infection. J Hepatol. 55:245–264. 2011. View Article : Google Scholar : PubMed/NCBI | |
Rocco A, Compare D, Coccoli P, Esposito C, Di Spirito A, Barbato A, Strazzullo P and Nardone G: Vitamin B12 supplementation improves rates of sustained viral response in patients chronically infected with hepatitis C virus. Gut. 62:766–773. 2013. View Article : Google Scholar : PubMed/NCBI | |
Kurosaki M, Sakamoto N, Iwasaki M, Sakamoto M, Suzuki Y, Hiramatsu N, Sugauchi F, Tamori A, Nakagawa M and Izumi N: Sequences in the interferon sensitivity-determining region and core region of hepatitis C virus impact pretreatment prediction of response to PEG-interferon plus ribavirin: Data mining analysis. J Med Virol. 83:445–452. 2011. View Article : Google Scholar : PubMed/NCBI | |
Yen YH, Hung CH, Hu TH, Chen CH, Wu CM, Wang JH, Lu SN and Lee CM: Mutations in the interferon sensitivity-determining region (nonstructural 5A amino acid 2209–2248) in patients with hepatitis C-1b infection and correlating response to combined therapy of pegylated interferon and ribavirin. Aliment Pharmacol Ther. 27:72–79. 2008. View Article : Google Scholar : PubMed/NCBI | |
Zeuzem S, Lee JH and Roth WK: Mutations in the nonstructural 5A gene of European hepatitis C virus isolates and response to interferon alfa. Hepatology. 25:740–744. 1997. View Article : Google Scholar : PubMed/NCBI | |
Duverlie G, Khorsi H, Castelain S, Jaillon O, Izopet J, Lunel F, Eb F, Penin F and Wychowski C: Sequence analysis of the NS5A protein of European hepatitis C virus 1b isolates and relation to interferon sensitivity. J Gen Virol. 79:1373–1381. 1998. View Article : Google Scholar : PubMed/NCBI | |
El-Shamy A, Nagano-Fujii M, Sasase N, Imoto S, Kim SR and Hotta H: Sequence variation in hepatitis C virus nonstructural protein 5A predicts clinical outcome of pegylated interferon/ribavirin combination therapy. Hepatology. 48:38–47. 2008. View Article : Google Scholar : PubMed/NCBI | |
Akuta N, Suzuki F, Sezaki H, Suzuki Y, Hosaka T, Someya T, Kobayashi M, Saitoh S, Watahiki S, Sato J, et al: Association of amino acid substitution pattern in core protein of hepatitis C virus genotype 1b high viral load and non-virological response to interferon-ribavirin combination therapy. Intervirology. 48:372–380. 2005. View Article : Google Scholar : PubMed/NCBI | |
Akuta N, Suzuki F, Kawamura Y, Yatsuji H, Sezaki H, Suzuki Y, Hosaka T, Kobayashi M, Kobayashi M, Arase Y, et al: Predictive factors of early and sustained responses to peginterferon plus ribavirin combination therapy in Japanese patients infected with hepatitis C virus genotype 1b: Amino acid substitutions in the core region and low-density lipoprotein cholesterol levels. J Hepatol. 46:403–410. 2007. View Article : Google Scholar : PubMed/NCBI | |
Akuta N, Suzuki F, Hirakawa M, Kawamura Y, Yatsuji H, Sezaki H, Suzuki Y, Hosaka T, Kobayashi M, Kobayashi M, et al: Amino acid substitution in hepatitis C virus core region and genetic variation near the interleukin 28B gene predict viral response to telaprevir with peginterferon and ribavirin. Hepatology. 52:421–429. 2010. View Article : Google Scholar : PubMed/NCBI | |
Donlin MJ, Cannon NA, Aurora R, Li J, Wahed AS, Di Bisceglie AM and Tavis JE: Virahep-C Study Group: Contribution of genome-wide HCV genetic differences to outcome of interferon-based therapy in Caucasian American and African American patients. PLoS One. 5:e90322010. View Article : Google Scholar : PubMed/NCBI | |
Aurora R, Donlin MJ, Cannon NA and Tavis JE: Genome-wide hepatitis C virus amino acid covariance networks can predict response to antiviral therapy in humans. J Clin Invest. 119:225–236. 2009.PubMed/NCBI | |
Halfon P and Locarnini S: Hepatitis C virus resistance to protease inhibitors. J Hepatol. 55:192–206. 2011. View Article : Google Scholar : PubMed/NCBI | |
McHutchison JG, Manns MP, Muir AJ, Terrault NA, Jacobson IM, Afdhal NH, Heathcote EJ, Zeuzem S, Reesink HW, Garg J, et al: Telaprevir for previously treated chronic HCV infection. N Engl J Med. 362:1292–1303. 2010. View Article : Google Scholar : PubMed/NCBI | |
Bartels DJ, Zhou Y, Zhang EZ, Marcial M, Byrn RA, Pfeiffer T, Tigges AM, Adiwijaya BS, Lin C, Kwong AD and Kieffer TL: Natural prevalence of hepatitis C virus variants with decreased sensitivity to NS3.4A protease inhibitors in treatment-naive subjects. J Infect Dis. 198:800–807. 2008. View Article : Google Scholar : PubMed/NCBI | |
Kieffer TL, Sarrazin C, Miller JS, Welker MW, Forestier N, Reesink HW, Kwong AD and Zeuzem S: Telaprevir and pegylated interferon-alpha-2a inhibit wild-type and resistant genotype 1 hepatitis C virus replication in patients. Hepatology. 46:631–639. 2007. View Article : Google Scholar : PubMed/NCBI | |
Sarrazin C and Zeuzem S: Resistance to direct antiviral agents in patients with hepatitis C virus infection. Gastroenterology. 138:447–462. 2010. View Article : Google Scholar : PubMed/NCBI | |
Thomas DL, Thio CL, Martin MP, Qi Y, Ge D, O'Huigin C, Kidd J, Kidd K, Khakoo SI, Alexander G, et al: Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature. 461:798–801. 2009. View Article : Google Scholar : PubMed/NCBI | |
Rauch A, Kutalik Z, Descombes P, Cai T, Di Iulio J, Mueller T, Bochud M, Battegay M, Bernasconi E, Borovicka J, et al: Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: A genome-wide association study. Gastroenterology. 138:1338–1345. 2010. View Article : Google Scholar : PubMed/NCBI | |
