Open Access

High glucose promotes hepatic fibrosis via miR‑32/MTA3‑mediated epithelial‑to‑mesenchymal transition

Corrigendum in: /10.3892/mmr.2022.12827

  • Authors:
    • Qiang Li
    • Zhange Li
    • Yuan Lin
    • Hui Che
    • Yingying Hu
    • Xujuan Kang
    • Ying Zhang
    • Lihong Wang
    • Yong Zhang
  • View Affiliations

  • Published online on: February 25, 2019     https://doi.org/10.3892/mmr.2019.9986
  • Pages: 3190-3200
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Hepatic fibrosis is characterized by the aberrant production and deposition of extracellular matrix (ECM) proteins. Growing evidence indicates that the epithelial‑mesenchymal transition serves a crucial role in the progression of liver fibrogenesis. Although a subset of microRNAs (miRNAs or miRs) has recently been identified as essential regulators of the EMT gene expression, studies of the EMT in hyperglycemic‑induced liver fibrosis are limited. In the current study, it was observed that high glucose‑treated AML12 cells occurred EMT process, and miR‑32 expression was markedly increased in the liver tissue of streptozotocin‑induced diabetic rats and in high glucose‑treated AML12 cells. Additionally, the contribution of the EMT to liver fibrosis by targeting metastasis‑associated gene 3 (MTA3) under hyperglycemic conditions was suppressed by AMO‑32. The results indicated that miR‑32 and MTA3 may be considered as novel drug targets in the prevention and treatment of liver fibrosis under hyperglycemic conditions. These finding improves the understanding of the progression of liver fibrogenesis.
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April-2019
Volume 19 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Li Q, Li Z, Lin Y, Che H, Hu Y, Kang X, Zhang Y, Wang L and Zhang Y: High glucose promotes hepatic fibrosis via miR‑32/MTA3‑mediated epithelial‑to‑mesenchymal transition Corrigendum in /10.3892/mmr.2022.12827. Mol Med Rep 19: 3190-3200, 2019.
APA
Li, Q., Li, Z., Lin, Y., Che, H., Hu, Y., Kang, X. ... Zhang, Y. (2019). High glucose promotes hepatic fibrosis via miR‑32/MTA3‑mediated epithelial‑to‑mesenchymal transition Corrigendum in /10.3892/mmr.2022.12827. Molecular Medicine Reports, 19, 3190-3200. https://doi.org/10.3892/mmr.2019.9986
MLA
Li, Q., Li, Z., Lin, Y., Che, H., Hu, Y., Kang, X., Zhang, Y., Wang, L., Zhang, Y."High glucose promotes hepatic fibrosis via miR‑32/MTA3‑mediated epithelial‑to‑mesenchymal transition Corrigendum in /10.3892/mmr.2022.12827". Molecular Medicine Reports 19.4 (2019): 3190-3200.
Chicago
Li, Q., Li, Z., Lin, Y., Che, H., Hu, Y., Kang, X., Zhang, Y., Wang, L., Zhang, Y."High glucose promotes hepatic fibrosis via miR‑32/MTA3‑mediated epithelial‑to‑mesenchymal transition Corrigendum in /10.3892/mmr.2022.12827". Molecular Medicine Reports 19, no. 4 (2019): 3190-3200. https://doi.org/10.3892/mmr.2019.9986