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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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November-December 2011 Volume 2 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Article

Elevated expression of solute carrier family 22 member 18 increases the sensitivity of U251 glioma cells to BCNU

  • Authors:
    • Sheng-Hua Chu
    • Yan-Bin Ma
    • Dong-Fu Feng
    • Hong Zhang
    • Jian-Hua Qiu
    • Zhi-An Zhu

  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 201900, P.R. China
  • Pages: 1139-1142
    |
    Published online on: August 4, 2011
       https://doi.org/10.3892/ol.2011.371
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Abstract

Previous studies showed that solute carrier family 22 member 18 (SLC22A18) is involved in tumorigenesis. The aim of this study was to examine the role of SLC22A18 in glioma cells. Glioma U251 cells were transfected with the human SLC22A18 gene. Transfection of the empty vector pcDNA3.1 was used as a negative control. Sensitivity to BCNU was measured by Annexin V staining. The expression of caspase-3 and bcl-2 was determined by immunohistochemistry. The transfection was confirmed by PCR, RT-PCR and Western blotting. Augmented apoptotic cell death was observed in the SLC22A18-transfected cells, compared to the non-transfected cells or cells with the empty vector. Caspase-3 expression increased in U251‑SLC22A18 cells, whereas the bcl-2 expression decreased. These results indicated that SLC22A18 has a pro-apoptotic function in glioma cells.
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Copy and paste a formatted citation
Spandidos Publications style
Chu S, Ma Y, Feng D, Zhang H, Qiu J and Zhu Z: Elevated expression of solute carrier family 22 member 18 increases the sensitivity of U251 glioma cells to BCNU. Oncol Lett 2: 1139-1142, 2011.
APA
Chu, S., Ma, Y., Feng, D., Zhang, H., Qiu, J., & Zhu, Z. (2011). Elevated expression of solute carrier family 22 member 18 increases the sensitivity of U251 glioma cells to BCNU. Oncology Letters, 2, 1139-1142. https://doi.org/10.3892/ol.2011.371
MLA
Chu, S., Ma, Y., Feng, D., Zhang, H., Qiu, J., Zhu, Z."Elevated expression of solute carrier family 22 member 18 increases the sensitivity of U251 glioma cells to BCNU". Oncology Letters 2.6 (2011): 1139-1142.
Chicago
Chu, S., Ma, Y., Feng, D., Zhang, H., Qiu, J., Zhu, Z."Elevated expression of solute carrier family 22 member 18 increases the sensitivity of U251 glioma cells to BCNU". Oncology Letters 2, no. 6 (2011): 1139-1142. https://doi.org/10.3892/ol.2011.371
Copy and paste a formatted citation
x
Spandidos Publications style
Chu S, Ma Y, Feng D, Zhang H, Qiu J and Zhu Z: Elevated expression of solute carrier family 22 member 18 increases the sensitivity of U251 glioma cells to BCNU. Oncol Lett 2: 1139-1142, 2011.
APA
Chu, S., Ma, Y., Feng, D., Zhang, H., Qiu, J., & Zhu, Z. (2011). Elevated expression of solute carrier family 22 member 18 increases the sensitivity of U251 glioma cells to BCNU. Oncology Letters, 2, 1139-1142. https://doi.org/10.3892/ol.2011.371
MLA
Chu, S., Ma, Y., Feng, D., Zhang, H., Qiu, J., Zhu, Z."Elevated expression of solute carrier family 22 member 18 increases the sensitivity of U251 glioma cells to BCNU". Oncology Letters 2.6 (2011): 1139-1142.
Chicago
Chu, S., Ma, Y., Feng, D., Zhang, H., Qiu, J., Zhu, Z."Elevated expression of solute carrier family 22 member 18 increases the sensitivity of U251 glioma cells to BCNU". Oncology Letters 2, no. 6 (2011): 1139-1142. https://doi.org/10.3892/ol.2011.371
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