Kenny-Walsh E: Clinical outcomes after hepatitis C infection from contaminated anti-D immune globulin. Irish Hepatology Research Group. N Engl J Med. 340:1228–1233. 1999. View Article : Google Scholar : PubMed/NCBI | |
Grebely J, Petoumenos K, Hellard M, Matthews GV, Suppiah V, Applegate T, Yeung B, Marks P, Rawlinson W, Lloyd AR, et al: Potential role for interleukin-28B genotype in treatment decision-making in recent hepatitis C virus infection. Hepatology. 52:1216–1224. 2010. View Article : Google Scholar : PubMed/NCBI | |
Tillmann HL, Thompson AJ, Patel K, Wiese M, Tenckhoff H, Nischalke HD, Lokhnygina Y, Kullig U, Göbel U, Capka E, et al: A polymorphism near IL28B is associated with spontaneous clearance of acute hepatitis C virus and jaundice. Gastroenterology. 139:1586–1592. 2010. View Article : Google Scholar : PubMed/NCBI | |
Ramadori G and Christ B: Cytokines and the hepatic acute-phase response. Semin Liver Dis. 19:141–155. 1999. View Article : Google Scholar : PubMed/NCBI | |
Gao B: Cytokines, STATs and liver disease. Cell Mol Immunol. 2:92–100. 2005.PubMed/NCBI | |
Fishman D, Faulds G, Jeffery R, Mohamed-Ali V, Yudkin JS, Humphries S and Woo P: The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest. 102:1369–1376. 1998. View Article : Google Scholar : PubMed/NCBI | |
Barrett S, Collins M, Kenny C, Ryan E, Keane CO and Crowe J: Polymorphisms in tumour necrosis factor-alpha, transforming growth factor-beta, interleukin-10, interleukin-6, interferon-gamma, and outcome of hepatitis C virus infection. J Med Virol. 71:212–218. 2003. View Article : Google Scholar : PubMed/NCBI | |
Minton EJ, Smillie D, Smith P, Shipley S, McKendrick MW, Gleeson DC, Underwood JC, Cannings C and Wilson AG: Trent Hepatitis C Study Group: Clearance of hepatitis C virus is not associated with single nucleotide polymorphisms in the IL-1, −6, or −10 genes. Hum Immunol. 66:127–132. 2005. View Article : Google Scholar : PubMed/NCBI | |
Oleksyk TK, Thio CL, Truelove AL, Goedert JJ, Donfield SM, Kirk GD, Thomas DL, O'Brien SJ and Smith MW: Single nucleotide polymorphisms and haplotypes in the IL10 region associated with HCV clearance. Genes Immun. 6:347–357. 2005. View Article : Google Scholar : PubMed/NCBI | |
Paladino N, Fainboim H, Theiler G, Schroder T, Muñoz AE, Flores AC, Galdame O and Fainboim L: Gender susceptibility to chronic hepatitis C virus infection associated with interleukin 10 promoter polymorphism. J Virol. 80:9144–9150. 2006. View Article : Google Scholar : PubMed/NCBI | |
Lio D, Caruso C, Di Stefano R, Romano Colonna G, Ferraro D, Scola L, Crivello A, Licata A, Valenza LM, Candore G, et al: IL-10 and TNF-alpha polymorphisms and the recovery from HCV infection. Hum Immunol. 64:674–680. 2003. View Article : Google Scholar : PubMed/NCBI | |
Mangia A, Santoro R, Piattelli M, Pazienza V, Grifa G, Iacobellis A and Andriulli A: IL-10 haplotypes as possible predictors of spontaneous clearance of HCV infection. Cytokine. 25:103–109. 2004. View Article : Google Scholar : PubMed/NCBI | |
Kusumoto K, Uto H, Hayashi K, Takahama Y, Nakao H, Suruki R, Stuver SO, Ido A and Tsubouchi H: Interleukin-10 or tumor necrosis factor-alpha polymorphisms and the natural course of hepatitis C virus infection in a hyperendemic area of Japan. Cytokine. 34:24–31. 2006. View Article : Google Scholar : PubMed/NCBI | |
Houldsworth A, Metzner M, Rossol S, Shaw S, Kaminski E, Demaine AG and Cramp ME: Polymorphisms in the IL-12B gene and outcome of HCV infection. J Interferon Cytokine Res. 25:271–276. 2005. View Article : Google Scholar : PubMed/NCBI | |
Mueller T, Mas-Marques A, Sarrazin C, Wiese M, Halangk J, Witt H, Ahlenstiel G, Spengler U, Goebel U, Wiedenmann B, et al: Influence of interleukin 12B (IL12B) polymorphisms on spontaneous and treatment-induced recovery from hepatitis C virus infection. J Hepatol. 41:652–658. 2004. View Article : Google Scholar : PubMed/NCBI | |
Yin LM, Zhu WF, Wei L, Xu XY, Sun DG, Wang YB, Fan WM, Yu M, Tian XL, Wang QX, et al: Association of interleukin-12 p40 gene 3′-untranslated region polymorphism and outcome of HCV infection. World J Gastroenterol. 10:2330–2333. 2004. View Article : Google Scholar : PubMed/NCBI | |
An P, Thio CL, Kirk GD, Donfield S, Goedert JJ and Winkler CA: Regulatory polymorphisms in the interleukin-18 promoter are associated with hepatitis C virus clearance. J Infect Dis. 198:1159–1165. 2008. View Article : Google Scholar : PubMed/NCBI | |
Hennig BJ, Frodsham AJ, Hellier S, Knapp S, Yee LJ, Wright M, Zhang L, Thomas HC, Thursz M and Hill AV: Influence of IL-10RA and IL-22 polymorphisms on outcome of hepatitis C virus infection. Liver Int. 27:1134–1143. 2007. View Article : Google Scholar : PubMed/NCBI | |
Larrea E, Garcia N, Qian C, Civeira MP and Prieto J: Tumor necrosis factor alpha gene expression and the response to interferon in chronic hepatitis C. Hepatology. 23:210–217. 1996. View Article : Google Scholar : PubMed/NCBI | |
D'Alfonso S and Richiardi PM: A polymorphic variation in a putative regulation box of the TNFA promoter region. Immunogenetics. 39:150–154. 1994. View Article : Google Scholar : PubMed/NCBI | |
Wilson AG, de Vries N, Pociot F, di Giovine FS, van der Putte LB and Duff GW: An allelic polymorphism within the human tumor necrosis factor alpha promoter region is strongly associated with HLA A1, B8, and DR3 alleles. J Exp Med. 177:557–560. 1993. View Article : Google Scholar : PubMed/NCBI | |
Wilson AG, Symons JA, McDowell TL, McDevitt HO and Duff GW: Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation. Proc Natl Acad Sci USA. 94:3195–3199. 1997. View Article : Google Scholar : PubMed/NCBI | |
