Value of exhaled hydrogen sulfide in early diagnosis of esophagogastric junction adenocarcinoma

Liu,Fang; Wei,Lai; Zheng,Bosheng; Su,Xin; Ju,Jianmei; Liu,Guangjie; Liu,Qingyi

doi:10.3892/ol.2024.14454

Value of exhaled hydrogen sulfide in early diagnosis of esophagogastric junction adenocarcinoma

Authors:
- Fang Liu
- Lai Wei
- Bosheng Zheng
- Xin Su
- Jianmei Ju
- Guangjie Liu
- Qingyi Liu
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Affiliations: Department of Hospital Quality and Control, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050001, P.R. China, Department of Thoracic Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050001, P.R. China
Published online on: May 14, 2024 https://doi.org/10.3892/ol.2024.14454
Article Number: 321
Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Esophagogastric junction adenocarcinoma (EJA) has increased in recent years, and it exhibits a poor prognosis and a short survival period for patients. Hydrogen sulfide (H₂S) plays an important role in the pathogenesis of cancer and has been studied as a diagnostic factor in some tumor diseases. However, few studies have explored the diagnostic value of H₂S for EJA. In the present study, a total of 56 patients with early‑stage EJA were enrolled while 57 healthy individuals were selected as the healthy control group. Clinical features were recorded, and exhaled H₂S and blood samples were collected from both groups. Exhaled H₂S and serum interleukin‑8 (IL‑8) expression levels were detected in both groups. The correlation between exhaled H₂S and serum IL‑8 levels was analyzed using Pearson's correlation method. Receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of exhaled H₂S combined with IL‑8 detection in EJA. The results showed that patients with EJA exhaled more H₂S than healthy individuals. In addition, exhaled H₂S was positively correlated with increased IL‑8 expression. The ROC curve revealed that the exhaled H₂S test had an acceptable diagnostic effect and could be used to diagnose EJA. The increase in H₂S exhaled by patients with EJA indicated that H₂S may be related to the occurrence and development of EJA; however, the in vivo mechanism needs to be further explored. Collectively, it was determined in the present study that exhaled H₂S was significantly higher in patients with early‑stage EJA than in healthy controls and combined diagnosis with patient serum IL‑8 could improve diagnostic accuracy, which has potential diagnostic value for early diagnosis and screening of EJA.

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