Open Access

Lenvatinib in combination with transarterial chemoembolization vs. sorafenib in combination with transarterial chemoembolization for unresectable hepatocellular carcinoma: A network meta‑analysis

  • Authors:
    • Yong Li
    • Xingyu Liu
    • Junning Liu
    • Linfeng Yang
    • Song Wei
    • Jijiang Li
    • Huixin Gan
    • Ting Ma
    • Pengsheng Yi
  • View Affiliations

  • Published online on: June 3, 2024     https://doi.org/10.3892/ol.2024.14480
  • Article Number: 347
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The use of tyrosine kinase inhibitors combined with transarterial chemoembolization (TACE) is considered the standard therapy for patients with unresectable hepatocellular carcinoma (uHCC). However, information regarding the efficacy of lenvatinib or sorafenib in combination with TACE for patients with uHCC is limited. The present study involved a systematic search for randomized controlled trials on the PubMed, Embase, Web of Science and the Cochrane Library online databases to compare the use of TACE combined with either lenvatinib or sorafenib, and monotherapy using either lenvatinib or sorafenib for patients with uHCC. The network meta‑analysis of the present study included eight randomized controlled trials involving 2,929 patients. The random‑effects model was used, and hazard ratios and risk ratios with 95% CIs were calculated. Lenvatinib in combination with TACE provided the maximal overall survival (97.92%), progression‑free survival (87.8%), objective response (96.68%) and disease control (96.27%) rates. The results of the present study indicated that, in the treatment of patients with uHCC, lenvatinib in combination with TACE showed a significantly improved efficacy when compared with sorafenib and TACE. Therefore, in the future, combination therapy of lenvatinib with TACE could be potentially prioritized over sorafenib with TACE for the treatment of patients with uHCC.
View Figures
View References

Related Articles

Journal Cover

August-2024
Volume 28 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Liu X, Liu J, Yang L, Wei S, Li J, Gan H, Ma T and Yi P: Lenvatinib in combination with transarterial chemoembolization vs. sorafenib in combination with transarterial chemoembolization for unresectable hepatocellular carcinoma: A network meta‑analysis. Oncol Lett 28: 347, 2024
APA
Li, Y., Liu, X., Liu, J., Yang, L., Wei, S., Li, J. ... Yi, P. (2024). Lenvatinib in combination with transarterial chemoembolization vs. sorafenib in combination with transarterial chemoembolization for unresectable hepatocellular carcinoma: A network meta‑analysis. Oncology Letters, 28, 347. https://doi.org/10.3892/ol.2024.14480
MLA
Li, Y., Liu, X., Liu, J., Yang, L., Wei, S., Li, J., Gan, H., Ma, T., Yi, P."Lenvatinib in combination with transarterial chemoembolization vs. sorafenib in combination with transarterial chemoembolization for unresectable hepatocellular carcinoma: A network meta‑analysis". Oncology Letters 28.2 (2024): 347.
Chicago
Li, Y., Liu, X., Liu, J., Yang, L., Wei, S., Li, J., Gan, H., Ma, T., Yi, P."Lenvatinib in combination with transarterial chemoembolization vs. sorafenib in combination with transarterial chemoembolization for unresectable hepatocellular carcinoma: A network meta‑analysis". Oncology Letters 28, no. 2 (2024): 347. https://doi.org/10.3892/ol.2024.14480