Hohler T, Kruger A, Gerken G, Schneider PM, zum Büschenefelde Meyer KH and Rittner C: A tumor necrosis factor-alpha (TNF-alpha) promoter polymorphism is associated with chronic hepatitis B infection. Clin Exp Immunol. 111:579–582. 1998. View Article : Google Scholar : PubMed/NCBI | |
Dai CY, Chuang WL, Chang WY, Chen SC, Lee LP, Hsieh MY, Hou NJ, Lin ZY, Huang JF, Hsieh MY, et al: Tumor necrosis factor- alpha promoter polymorphism at position −308 predicts response to combination therapy in hepatitis C virus infection. J Infect Dis. 193:98–101. 2006. View Article : Google Scholar : PubMed/NCBI | |
Yee LJ, Tang J, Herrera J, Kaslow RA and van Leeuwen DJ: Tumor necrosis factor gene polymorphisms in patients with cirrhosis from chronic hepatitis C virus infection. Genes Immun. 1:386–390. 2000. View Article : Google Scholar : PubMed/NCBI | |
Schiemann U, Glas J, Török P, Simperl C, Martin K, König A, Schmidt F, Schaefer M and Folwaczny C: Response to combination therapy with interferon alfa-2a and ribavirin in chronic hepatitis C according to a TNF-alpha promoter polymorphism. Digestion. 68:1–4. 2003. View Article : Google Scholar : PubMed/NCBI | |
Kimura T, Saito T, Yoshimura M, Yixuan S, Baba M, Ji G, Muramatsu M and Kawata S: Association of transforming growth factor-beta 1 functional polymorphisms with natural clearance of hepatitis C virus. J Infect Dis. 193:1371–1374. 2006. View Article : Google Scholar : PubMed/NCBI | |
Neumann-Haefelin C, Blum HE, Chisari FV and Thimme R: T cell response in hepatitis C virus infection. J Clin Virol. 32:75–85. 2005. View Article : Google Scholar : PubMed/NCBI | |
Singh R, Kaul R, Kaul A and Khan K: A comparative review of HLA associations with hepatitis B and C viral infections across global populations. World J Gastroenterol. 13:1770–1787. 2007. View Article : Google Scholar : PubMed/NCBI | |
Alric L, Fort M, Izopet J, Vinel JP, Bureau C, Sandre K, Charlet JP, Beraud M, Abbal M and Duffaut M: Study of host- and virus-related factors associated with spontaneous hepatitis C virus clearance. Tissue Antigens. 56:154–158. 2000. View Article : Google Scholar : PubMed/NCBI | |
Thursz M, Yallop R, Goldin R, Trepo C and Thomas HC: Influence of MHC class II genotype on outcome of infection with hepatitis C virus. The HENCORE group. Hepatitis C European network for cooperative research. Lancet. 354:2119–2124. 1999. View Article : Google Scholar : PubMed/NCBI | |
McKiernan SM, Hagan R, Curry M, McDonald GS, Kelly A, Nolan N, Walsh A, Hegarty J, Lawlor E and Kelleher D: Distinct MHC class I and II alleles are associated with hepatitis C viral clearance, originating from a single source. Hepatology. 40:108–114. 2004. View Article : Google Scholar : PubMed/NCBI | |
Chuang WC, Sarkodie F, Brown CJ, Owusu-Ofori S, Brown J, Li C, Navarrete C, Klenerman P and Allain JP: Protective effect of HLA-B57 on HCV genotype 2 infection in a West African population. J Med Virol. 79:724–733. 2007. View Article : Google Scholar : PubMed/NCBI | |
Thio CL, Gao X, Goedert JJ, Vlahov D, Nelson KE, Hilgartner MW, O'Brien SJ, Karacki P, Astemborski J, Carrington M and Thomas DL: HLA-Cw*04 and hepatitis C virus persistence. J Virol. 76:4792–4797. 2002. View Article : Google Scholar : PubMed/NCBI | |
Hraber P, Kuiken C and Yusim K: Evidence for human leukocyte antigen heterozygote advantage against hepatitis C virus infection. Hepatology. 46:1713–1721. 2007. View Article : Google Scholar : PubMed/NCBI | |
Hong X, Yu RB, Sun NX, Wang B, Xu YC and Wu GL: Human leukocyte antigen class II DQB1*0301, DRB1*1101 alleles and spontaneous clearance of hepatitis C virus infection: A meta-analysis. World J Gastroenterol. 11:7302–7307. 2005. View Article : Google Scholar : PubMed/NCBI | |
Schmidt J, Thimme R and Neumann-Haefelin C: Host genetics in immune-mediated hepatitis C virus clearance. Biomark Med. 5:155–169. 2011. View Article : Google Scholar : PubMed/NCBI | |
Khakoo SI, Thio CL, Martin MP, Brooks CR, Gao X, Astemborski J, Cheng J, Goedert JJ, Vlahov D, Hilgartner M, et al: HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection. Science. 305:872–874. 2004. View Article : Google Scholar : PubMed/NCBI | |
Zúñiga J, Romero V, Azocar J, Terreros D, Vargas- MI, Torres-García D, Jiménez-Alvarez L, Vargas-Alarcón G, Granados-Montiel J, Husain Z, et al: Protective KIR-HLA interactions for HCV infection in intravenous drug users. Mol Immunol. 46:2723–2727. 2009. View Article : Google Scholar : PubMed/NCBI | |
Lu Z, Zhang B, Chen S, Gai Z, Feng Z, Liu X, Liu Y, Wen X, Li L, Jiao Y, et al: Association of KIR genotypes and haplotypes with susceptibility to chronic hepatitis B virus infection in Chinese Han population. Cell Mol Immunol. 5:457–463. 2008. View Article : Google Scholar : PubMed/NCBI | |
Dring MM, Morrison MH, McSharry BP, Guinan KJ and Hagan R: Irish HCV Research Consortium, O'Farrelly C and Gardiner CM: Innate immune genes synergize to predict increased risk of chronic disease in hepatitis C virus infection. Proc Natl Acad Sci USA. 108:5736–5741. 2011. View Article : Google Scholar : PubMed/NCBI | |
Knapp S, Warshow U, Hegazy D, Brackenbury L, Guha IN, Fowell A, Little AM, Alexander GJ, Rosenberg WM, Cramp ME and Khakoo SI: Consistent beneficial effects of killer cell immunoglobulin-like receptor 2DL3 and group 1 human leukocyte antigen-C following exposure to hepatitis C virus. Hepatology. 51:1168–1175. 2010. View Article : Google Scholar : PubMed/NCBI | |
