Open Access

Propyl isothiocyanate induces apoptosis in gastric cancer cells by oxidative stress via glutathione depletion

  • Authors:
    • Ling Huang
    • Chen Cai
    • Wei Dang
    • Jian‑Hua Lu
    • Gang‑Feng Hu
    • Jun Gu
  • View Affiliations

  • Published online on: September 18, 2019     https://doi.org/10.3892/ol.2019.10875
  • Pages: 5490-5498
  • Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Isothiocyanates are a group of compounds that exist in the majority of cruciferous plants. A number of isothiocyanates have been demonstrated to exhibit anticancer effects; however, antitumor properties of propyl isothiocyanate (PITC) have not been evaluated previously. In this study, the possible effects of PITC on gastric cancer (GC) cells were investigated, and the potential underlying mechanisms were explored. The results demonstrated that PITC inhibited cell viability of two GC cell lines and induced cell cycle arrest and apoptosis. Treatment with PITC promoted total glutathione depletion in GC cell lines, leading to reactive oxygen species accumulation and DNA damage, which activated the mitochondria‑dependent and p53 signaling pathways to trigger apoptosis in GC cells. The effects of PITC were reversed by N‑Acetyl‑L‑cysteine. The results of the present study revealed the potential mechanisms of PITC on apoptosis induction in GC cells, which may be mediated by mitochondria‑dependent apoptosis and DNA damage.
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November-2019
Volume 18 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Huang L, Cai C, Dang W, Lu JH, Hu GF and Gu J: Propyl isothiocyanate induces apoptosis in gastric cancer cells by oxidative stress via glutathione depletion. Oncol Lett 18: 5490-5498, 2019.
APA
Huang, L., Cai, C., Dang, W., Lu, J., Hu, G., & Gu, J. (2019). Propyl isothiocyanate induces apoptosis in gastric cancer cells by oxidative stress via glutathione depletion. Oncology Letters, 18, 5490-5498. https://doi.org/10.3892/ol.2019.10875
MLA
Huang, L., Cai, C., Dang, W., Lu, J., Hu, G., Gu, J."Propyl isothiocyanate induces apoptosis in gastric cancer cells by oxidative stress via glutathione depletion". Oncology Letters 18.5 (2019): 5490-5498.
Chicago
Huang, L., Cai, C., Dang, W., Lu, J., Hu, G., Gu, J."Propyl isothiocyanate induces apoptosis in gastric cancer cells by oxidative stress via glutathione depletion". Oncology Letters 18, no. 5 (2019): 5490-5498. https://doi.org/10.3892/ol.2019.10875