Decoding the diagnostic dilemma: Peripheral T‑cell lymphoma presenting as acute pancreatitis: A case report

Vikash,Fnu; Vikash,Sindhu; Mehta,Ansh; Nagraj,Sanjana; Patel,Sunny; Ho,Sammy; Kotler,Donald

doi:10.3892/ol.2023.14206

Decoding the diagnostic dilemma: Peripheral T‑cell lymphoma presenting as acute pancreatitis: A case report

Authors:
- Fnu Vikash
- Sindhu Vikash
- Ansh Mehta
- Sanjana Nagraj
- Sunny Patel
- Sammy Ho
- Donald Kotler
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Affiliations: Department of Internal Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, New York, NY 10461, USA, Department of Hematology and Oncology, Jacobi Medical Center, Albert Einstein College of Medicine, New York, NY 10461, USA, Department of Gastroenterology, Jacobi Medical Center, Albert Einstein College of Medicine, New York, NY 10461, USA, Department of Gastroenterology, Montefiore Medical Center, Albert Einstein College of Medicine, New York, NY 10461, USA
Published online on: December 22, 2023 https://doi.org/10.3892/ol.2023.14206
Article Number: 73
Copyright: © Vikash et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Peripheral T cell lymphoma (PTCL) is a rare form of non‑Hodgkin lymphoma characterized by the origin of mature T‑cells. PTCL demonstrates atypical clinical features and involves both nodal and extra‑nodal sites. The diagnosis and treatment of PTCL can prove to be challenging, as it is often detected at advanced stages and is resistant to conventional chemotherapy treatments. The present report describes a 55‑year‑old male patient who presented with acute pancreatitis, and imaging suggested a soft tissue mass in the pancreatic head indicating pancreatic adenocarcinoma. Further investigation through ultrasound‑guided biopsy led to the diagnosis of pancreatic PTCL not otherwise specified.

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1	Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, Advani R, Ghielmini M, Salles GA, Zelenetz AD and Jaffe ES: The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 127:2375–2390. 2016. View Article : Google Scholar : PubMed/NCBI
2	Weisenburger DD, Savage KJ, Harris NL, Gascoyne RD, Jaffe ES, MacLennan KA, Rüdiger T, Pileri S, Nakamura S, Nathwani B, et al: Peripheral T-cell lymphoma, not otherwise specified: A report of 340 cases from the international peripheral T-cell lymphoma project. Blood. 117:3402–3408. 2011. View Article : Google Scholar : PubMed/NCBI
3	Lee J, Park KS, Kang MH, Kim Y, Son SM, Choi H, Choi JW and Ryu DH: Primary hepatic peripheral T-cell lymphoma mimicking hepatocellular carcinoma: A case report. Ann Surg Treat Res. 93:110–114. 2017. View Article : Google Scholar : PubMed/NCBI
4	Petrova M, Gomes MM, Carda JPN and Pereira de Moura J: Hepatosplenic T-cell lymphoma in a young immunocompetent man. BMJ Case Rep. 2016:bcr20162144142016. View Article : Google Scholar : PubMed/NCBI
5	Jiang M, Bennani NN and Feldman AL: Lymphoma classification update: T-cell lymphomas, Hodgkin lymphomas, and histiocytic/dendritic cell neoplasms. Expert Rev Hematol. 10:239–249. 2017. View Article : Google Scholar : PubMed/NCBI
6	Horwitz S, O'Connor OA, Pro B, Trümper L, Iyer S, Advani R, Bartlett NL, Christensen JH, Morschhauser F, Domingo-Domenech E, et al: The ECHELON-2 Trial: 5-Year results of a randomized, phase III study of brentuximab vedotin with chemotherapy for CD30-positive peripheral T-cell lymphoma. Ann Oncol. 33:288–298. 2022. View Article : Google Scholar : PubMed/NCBI
7	Avlonitis VS and Linos D: Primary hepatic lymphoma: A review. Eur J Surg. 165:725–729. 1999. View Article : Google Scholar : PubMed/NCBI
8	Thomas PC, Nash GF and Aldridge MC: Pancreatic acinar cell carcinoma presenting as acute pancreatitis. HPB (Oxford). 5:111–113. 2003. View Article : Google Scholar : PubMed/NCBI
9	Safadi R, Or R, Bar Ziv J and Polliack A: Lymphoma-associated pancreatitis as a presenting manifestation of immunoblastic lymphoma. Leuk Lymphoma. 12:317–319. 1994. View Article : Google Scholar : PubMed/NCBI
10	To CA, Quigley MM, Saven A and Nicholson L: Masquerade without a mass: An unusual cause of severe acute pancreatitis. J Gastrointest Oncol. 4:114–117. 2013.PubMed/NCBI
11	Gazelle GS, Lee MJ, Hahn PF, Goldberg MA, Rafaat N and Mueller PR: US, CT, and MRI of primary and secondary liver lymphoma. J Comput Assist Tomogr. 18:412–415. 1994. View Article : Google Scholar : PubMed/NCBI
12	Saif MW: Primary pancreatic lymphomas. JOP. 7:262–273. 2006.PubMed/NCBI
13	Merkle EM, Bender GN and Brambs HJ: Imaging findings in pancreatic lymphoma: Differential aspects. AJR Am J Roentgenol. 174:671–675. 2000. View Article : Google Scholar : PubMed/NCBI
14	Foss FM, Zinzani PL, Vose JM, Gascoyne RD, Rosen ST and Tobinai K: Peripheral T-cell lymphoma. Blood. 117:6756–6767. 2011. View Article : Google Scholar : PubMed/NCBI
15	Jeon YK, Kim JH, Sung JY, Han JH and Ko YH; Hematopathology Study Group of the Korean Society of Pathologists, : Epstein-Barr virus-positive nodal T/NK-cell lymphoma: An analysis of 15 cases with distinct clinicopathological features. Hum Pathol. 46:981–990. 2015. View Article : Google Scholar : PubMed/NCBI
16	Liu Z, Medeiros LJ and Young KH: Peripheral T-cell lymphoma with unusual clinical presentation of rhabdomyolysis. Hematol Oncol. 35:125–129. 2017. View Article : Google Scholar : PubMed/NCBI
17	Kawanishi K, Ohyama Y, Kanai Y, Hirase T, Tanaka H, Miyatake J, Tatsumi Y, Ashida T, Nakamine H and Matsumura I: Sub-acute demyelinating polyradiculoneuropathy as an initial symptom of peripheral T cell lymphoma, not otherwise specified (PTCL-NOS). Intern Med. 51:2015–2020. 2012. View Article : Google Scholar : PubMed/NCBI