Romero V, Azocar J, Zúñiga J, Clavijo OP, Terreros D, Gu X, Husain Z, Chung RT, Amos C and Yunis EJ: Interaction of NK inhibitory receptor genes with HLA-C and MHC class II alleles in Hepatitis C virus infection outcome. Mol Immunol. 45:2429–2436. 2008. View Article : Google Scholar : PubMed/NCBI | |
Montes-Cano MA, Caro-Oleas JL, Romero-Gómez M, Diago M, Andrade R, Carmona I, Reina Aguilar J, Núñez-Roldán A and González-Escribano MF: HLA-C and KIR genes in hepatitis C virus infection. Hum Immunol. 66:1106–1109. 2005. View Article : Google Scholar : PubMed/NCBI | |
Rauch A, Laird R, McKinnon E, Telenti A, Furrer H, Weber R, Smillie D and Gaudieri S: Swiss HIV Cohort Study: Influence of inhibitory killer immunoglobulin-like receptors and their HLA-C ligands on resolving hepatitis C virus infection. Tissue Antigens. 69:(Suppl 1). S237–S240. 2007. View Article : Google Scholar | |
Schott E, Witt H, Hinrichsen H, Neumann K, Weich V, Bergk A, Halangk J, Müller T, Tinjala S, Puhl G, Neuhaus P, et al: Gender-dependent association of CTLA4 polymorphisms with resolution of hepatitis C virus infection. J Hepatol. 46:372–380. 2007. View Article : Google Scholar : PubMed/NCBI | |
Zhu C, Zhang R, Liu D, Mukhtar MM, Liu W, Peng G, Wang K, Hao Q, Xu Y, Liu F, et al: Association of functional polymorphism of ApoB promoter with hepatitis C virus infection. Clin Chim Acta. 401:124–127. 2009. View Article : Google Scholar : PubMed/NCBI | |
Sarrazin C, Berg T, Ross RS, Schirmacher P, Wedemeyer H, Neumann U, Schmidt HH, Spengler U, Wirth S, Kessler HH, et al: Prophylaxis, diagnosis and therapy of hepatitis C virus (HCV) infection: The German guidelines on the management of HCV infection. Z Gastroenterol. 48:289–351. 2010.(In German). View Article : Google Scholar : PubMed/NCBI | |
Ge D, Fellay J, Thompson AJ, Simon JS, Shianna KV, Urban TJ, Heinzen EL, Qiu P, Bertelsen AH, Muir AJ, et al: Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature. 461:399–401. 2009. View Article : Google Scholar : PubMed/NCBI | |
Suppiah V, Moldovan M, Ahlenstiel G, Berg T, Weltman M, Abate ML, Bassendine M, Spengler U, Dore GJ, Powell E, et al: IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy. Nat Genet. 41:1100–1104. 2009. View Article : Google Scholar : PubMed/NCBI | |
Tanaka Y, Nishida N, Sugiyama M, Kurosaki M, Matsuura K, Sakamoto N, Nakagawa M, Korenaga M, Hino K, Hige S, et al: Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C. Nat Genet. 41:1105–1109. 2009. View Article : Google Scholar : PubMed/NCBI | |
Antaki N, Bibert S, Kebbewar K, Asaad F, Baroudi O, Alideeb S, Hadad M, Abboud D, Sabah H, Bochud PY and Negro F: IL28B polymorphisms predict response to therapy among chronic hepatitis C patients with HCV genotype 4. J Viral Hepat. 20:59–64. 2013. View Article : Google Scholar : PubMed/NCBI | |
Rallon NI, Naggie S, Benito JM, Medrano J, Restrepo C, Goldstein D, Shianna KV, Vispo E, Thompson A, McHutchison J and Soriano V: Association of a single nucleotide polymorphism near the interleukin-28B gene with response to hepatitis C therapy in HIV/hepatitis C virus-coinfected patients. AIDS. 24:F23–F29. 2010. View Article : Google Scholar : PubMed/NCBI | |
Thompson AJ, Muir AJ, Sulkowski MS, Ge D, Fellay J, Shianna KV, Urban T, Afdhal NH, Jacobson IM, Esteban R, et al: Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus. Gastroenterology. 139:120–129, e18. 2010. View Article : Google Scholar : PubMed/NCBI | |
Bochud PY, Bibert S, Negro F, Haagmans B, Soulier A, Ferrari C, Missale G, Zeuzem S, Pawlotsky JM, Schalm S, et al: IL28B polymorphisms predict reduction of HCV RNA from the first day of therapy in chronic hepatitis C. J Hepatol. 55:980–988. 2011. View Article : Google Scholar : PubMed/NCBI | |
Scherzer TM, Hofer H, Staettermayer AF, Rutter K, Beinhardt S, Steindl-Munda P, Kerschner H, Kessler HH and Ferenci P: Early virologic response and IL28B polymorphisms in patients with chronic hepatitis C genotype 3 treated with peginterferon alfa-2a and ribavirin. J Hepatol. 54:866–871. 2011. View Article : Google Scholar : PubMed/NCBI | |
Yu ML, Huang CF, Huang JF, Chang NC, Yang JF, Lin ZY, Chen SC, Hsieh MY, Wang LY, Chang WY, et al: Role of interleukin-28B polymorphisms in the treatment of hepatitis C virus genotype 2 infection in Asian patients. Hepatology. 53:7–13. 2011. View Article : Google Scholar : PubMed/NCBI | |
Stättermayer AF, Stauber R, Hofer H, Rutter K, Beinhardt S, Scherzer TM, Zinober K, Datz C, Maieron A, Dulic-Lakovic E, et al: Impact of IL28B genotype on the early and sustained virologic response in treatment-naïve patients with chronic hepatitis C. Clin Gastroenterol Hepatol. 9:344–350, e2. 2011. View Article : Google Scholar : PubMed/NCBI | |
Jaeckel E, Cornberg M, Wedemeyer H, Santantonio T, Mayer J, Zankel M, Pastore G, Dietrich M, Trautwein C and Manns MP: German Acute Hepatitis C Therapy Group: Treatment of acute hepatitis C with interferon alfa-2b. N Engl J Med. 345:1452–1457. 2001. View Article : Google Scholar : PubMed/NCBI | |
Wiegand J, Buggisch P, Boecher W, Zeuzem S, Gelbmann CM, Berg T, Kauffmann W, Kallinowski B, Cornberg M and Jaeckel E: Early monotherapy with pegylated interferon alpha-2b for acute hepatitis C infection: The HEP-NET acute-HCV-II study. Hepatology. 43:250–256. 2006. View Article : Google Scholar : PubMed/NCBI | |
Kamal SM, Fouly AE, Kamel RR, Hockenjos B, Al Tawil A, Khalifa KE, He Q, Koziel MJ, El Naggar KM, Rasenack J and Afdhal NH: Peginterferon alfa-2b therapy in acute hepatitis C: Impact of onset of therapy on sustained virologic response. Gastroenterology. 130:632–638. 2006. View Article : Google Scholar : PubMed/NCBI | |
