Wnt/β-catenin signaling pathway in trophoblasts and abnormal activation in preeclampsia (Review)

Zhang,Zhan; Wang,Xiaofang; Zhang,Linlin; Shi,Ying; Wang,Jinming; Yan,Huan

doi:10.3892/mmr.2017.6718

Wnt/β-catenin signaling pathway in trophoblasts and abnormal activation in preeclampsia (Review)

Authors:
- Zhan Zhang
- Xiaofang Wang
- Linlin Zhang
- Ying Shi
- Jinming Wang
- Huan Yan
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Affiliations: Department of Clinical Laboratory, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China, Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
Published online on: June 7, 2017 https://doi.org/10.3892/mmr.2017.6718
Pages: 1007-1013

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Abstract

Preeclampsia (PE) is one of the most common types of hypertensive disease and occurs in 3‑4% of pregnancies. There are a number of theories on the pathogenesis of PE. Abnormal differentiation of the placenta may lead to failure of trophoblast migration, shallow placenta implantation and placental ischemia/hypoxia, followed by the subsequent occurrence of PE. The Wnt/β-catenin pathway is a canonical Wnt‑signaling pathway that regulates several biological processes, including proliferation, migration, invasion and apoptosis. Abnormal activation of the Wnt/β‑catenin signaling pathway may serve an important role in the pathogenesis of various human diseases, particularly in human cancer. Recent studies have demonstrated that the dysregulation of the Wnt/β‑catenin signaling pathway may contribute to PE. The present review aims to summarize the articles on Wnt/β‑catenin signaling pathway in the trophoblast and abnormal activation in PE. Wnt/β-catenin signaling may serve a significant role in the pathogenesis of PE and may be a prospective therapeutic target for the prevention and treatment of PE.

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