Open Access

Comprehensive pan‑cancer analysis of MTDH for human tumor prognosis and as an immunological biomarker including breast and kidney cancer

  • Authors:
    • Lixian Yang
    • Mingqiang Han
    • Xiaoling Zhao
    • Lei Zheng
    • Fanting Kong
    • Shiyu Zhang
    • Lining Jia
    • Xiaowei Li
    • Meng Wang
  • View Affiliations

  • Published online on: June 3, 2024     https://doi.org/10.3892/ol.2024.14482
  • Article Number: 349
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Metadherin (MTDH), initially discovered in primary astrocytes of the human fetus through rapid subtraction hybridization and labeled as astrocyte elevated gene‑1, represents a widely recognized oncogene present in multiple types of cancers. However, the role of MTDH in different types of cancer remains unclear. To address this, a comprehensive analysis of MTDH across various types of cancers was conducted by utilizing multiple databases such as The Cancer Genome Atlas. The present analysis discovered that MTDH exhibits differential expression in different types of cancer and is associated with important factors including tumor mutational burden and microsatellite instability. These findings highlighted the significance of MTDH in the tumor microenvironment and its involvement in the development of immune cells in specific cancers. Furthermore, the results of the present study indicated that the expression of MTDH is strongly correlated with clinical prognosis, mutations and immune cell infiltration. MTDH could serve as a potential indicator of patient prognosis and potentially play a role in modulating the immune system. Given its potential as a novel immunological checkpoint, MTDH may be a viable target for tumor immunotherapy.
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August-2024
Volume 28 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Yang L, Han M, Zhao X, Zheng L, Kong F, Zhang S, Jia L, Li X and Wang M: Comprehensive pan‑cancer analysis of MTDH for human tumor prognosis and as an immunological biomarker including breast and kidney cancer. Oncol Lett 28: 349, 2024
APA
Yang, L., Han, M., Zhao, X., Zheng, L., Kong, F., Zhang, S. ... Wang, M. (2024). Comprehensive pan‑cancer analysis of MTDH for human tumor prognosis and as an immunological biomarker including breast and kidney cancer. Oncology Letters, 28, 349. https://doi.org/10.3892/ol.2024.14482
MLA
Yang, L., Han, M., Zhao, X., Zheng, L., Kong, F., Zhang, S., Jia, L., Li, X., Wang, M."Comprehensive pan‑cancer analysis of MTDH for human tumor prognosis and as an immunological biomarker including breast and kidney cancer". Oncology Letters 28.2 (2024): 349.
Chicago
Yang, L., Han, M., Zhao, X., Zheng, L., Kong, F., Zhang, S., Jia, L., Li, X., Wang, M."Comprehensive pan‑cancer analysis of MTDH for human tumor prognosis and as an immunological biomarker including breast and kidney cancer". Oncology Letters 28, no. 2 (2024): 349. https://doi.org/10.3892/ol.2024.14482