Holmes JA, Sievert W and Thompson AJ: IL28B polymorphism and genetic biomarkers of viral clearance in hepatitis C virus infection. Biomark Med. 5:461–478. 2011. View Article : Google Scholar : PubMed/NCBI | |
Halfon P, Bourliere M, Ouzan D, Maor Y, Renou C, Wartelle C, Pénaranda G, Tran A, Botta D, Oules V, et al: A single IL28B genotype SNP rs12979860 determination predicts treatment response in patients with chronic hepatitis C Genotype 1 virus. Eur J Gastroenterol Hepatol. 23:931–935. 2011. View Article : Google Scholar : PubMed/NCBI | |
Ghany MG, Nelson DR, Strader DB, Thomas DL and Seeff LB: American Association for Study of Liver Diseases: An update on treatment of genotype 1 chronic hepatitis C virus infection: 2011 practice guideline by the American Association for the study of liver diseases. Hepatology. 54:1433–1444. 2011. View Article : Google Scholar : PubMed/NCBI | |
Ank N, Iversen MB, Bartholdy C, Staeheli P, Hartmann R, Jensen UB, Dagnaes-Hansen F, Thomsen AR, Chen Z, Haugen H, et al: An important role for type III interferon (IFN-lambda/IL-28) in TLR-induced antiviral activity. J Immunol. 180:2474–2485. 2008. View Article : Google Scholar : PubMed/NCBI | |
Li M, Liu X, Zhou Y and Su SB: Interferon-lambdas: The modulators of antivirus, antitumor, and immune responses. J Leukoc Biol. 86:23–32. 2009. View Article : Google Scholar : PubMed/NCBI | |
Honda M, Sakai A, Yamashita T, Nakamoto Y, Mizukoshi E, Sakai Y, Yamashita T, Nakamura M, Shirasaki T, Horimoto K, et al: Hepatic ISG expression is associated with genetic variation in interleukin 28B and the outcome of IFN therapy for chronic hepatitis C. Gastroenterology. 139:499–509. 2010. View Article : Google Scholar : PubMed/NCBI | |
Urban TJ, Thompson AJ, Bradrick SS, Fellay J, Schuppan D, Cronin KD, Hong L, McKenzie A, Patel K, Shianna KV, et al: IL28B genotype is associated with differential expression of intrahepatic interferon-stimulated genes in patients with chronic hepatitis C. Hepatology. 52:1888–1896. 2010. View Article : Google Scholar : PubMed/NCBI | |
Jacobson IM, Catlett I, Marcellin P, Bzowej NH, Muir AJ, Adda N, Bengtsson L, George S, Seepersaud S, Ramachandram R, et al: 1369 Telaprevir substantially improved SVR rates across all IL28B genotypes in the advance trial. J Hepatology. 54:S542–S543. 2011. View Article : Google Scholar | |
Bronowicki JP, Hezode C, Bengtsson L, Pol S, Bourliere M, Serfaty L, de Ledinghen V, Tran A, Benhamou Y, Grang JD, et al: 1094 100% SVR in IL28B CC patients treated with 12 weeks of telaprevir, peginterferon and ribavirin in the PROVE2 trial. J Hepatology. 56:S430–S431. 2012. View Article : Google Scholar | |
Penney MS, De Souza C, Seepersaud S, Alves K, Koziel MJ, Kauffman RS, Di Bisceglie AM and Botfield MC: 1203 All IL28B genotypes have high SVR rates in patients treated with VX-222 in combination with Telaprevir/Peginterferon/Ribavin in the ZENITH study. J Hepatology. 56:S476–S477. 2012. View Article : Google Scholar | |
Poordad F, Bronowicki JP, Gordon SC, Zeuzem S, Jacobson IM, Sulkowski MS, Poynard TMorgan, TRBurroughs MSniukiene V, et al: 12 IL28B polymorphism predicts virologic response in patients with hepatitis C genotype 1 treated with boceprevir (BOC) combination therapy. J Hepatology. 54:S62011. View Article : Google Scholar | |
Sulkowski MS, Asselah T, Lalezari J, Ferenci P, Fainboim H, Leggett B, Bessone F, Mauss S, Heo J, Datsenko Y, et al: Faldaprevir combined with pegylated interferon alfa-2a and ribavirin in treatment-naïve patients with chronic genotype 1 HCV: SILEN-C1 trial. Hepatology. 57:2143–2154. 2013. View Article : Google Scholar : PubMed/NCBI | |
Chu TW, Kulkarni R, Gane EJ, Roberts SK, Stedman C, Angus PW, Ritchie B, Lu XY, Ipe D, Lopatin U, et al: Effect of IL28B genotype on early viral kinetics during interferon-free treatment of patients with chronic hepatitis C. Gastroenterology. 142:790–795. 2012. View Article : Google Scholar : PubMed/NCBI | |
Liu S, Cipriano LE, Holodniy M, Owens DK and Goldhaber-Fiebert JD: New protease inhibitors for the treatment of chronic hepatitis C: A cost-effectiveness analysis. Ann Intern Med. 156:279–290. 2012. View Article : Google Scholar : PubMed/NCBI | |
Hijikata M, Ohta Y and Mishiro S: Identification of a single nucleotide polymorphism in the MxA gene promoter (G/T at nt −88) correlated with the response of hepatitis C patients to interferon. Intervirology. 43:124–127. 2000. View Article : Google Scholar : PubMed/NCBI | |
Knapp S, Yee LJ, Frodsham AJ, Hennig BJ, Hellier S, Zhang L, Wright M, Chiaramonte M, Graves M, Thomas HC, et al: Polymorphisms in interferon-induced genes and the outcome of hepatitis C virus infection: Roles of MxA, OAS-1 and PKR. Genes Immun. 4:411–419. 2003. View Article : Google Scholar : PubMed/NCBI | |
Suzuki F, Arase Y, Suzuki Y, Tsubota A, Akuta N, Hosaka T, Someya T, Kobayashi M, Saitoh S, Ikeda K, et al: Single nucleotide polymorphism of the MxA gene promoter influences the response to interferon monotherapy in patients with hepatitis C viral infection. J Viral Hepat. 11:271–276. 2004. View Article : Google Scholar : PubMed/NCBI | |
El Bader Din NG, Salum GM, Anany MA, Ibrahim MK, Dawood RM, Zayed N, El Abd YS, El-Shenawy R and El Awady MK: Association of myxovirus resistance gene promoter polymorphism with response to combined interferon treatment and progression of liver disease in chronic HCV egyptian patients. J Interferon Cytokine Res. 35:641–648. 2015. View Article : Google Scholar : PubMed/NCBI | |
