Open Access

Annexin A1: The dawn of ischemic stroke (Review)

  • Authors:
    • Chen Tang
    • Rui Lan
    • Dong-Rui Ma
    • Min Zhao
    • Yong Zhang
    • Hong-Yu Li
    • Shuang Liu
    • Bo-Yang Li
    • Jie-Li Yang
    • Hui-Jie Yang
    • Zhen-Qiang Zhang
  • View Affiliations

  • Published online on: December 31, 2024     https://doi.org/10.3892/mmr.2024.13427
  • Article Number: 62
  • Copyright: © Tang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Ischemic stroke is a prevalent clinical condition that poses a significant global challenge. Developing innovative strategies to address this issue is crucial. Annexin A1 (ANXA1), a key member of the annexin superfamily, performs various functions, such as inhibiting inflammatory factor release, promoting phagocytosis, and blocking leukocyte migration. Evidence indicates that ANXA1 plays a pivotal role in the pathogenesis of ischemic stroke. The present article reviews involvement of ANXA1 in anti‑atherosclerosis, inflammatory processes, blood‑brain barrier protection, platelet aggregation and anti‑apoptotic mechanisms. The potential applications of ANXA1 in treating ischemic stroke are also explored.
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March-2025
Volume 31 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Tang C, Lan R, Ma D, Zhao M, Zhang Y, Li H, Liu S, Li B, Yang J, Yang H, Yang H, et al: Annexin A1: The dawn of ischemic stroke (Review). Mol Med Rep 31: 62, 2025.
APA
Tang, C., Lan, R., Ma, D., Zhao, M., Zhang, Y., Li, H. ... Zhang, Z. (2025). Annexin A1: The dawn of ischemic stroke (Review). Molecular Medicine Reports, 31, 62. https://doi.org/10.3892/mmr.2024.13427
MLA
Tang, C., Lan, R., Ma, D., Zhao, M., Zhang, Y., Li, H., Liu, S., Li, B., Yang, J., Yang, H., Zhang, Z."Annexin A1: The dawn of ischemic stroke (Review)". Molecular Medicine Reports 31.3 (2025): 62.
Chicago
Tang, C., Lan, R., Ma, D., Zhao, M., Zhang, Y., Li, H., Liu, S., Li, B., Yang, J., Yang, H., Zhang, Z."Annexin A1: The dawn of ischemic stroke (Review)". Molecular Medicine Reports 31, no. 3 (2025): 62. https://doi.org/10.3892/mmr.2024.13427