Open Access

Progress in cancer research on the regulator of phagocytosis CD47, which determines the fate of tumor cells (Review)

  • Authors:
    • Fan Wu
    • Hongyuan Pang
    • Fan Li
    • Mengqing Hua
    • Chuanwang Song
    • Jie Tang
  • View Affiliations

  • Published online on: April 9, 2024     https://doi.org/10.3892/ol.2024.14389
  • Article Number: 256
  • Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cluster of differentiation 47 (CD47) is a transmembrane protein that is widely and moderately expressed on the surface of various cells and can have an essential role in mediating cell proliferation, migration, phagocytosis, apoptosis, immune homeostasis and other related responses by binding to its ligands, integrins, thrombospondin‑1 and signal regulatory protein α. The poor prognosis of cancer patients is closely associated with high expression of CD47 in glioblastoma, ovarian cancer, breast cancer, bladder cancer, colon cancer and hepatocellular carcinoma. Upregulation of CD47 expression facilitates the growth of numerous types of tumor cells, while downregulation of its expression promotes phagocytosis of tumor cells by macrophages, thereby limiting tumor growth. In addition, blocking CD47 activates the cyclic GMP‑AMP (cGAMP) synthase/cGAMP/interferon gene stimulating factor signaling pathway and initiates an adaptive immune response that kills tumor cells. The present review describes the structure, function and interactions of CD47 with its ligands, as well as its regulation of phagocytosis and tumor cell fate. It summarizes the therapeutics, mechanisms of action, research advances and challenges of targeting CD47. In addition, this paper provides an overview of the latest therapeutic options for targeting CD47, such as chimeric antigen receptor (CAR) T‑cells, CAR macrophages and nanotechnology‑based delivery systems, which are essential for future clinical research on targeting CD47.
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June-2024
Volume 27 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wu F, Pang H, Li F, Hua M, Song C and Tang J: Progress in cancer research on the regulator of phagocytosis CD47, which determines the fate of tumor cells (Review). Oncol Lett 27: 256, 2024
APA
Wu, F., Pang, H., Li, F., Hua, M., Song, C., & Tang, J. (2024). Progress in cancer research on the regulator of phagocytosis CD47, which determines the fate of tumor cells (Review). Oncology Letters, 27, 256. https://doi.org/10.3892/ol.2024.14389
MLA
Wu, F., Pang, H., Li, F., Hua, M., Song, C., Tang, J."Progress in cancer research on the regulator of phagocytosis CD47, which determines the fate of tumor cells (Review)". Oncology Letters 27.6 (2024): 256.
Chicago
Wu, F., Pang, H., Li, F., Hua, M., Song, C., Tang, J."Progress in cancer research on the regulator of phagocytosis CD47, which determines the fate of tumor cells (Review)". Oncology Letters 27, no. 6 (2024): 256. https://doi.org/10.3892/ol.2024.14389