Persico M, Capasso M, Russo R, Persico E, Crocè L, Tiribelli C and Iolascon A: Elevated expression and polymorphisms of SOCS3 influence patient response to antiviral therapy in chronic hepatitis C. Gut. 57:507–515. 2008. View Article : Google Scholar : PubMed/NCBI | |
Welzel TM, Morgan TR, Bonkovsky HL, Naishadham D, Pfeiffer RM, Wright EC, Hutchinson AA, Crenshaw AT, Bashirova A, Carrington M, et al: Variants in interferon-alpha pathway genes and response to pegylated interferon-Alpha2a plus ribavirin for treatment of chronic hepatitis C virus infection in the hepatitis C antiviral long-term treatment against cirrhosis trial. Hepatology. 49:1847–1858. 2009. View Article : Google Scholar : PubMed/NCBI | |
Su X, Yee LJ, Im K, Rhodes SL, Tang Y, Tong X, Howell C, Ramcharran D, Rosen HR, Taylor MW, et al: Association of single nucleotide polymorphisms in interferon signaling pathway genes and interferon-stimulated genes with the response to interferon therapy for chronic hepatitis C. J Hepatol. 49:184–191. 2008. View Article : Google Scholar : PubMed/NCBI | |
Constantini PK, Wawrzynowicz-Syczewska M, Clare M, Boron-Kaczmarska A, McFarlane IG, Cramp ME and Donaldson PT: Interleukin-1, interleukin-10 and tumour necrosis factor-alpha gene polymorphisms in hepatitis C virus infection: An investigation of the relationships with spontaneous viral clearance and response to alpha-interferon therapy. Liver. 22:404–412. 2002. View Article : Google Scholar : PubMed/NCBI | |
Edwards-Smith CJ, Jonsson JR, Purdie DM, Bansal A, Shorthouse C and Powell EE: Interleukin-10 promoter polymorphism predicts initial response of chronic hepatitis C to interferon alfa. Hepatology. 30:526–530. 1999. View Article : Google Scholar : PubMed/NCBI | |
Vidigal PG, Germer JJ and Zein NN: Polymorphisms in the interleukin-10, tumor necrosis factor-alpha and transforming growth factor-beta1 genes in chronic hepatitis C patients treated with interferon and ribavirin. J Hepatol. 36:271–277. 2002. View Article : Google Scholar : PubMed/NCBI | |
Gracie JA, Robertson SE and McInnes IB: Interleukin-18. J Leukoc Biol. 73:213–224. 2003. View Article : Google Scholar : PubMed/NCBI | |
Nakanishi K, Yoshimoto T, Tsutsui H and Okamura H: Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu. Cytokine Growth Factor Rev. 12:53–72. 2001. View Article : Google Scholar : PubMed/NCBI | |
Tsutsui H, Adachi K, Seki E and Nakanishi K: Cytokine-induced inflammatory liver injuries. Curr Mol Med. 3:545–559. 2003. View Article : Google Scholar : PubMed/NCBI | |
Haas SL, Weiss C, Bugert P, Gundt J, Witt H, Singer MV, Berg T and Böcker U: Interleukin 18 promoter variants (−137G>C and −607C>A) in patients with chronic hepatitis C: Association with treatment response. J Clin Immunol. 29:620–628. 2009. View Article : Google Scholar : PubMed/NCBI | |
Giedraitis V, He B, Huang WX and Hillert J: Cloning and mutation analysis of the human IL-18 promoter: A possible role of polymorphisms in expression regulation. J Neuroimmunol. 112:146–152. 2001. View Article : Google Scholar : PubMed/NCBI | |
Rosen HR, McHutchison JG, Conrad AJ, Lentz JJ, Marousek G, Rose SL, Zaman A, Taylor K and Chou S: Tumor necrosis factor genetic polymorphisms and response to antiviral therapy in patients with chronic hepatitis C. Am J Gastroenterol. 97:714–720. 2002. View Article : Google Scholar : PubMed/NCBI | |
Neuman MG, Benhamou JP, Martinot M, Boyer N, Shear NH, Malkiewicz I, Katz GG, Suneja A, Singh S and Marcellin P: Predictors of sustained response to alpha interferon therapy in chronic hepatitis C. Clin Biochem. 32:537–545. 1999. View Article : Google Scholar : PubMed/NCBI | |
Wasmuth HE, Werth A, Mueller T, Berg T, Dietrich CG, Geier A, Gartung C, Lorenzen J, Matern S and Lammert F: Haplotype-tagging RANTES gene variants influence response to antiviral therapy in chronic hepatitis C. Hepatology. 40:327–334. 2004. View Article : Google Scholar : PubMed/NCBI | |
Huang Y, Yang H, Borg BB, Su X, Rhodes SL, Yang K, Tong X, Tang G, Howell CD, Rosen HR, et al: A functional SNP of interferon-gamma gene is important for interferon-alpha-induced and spontaneous recovery from hepatitis C virus infection. Proc Natl Acad Sci USA. 104:985–990. 2007. View Article : Google Scholar : PubMed/NCBI | |
Almarri A, El Dwick N, Al Kabi S, Sleem K, Rashed A, Ritter MA and Batchelor JR: Interferon-alpha therapy in HCV hepatitis: HLA phenotype and cirrhosis are independent predictors of clinical outcome. Hum Immunol. 59:239–242. 1998. View Article : Google Scholar : PubMed/NCBI | |
Romero-Gomez M, González-Escribano MF, Torres B, Barroso N, Montes-Cano MA, Sánchez-Muñoz D, Núñez-Roldan A and Aguilar-Reina J: HLA class I B44 is associated with sustained response to interferon + ribavirin therapy in patients with chronic hepatitis C. Am J Gastroenterol. 98:1621–1626. 2003. View Article : Google Scholar : PubMed/NCBI | |
Jiao J and Wang JB: Hepatitis C virus genotypes, HLA-DRB alleles and their response to interferon-alpha and ribavirin in patients with chronic hepatitis C. Hepatobiliary Pancreat Dis Int. 4:80–83. 2005.PubMed/NCBI | |
Lindemann M, Virchow S, Ramann F, Barsegian V, Kreuzfelder E, Siffert W, Müller N and Grosse-Wilde H: The G protein beta3 subunit 825T allele is a genetic marker for enhanced T cell response. FEBS Lett. 495:82–86. 2001. View Article : Google Scholar : PubMed/NCBI | |
