Open Access

Tetraspanins in digestive‑system cancers: Expression, function and therapeutic potential (Review)

  • Authors:
    • Kexin Chen
    • Qiuhong Li
    • Yangyi Li
    • Donghui Jiang
    • Ligang Chen
    • Jun Jiang
    • Shengbiao Li
    • Chunxiang Zhang
  • View Affiliations

  • Published online on: September 6, 2024     https://doi.org/10.3892/mmr.2024.13324
  • Article Number: 200
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The tetraspanin family of membrane proteins is essential for controlling different biological processes such as cell migration, penetration, adhesion, growth, apoptosis, angiogenesis and metastasis. The present review summarized the current knowledge regarding the expression and roles of tetraspanins in different types of cancer of the digestive system, including gastric, liver, colorectal, pancreatic, esophageal and oral cancer. Depending on the type and context of cancer, tetraspanins can act as either tumor promoters or suppressors. In the present review, the importance of tetraspanins in serving as biomarkers and targets for different types of digestive system‑related cancer was emphasized. Additionally, the molecular mechanisms underlying the involvement of tetraspanins in cancer progression and metastasis were explored. Furthermore, the current challenges are addressed and future research directions for advancing investigations related to tetraspanins in the context of digestive system malignancies are proposed.
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November-2024
Volume 30 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Chen K, Li Q, Li Y, Jiang D, Chen L, Jiang J, Li S and Zhang C: Tetraspanins in digestive‑system cancers: Expression, function and therapeutic potential (Review). Mol Med Rep 30: 200, 2024.
APA
Chen, K., Li, Q., Li, Y., Jiang, D., Chen, L., Jiang, J. ... Zhang, C. (2024). Tetraspanins in digestive‑system cancers: Expression, function and therapeutic potential (Review). Molecular Medicine Reports, 30, 200. https://doi.org/10.3892/mmr.2024.13324
MLA
Chen, K., Li, Q., Li, Y., Jiang, D., Chen, L., Jiang, J., Li, S., Zhang, C."Tetraspanins in digestive‑system cancers: Expression, function and therapeutic potential (Review)". Molecular Medicine Reports 30.5 (2024): 200.
Chicago
Chen, K., Li, Q., Li, Y., Jiang, D., Chen, L., Jiang, J., Li, S., Zhang, C."Tetraspanins in digestive‑system cancers: Expression, function and therapeutic potential (Review)". Molecular Medicine Reports 30, no. 5 (2024): 200. https://doi.org/10.3892/mmr.2024.13324