Open Access

Gut‑liver axis in liver disease: From basic science to clinical treatment (Review)

  • Authors:
    • Jianpeng Wang
    • Xinyi Wang
    • Enba Zhuo
    • Bangjie Chen
    • Shixin Chan
  • View Affiliations

  • Published online on: October 23, 2024     https://doi.org/10.3892/mmr.2024.13375
  • Article Number: 10
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Incidence of a number of liver diseases has increased. Gut microbiota serves a role in the pathogenesis of hepatitis, cirrhosis and liver cancer. Gut microbiota is considered ‘a new virtual metabolic organ’. The interaction between the gut microbiota and liver is termed the gut‑liver axis. The gut‑liver axis provides a novel research direction for mechanism of liver disease development. The present review discusses the role of the gut‑liver axis and how this can be targeted by novel treatments for common liver diseases. 

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January-2025
Volume 31 Issue 1

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Copy and paste a formatted citation
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Spandidos Publications style
Wang J, Wang X, Zhuo E, Chen B and Chan S: Gut‑liver axis in liver disease: From basic science to clinical treatment (Review). Mol Med Rep 31: 10, 2025.
APA
Wang, J., Wang, X., Zhuo, E., Chen, B., & Chan, S. (2025). Gut‑liver axis in liver disease: From basic science to clinical treatment (Review). Molecular Medicine Reports, 31, 10. https://doi.org/10.3892/mmr.2024.13375
MLA
Wang, J., Wang, X., Zhuo, E., Chen, B., Chan, S."Gut‑liver axis in liver disease: From basic science to clinical treatment (Review)". Molecular Medicine Reports 31.1 (2025): 10.
Chicago
Wang, J., Wang, X., Zhuo, E., Chen, B., Chan, S."Gut‑liver axis in liver disease: From basic science to clinical treatment (Review)". Molecular Medicine Reports 31, no. 1 (2025): 10. https://doi.org/10.3892/mmr.2024.13375