Sarrazin C, Berg T, Weich V, Mueller T, Frey UH, Zeuzem S, Gerken G, Roggendorf M and Siffert W: GNB3 C825T polymorphism and response to interferon-alfa/ribavirin treatment in patients with hepatitis C virus genotype 1 (HCV-1) infection. J Hepatol. 43:388–393. 2005. View Article : Google Scholar : PubMed/NCBI | |
Ahlenstiel G, Nischalke HD, Bueren K, Berg T, Vogel M, Biermer M, Grünhage F, Sauerbruch T, Rockstroh J, Spengler U and Nattermann J: The GNB3 C825T polymorphism affects response to HCV therapy with pegylated interferon in HCV/HIV co-infected but not in HCV mono-infected patients. J Hepatol. 47:348–355. 2007. View Article : Google Scholar : PubMed/NCBI | |
Schott E, Witt H, Neumann K, Bergk A, Halangk J, Weich V, Müller T, Puhl G, Wiedenmann B and Berg T: Association of TLR7 single nucleotide polymorphisms with chronic HCV-infection and response to interferon-a-based therapy. J Viral Hepat. 15:71–78. 2008.PubMed/NCBI | |
Lebray P, Zylberberg H, Hue S, Poulet B, Carnot F, Martin S, Chretien Y, Pol S, Caillat-Zuckman S, Bréchot C and Nalpas B: Influence of HFE gene polymorphism on the progression and treatment of chronic hepatitis C. J Viral Hepat. 11:175–182. 2004. View Article : Google Scholar : PubMed/NCBI | |
Yee LJ, Perez KA, Tang J, van Leeuwen DJ and Kaslow RA: Association of CTLA4 polymorphisms with sustained response to interferon and ribavirin therapy for chronic hepatitis C virus infection. J Infect Dis. 187:1264–1271. 2003. View Article : Google Scholar : PubMed/NCBI | |
Patton HM, Patel K, Behling C, Bylund D, Blatt LM, Vallée M, Heaton S, Conrad A, Pockros PJ and McHutchison JG: The impact of steatosis on disease progression and early and sustained treatment response in chronic hepatitis C patients. J Hepatol. 40:484–490. 2004. View Article : Google Scholar : PubMed/NCBI | |
Westin J, Lagging M, Dhillon AP, Norkrans G, Romero AI, Pawlotsky JM, Zeuzem S, Schalm SW, Verheij-Hart E, Negro F, et al: Impact of hepatic steatosis on viral kinetics and treatment outcome during antiviral treatment of chronic HCV infection. J Viral Hepat. 14:29–35. 2007. View Article : Google Scholar : PubMed/NCBI | |
Shah SR, Patel K, Marcellin P, Foster GR, Manns M, Kottilil S, Healey L, Pulkstenis E, Subramanian GM, McHutchison JG, et al: Steatosis is an independent predictor of relapse following rapid virologic response in patients with HCV genotype 3. Clin Gastroenterol Hepatol. 9:688–693. 2011. View Article : Google Scholar : PubMed/NCBI | |
Restivo L, Zampino R, Guerrera B, Ruggiero L and Adinolfi LE: Steatosis is the predictor of relapse in HCV genotype 3- but not 2-infected patients treated with 12 weeks of pegylated interferon-α-2a plus ribavirin and RVR. J Viral Hepat. 19:346–352. 2012. View Article : Google Scholar : PubMed/NCBI | |
Conjeevaram HS, Kleiner DE, Everhart JE, Hoofnagle JH, Zacks S, Afdhal NH and Wahed AS: Virahep-C Study Group: Race, insulin resistance and hepatic steatosis in chronic hepatitis C. Hepatology. 45:80–87. 2007. View Article : Google Scholar : PubMed/NCBI | |
Tarantino G, Conca P, Sorrentino P and Ariello M: Metabolic factors involved in the therapeutic response of patients with hepatitis C virus-related chronic hepatitis. J Gastroenterol Hepatol. 21:1266–1268. 2006. View Article : Google Scholar : PubMed/NCBI | |
Hanouneh IA, Feldstein AE, Lopez R, Yerian L, Pillai A, Zein CO and Zein NN: Clinical significance of metabolic syndrome in the setting of chronic hepatitis C virus infection. Clin Gastroenterol Hepatol. 6:584–589. 2008. View Article : Google Scholar : PubMed/NCBI | |
Shirakawa H, Matsumoto A, Joshita S, Komatsu M, Tanaka N, Umemura T, Ichijo T, Yoshizawa K, Kiyosawa K and Tanaka E: Nagano Interferon Treatment Research Group: Pretreatment prediction of virological response to peginterferon plus ribavirin therapy in chronic hepatitis C patients using viral and host factors. Hepatology. 48:1753–1760. 2008. View Article : Google Scholar : PubMed/NCBI | |
Zeuzem S: Heterogeneous virologic response rates to interferon-based therapy in patients with chronic hepatitis C: Who responds less well? Ann Intern Med. 140:370–381. 2004.PubMed/NCBI | |
Fellay J, Thompson AJ, Ge D, Gumbs CE, Urban TJ, Shianna KV, Little LD, Qiu P, Bertelsen AH, Watson M, et al: ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C. Nature. 464:405–408. 2010. View Article : Google Scholar : PubMed/NCBI | |
Thompson AJ, Clark PJ, Singh A, Ge D, Fellay J, Zhu M, Zhu Q, Urban TJ, Patel K, Tillmann HL, et al: Genome-wide association study of interferon-related cytopenia in chronic hepatitis C patients. J Hepatol. 56:313–319. 2012. View Article : Google Scholar : PubMed/NCBI | |
Thompson AJ, Fellay J, Patel K, Tillmann HL, Naggie S, Ge D, Urban TJ, Shianna KV, Muir AJ, Fried MW, et al: Variants in the ITPA gene protect against ribavirin-induced hemolytic anemia and decrease the need for ribavirin dose reduction. Gastroenterology. 139:1181–1189. 2010. View Article : Google Scholar : PubMed/NCBI | |
Thompson AJ, Santoro R, Piazzolla V, Clark PJ, Naggie S, Tillmann HL, Patel K, Muir AJ, Shianna KV, Mottola L, et al: Inosine triphosphatase genetic variants are protective against anemia during antiviral therapy for HCV2/3 but do not decrease dose reductions of RBV or increase SVR. Hepatology. 53:389–395. 2011. View Article : Google Scholar : PubMed/NCBI | |
Hitomi Y, Cirulli ET, Fellay J, McHutchison JG, Thompson AJ, Gumbs CE, Shianna KV, Urban TJ and Goldstein DB: Inosine triphosphate protects against ribavirin-induced adenosine triphosphate loss by adenylosuccinate synthase function. Gastroenterology. 140:1314–1321. 2011. View Article : Google Scholar : PubMed/NCBI | |
