Open Access

Research progress on long non‑coding RNAs in non‑infectious spinal diseases (Review)

  • Authors:
    • Zhong Ma
    • Xin Liu
    • Xianxu Zhang
    • Shicheng Li
    • Jiangdong An
    • Zhiqiang Luo
  • View Affiliations

  • Published online on: July 9, 2024     https://doi.org/10.3892/mmr.2024.13288
  • Article Number: 164
  • Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Spinal diseases, including intervertebral disc degeneration (IDD), ankylosing spondylitis, spinal cord injury and other non‑infectious spinal diseases, severely affect the quality of life of patients. Current treatments for IDD and other spinal diseases can only relieve symptoms and do not completely cure the disease. Therefore, there is an urgent need to explore the causes of these diseases and develop new treatment approaches. Long non‑coding RNA (lncRNA), a form of non‑coding RNA, is abundant in diverse sources, has numerous functions, and plays an important role in the occurrence and development of spinal diseases such as IDD. However, the mechanism of action of lncRNAs has not been fully elucidated, and significant challenges remain in the use of lncRNAs as new therapeutic targets. The present article reviews the sources, classification and functions of lncRNAs, and introduces the role of lncRNAs in spinal diseases, such as IDD, and their therapeutic potential.
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September-2024
Volume 30 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Ma Z, Liu X, Zhang X, Li S, An J and Luo Z: Research progress on long non‑coding RNAs in non‑infectious spinal diseases (Review). Mol Med Rep 30: 164, 2024.
APA
Ma, Z., Liu, X., Zhang, X., Li, S., An, J., & Luo, Z. (2024). Research progress on long non‑coding RNAs in non‑infectious spinal diseases (Review). Molecular Medicine Reports, 30, 164. https://doi.org/10.3892/mmr.2024.13288
MLA
Ma, Z., Liu, X., Zhang, X., Li, S., An, J., Luo, Z."Research progress on long non‑coding RNAs in non‑infectious spinal diseases (Review)". Molecular Medicine Reports 30.3 (2024): 164.
Chicago
Ma, Z., Liu, X., Zhang, X., Li, S., An, J., Luo, Z."Research progress on long non‑coding RNAs in non‑infectious spinal diseases (Review)". Molecular Medicine Reports 30, no. 3 (2024): 164. https://doi.org/10.3892/mmr.2024.13288