Open Access

Pin1 as a central node in oncogenic signaling: Mechanistic insights and clinical prospects (Review)

  • Authors:
    • Shuning Lei
    • Min Luo
    • Yuxue Wang
  • View Affiliations

  • Published online on: January 27, 2025     https://doi.org/10.3892/mmr.2025.13445
  • Article Number: 80
  • Copyright: © Lei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Peptidyl‑prolyl cis‑trans isomerase NIMA-interacting 1 (Pin1) is a specific phosphorylated serine/threonine-proline cis-trans isomerase, which is involved in the regulation of a variety of physiological and pathological processes, including cell cycle progression, proliferation and apoptosis. Pin1 plays a key role in tumorigenesis and tumor development and it promotes the proliferation and metastasis of cancer cells by regulating the cell cycle, signaling pathways and the function of tumor suppressors. Upregulated expression of Pin1 is closely associated with a poor prognosis in several types of cancers. Thus, Pin1 is may have potential as a novel potential biomarker for tumor diagnosis and prognosis, as well as a promising anticancer target. The aim of the present review was to discuss the mechanism of Pin1 in tumors and recent research progress in this field.
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March-2025
Volume 31 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Lei S, Luo M and Wang Y: Pin1 as a central node in oncogenic signaling: Mechanistic insights and clinical prospects (Review). Mol Med Rep 31: 80, 2025.
APA
Lei, S., Luo, M., & Wang, Y. (2025). Pin1 as a central node in oncogenic signaling: Mechanistic insights and clinical prospects (Review). Molecular Medicine Reports, 31, 80. https://doi.org/10.3892/mmr.2025.13445
MLA
Lei, S., Luo, M., Wang, Y."Pin1 as a central node in oncogenic signaling: Mechanistic insights and clinical prospects (Review)". Molecular Medicine Reports 31.3 (2025): 80.
Chicago
Lei, S., Luo, M., Wang, Y."Pin1 as a central node in oncogenic signaling: Mechanistic insights and clinical prospects (Review)". Molecular Medicine Reports 31, no. 3 (2025): 80. https://doi.org/10.3892/mmr.2025.13445