Gochee PA, Powell EE, Purdie DM, Pandeya N, Kelemen L, Shorthouse C, Jonsson JR and Kelly B: Association between apolipoprotein E epsilon4 and neuropsychiatric symptoms during interferon alpha treatment for chronic hepatitis C. Psychosomatics. 45:49–57. 2004. View Article : Google Scholar : PubMed/NCBI | |
Horsburgh K, McCarron MO, White F and Nicoll JA: The role of apolipoprotein E in Alzheimer's disease, acute brain injury and cerebrovascular disease: Evidence of common mechanisms and utility of animal models. Neurobiol Aging. 21:245–255. 2000. View Article : Google Scholar : PubMed/NCBI | |
Wada M, Marusawa H, Yamada R, Nasu A, Osaki Y, Kudo M, Nabeshima M, Fukuda Y, Chiba T and Matsuda F: Association of genetic polymorphisms with interferon-induced haematologic adverse effects in chronic hepatitis C patients. J Viral Hepat. 16:388–396. 2009. View Article : Google Scholar : PubMed/NCBI | |
Poynard T, Bedossa P and Opolon P: Natural history of liver fibrosis progression in patients with chronic hepatitis C. The OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC groups. Lancet. 349:825–832. 1997. View Article : Google Scholar : PubMed/NCBI | |
Thomas DL, Astemborski J, Rai RM, Anania FA, Schaeffer M, Galai N, Nolt K, Nelson KE, Strathdee SA, Johnson L, et al: The natural history of hepatitis C virus infection: Host, viral, and environmental factors. JAMA. 284:450–456. 2000. View Article : Google Scholar : PubMed/NCBI | |
Davis GL, Alter MJ, El-Serag H, Poynard T and Jennings LW: Aging of hepatitis C virus (HCV)-infected persons in the United States: A multiple cohort model of HCV prevalence and disease progression. Gastroenterology. 138:513–521. 2010. View Article : Google Scholar : PubMed/NCBI | |
Missiha SB, Ostrowski M and Heathcote EJ: Disease progression in chronic hepatitis C: Modifiable and nonmodifiable factors. Gastroenterology. 134:1699–1714. 2008. View Article : Google Scholar : PubMed/NCBI | |
Wright M, Goldin R, Fabre A, Lloyd J, Thomas H, Trepo C, Pradat P and Thursz M: HENCORE collaboration: Measurement and determinants of the natural history of liver fibrosis in hepatitis C virus infection: A cross sectional and longitudinal study. Gut. 52:574–579. 2003. View Article : Google Scholar : PubMed/NCBI | |
Bataller R, North KE and Brenner DA: Genetic polymorphisms and the progression of liver fibrosis: A critical appraisal. Hepatology. 37:493–503. 2003. View Article : Google Scholar : PubMed/NCBI | |
Huang H, Shiffman ML, Friedman S, Venkatesh R, Bzowej N, Abar OT, Rowland CM, Catanese JJ, Leong DU, Sninsky JJ, et al: A 7 gene signature identifies the risk of developing cirrhosis in patients with chronic hepatitis C. Hepatology. 46:297–306. 2007. View Article : Google Scholar : PubMed/NCBI | |
Marcolongo M, Young B, Dal Pero F, Fattovich G, Peraro L, Guido M, Sebastiani G, Palù G and Alberti A: A seven-gene signature (cirrhosis risk score) predicts liver fibrosis progression in patients with initially mild chronic hepatitis C. Hepatology. 50:1038–1044. 2009. View Article : Google Scholar : PubMed/NCBI | |
Trepo E, Potthoff A, Pradat P, Bakshi R, Young B, Lagier R, Moreno C, Verset L, Cross R, Degré D, et al: Role of a cirrhosis risk score for the early prediction of fibrosis progression in hepatitis C patients with minimal liver disease. J Hepatol. 55:38–44. 2011. View Article : Google Scholar : PubMed/NCBI | |
Thompson AJ, Clark PJ, Zhu M, Ge D, Sulkowski MS, Muir AJ, Tillmann HL, Patel K, Naggie S, Afdhal NH, et al: Genome wide-association study identifies IL28B polymorphism to be associated with baseline ALT and hepatic necro-inflammatory activity in chronic hepatitis C patients enrolled in the IDEAL study. Journal. 52:1220A–1221A. 2010. | |
Stickel F, Buch S, Lau K, zu Schwabedissen Meyer H, Berg T, Ridinger M, Rietschel M, Schafmayer C, Braun F, Hinrichsen H, et al: Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians. Hepatology. 53:86–95. 2011. View Article : Google Scholar : PubMed/NCBI | |
Trépo E, Pradat P, Potthoff A, Momozawa Y, Quertinmont E, Gustot T, Lemmers A, Berthillon P, Amininejad L, Chevallier M, et al: Impact of patatin-like phospholipase-3 (rs738409 C>G) polymorphism on fibrosis progression and steatosis in chronic hepatitis C. Hepatology. 54:60–69. 2011. View Article : Google Scholar : PubMed/NCBI | |
Dunn W, O'Neil M, Zhao J, Wu CH, Roberts B, Chakraborty S, Sherman C, Weaver B, Taylor R, Olson J, et al: Donor PNPLA3 rs738409 genotype affects fibrosis progression in liver transplantation for hepatitis C. Hepatology. 59:453–460. 2014. View Article : Google Scholar : PubMed/NCBI | |
Valenti L, Aghemo A, Stättermayer AF, Maggioni P, De Nicola S, Motta BM, Rumi MG, Dongiovanni P, Ferenci P, Colombo M and Fargion S: Implications of PNPLA3 polymorphism in chronic hepatitis C patients receiving peginterferon plus ribavirin. Aliment Pharmacol Ther. 35:1434–1442. 2012. View Article : Google Scholar : PubMed/NCBI | |
Nakamura M, Kanda T, Nakamoto S, Miyamura T, Jiang X, Wu S and Yokosuka O: No correlation between PNPLA3 rs738409 genotype and fatty liver and hepatic cirrhosis in Japanese patients with HCV. PLoS One. 8:e813122013. View Article : Google Scholar : PubMed/NCBI | |
Patin E, Kutalik Z, Guergnon J, Bibert S, Nalpas B, Jouanguy E, Munteanu M, Bousquet L, Argiro L, Halfon P, et al: Genome-wide association study identifies variants associated with progression of liver fibrosis from HCV infection. Gastroenterology. 143:1244–1252, e1-12. 2012. View Article : Google Scholar : PubMed/NCBI |