Open Access

Baicalein suppresses inflammation and attenuates acute lung injury by inhibiting glycolysis via HIF‑1α signaling

  • Authors:
    • Zhongyou Liu
    • Xiaona Zheng
    • Ning Li
    • Zongyao Wang
  • View Affiliations

  • Published online on: November 5, 2024     https://doi.org/10.3892/mmr.2024.13383
  • Article Number: 18
  • Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Baicalein, a flavonoid monomer compound isolated from the dried root of the traditional Chinese herb Scutellaria baicalensis, has several pharmacological activities, such as anti‑inflammatory, anti‑angiogenic, antitumor, antimicrobial and antiviral properties. Acute lung injury (ALI) is characterized by injury of the alveolar epithelium and capillary endothelium, which results in decreased lung volume, decreased lung compliance, ventilation/perfusion mismatch, intrapulmonary edema, alveolar edema and even acute hypoxemic respiratory failure. The present study aimed to investigate the effects of baicalein on lung injury and inflammation. Bioinformatics analysis using network pharmacology predicted that the hypoxia inducible factor‑1α (HIF‑1α) and glycolysis signaling pathways were involved in the mechanism underlying the therapeutic effects of baicalein. Further in vitro and in vivo experiments, such as immunohistochemistry, immunofluorescence and PCR, verified that baicalein could inhibit HIF‑1α signaling, thus suppressing glycolysis, and improving inflammatory responses and ALI. Taken together, the results of the present study suggested that the anti‑inflammatory effects of baicalein on treating ALI were associated with its ability to suppress glycolysis via the HIF‑1α signaling pathway.

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January-2025
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Copy and paste a formatted citation
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Spandidos Publications style
Liu Z, Zheng X, Li N and Wang Z: Baicalein suppresses inflammation and attenuates acute lung injury by inhibiting glycolysis via HIF‑1α signaling. Mol Med Rep 31: 18, 2025.
APA
Liu, Z., Zheng, X., Li, N., & Wang, Z. (2025). Baicalein suppresses inflammation and attenuates acute lung injury by inhibiting glycolysis via HIF‑1α signaling. Molecular Medicine Reports, 31, 18. https://doi.org/10.3892/mmr.2024.13383
MLA
Liu, Z., Zheng, X., Li, N., Wang, Z."Baicalein suppresses inflammation and attenuates acute lung injury by inhibiting glycolysis via HIF‑1α signaling". Molecular Medicine Reports 31.1 (2025): 18.
Chicago
Liu, Z., Zheng, X., Li, N., Wang, Z."Baicalein suppresses inflammation and attenuates acute lung injury by inhibiting glycolysis via HIF‑1α signaling". Molecular Medicine Reports 31, no. 1 (2025): 18. https://doi.org/10.3892/mmr.2024.13383