Altered expression of Krüppel-like factor 4 and β-catenin in human gastric cancer

  • Authors:
    • N. Zhang
    • J. Zhang
    • Z.W. Wang
    • L. Zha
    • Z. Huang
  • View Affiliations

  • Published online on: February 28, 2012     https://doi.org/10.3892/ol.2012.619
  • Pages: 1017-1022
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Abstract

The effects of the interaction between KLF4 and β-catenin may be significant in human carcinogenesis and tumor development. This study aimed to determine whether the expression of KLF4 and β-catenin in gastric cancer tissues is associated with clinicopathological characteristics. Western blot analysis and immunohistochemistry were performed to detect KLF4 and β-catenin expression in tumor and corresponding non-cancerous tissues from 49 patients. The data revealed that KLF4 expression was significantly reduced in gastric cancer tissues compared with normal tissues. By contrast, the expression of the β-catenin protein was significantly increased in all tumor tissues, but was not expressed in distant normal mucosae. The altered expression of the KLF4 and β-catenin proteins was associated with advanced tumor stage and gastric cancer. In addition, the expression of the KLF4 and β-catenin proteins was inversely associated in moderately differentiated human gastric cancers. This study showed that β-catenin expression is significantly increased and KLF4 protein expression is markedly decreased in gastric cancer tissues, thus showing that the expression of KLF4 is inversely correlated with that of β-catenin in gastric cancer. The altered expression of the two proteins is associated with advanced tumor stage in gastric cancer.
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May 2012
Volume 3 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhang N, Zhang J, Wang Z, Zha L and Huang Z: Altered expression of Krüppel-like factor 4 and β-catenin in human gastric cancer. Oncol Lett 3: 1017-1022, 2012.
APA
Zhang, N., Zhang, J., Wang, Z., Zha, L., & Huang, Z. (2012). Altered expression of Krüppel-like factor 4 and β-catenin in human gastric cancer. Oncology Letters, 3, 1017-1022. https://doi.org/10.3892/ol.2012.619
MLA
Zhang, N., Zhang, J., Wang, Z., Zha, L., Huang, Z."Altered expression of Krüppel-like factor 4 and β-catenin in human gastric cancer". Oncology Letters 3.5 (2012): 1017-1022.
Chicago
Zhang, N., Zhang, J., Wang, Z., Zha, L., Huang, Z."Altered expression of Krüppel-like factor 4 and β-catenin in human gastric cancer". Oncology Letters 3, no. 5 (2012): 1017-1022. https://doi.org/10.3892/ol.2012.619